Immature NK Cells, Capable of Producing IL-22, Are Present in Human Uterine Mucosa

Male, Victoria; Hughes, Tiffany; McClory, Susan; Colucci, Francesco; Caligiuri, Michael A.; Moffett, Ashley

doi:10.4049/jimmunol.1001637

Cited by 163 publications

(189 citation statements)

References 48 publications

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“…Recruitment of CD56 C cells to the decidua has been suggested, either through increased expression of the chemokine receptors CXCR4 and CCR5 both by decidual cells and invading extravillous trophoblast cells (Hanna et al 2003). There is other evidence that uNK cells develop in situ within endometrium, either from haematopoietic stem cells (Lynch et al 2007, Vacca et al 2011 or from immature NK cell precursors (Male et al 2010). In addition, uNK cells actively proliferate in secretory-phase endometrium, with up to 40% of CD56 cells in mid-and late-secretory-phase endometrium co-expressing the cell proliferation marker Ki67 (Bulmer, unpublished observations (Pace et al 1989)).…”

Section: Decidual/uterine Nk Cellsmentioning

confidence: 99%

Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

153

104

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Section: Decidual/uterine Nk Cellsmentioning

confidence: 99%

Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

153

104

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“…Research in reproductive tissues is not as definitive, but a few studies have identified uNK cells that are capable of expressing IL-22 [15]. Although publications have shown a link between uNK cells and IL-22 expression, none have shown that IL-22 is predominantly expressed by uNK cells in the decidua of normal pregnancies, as well as in tissues of patients with unexplained RPL.…”

Section: Introductionmentioning

confidence: 99%

Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss

Perfetto

Fan

Dahl

et al. 2015

J Assist Reprod Genet

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Purpose Researchers have hypothesized that an imbalance of immune cells in the uterine decidua and a dysfunction in cytokines they produce may contribute to recurrent pregnancy loss (RPL). The objective of this study was to determine if IL-22, IL-23 and IL-17 are expressed abnormally in the decidua of patients with RPL compared to those women with a normal pregnancy. We also sought to confirm that uterine natural killer (uNK) cells are lower in the decidua of patients with RPL, as well as identify IL-22 expression by uNK cells. Methods After meeting strict inclusion criteria, maternal decidua of nine patients with unexplained RPL and a confirmed euploid fetal loss, and 11 gestational age-matched patients undergoing elective pregnancy termination were included in our analysis. Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to quantify RNA expression, Western blot was performed to quantify protein expression and immunohistochemistry (IHC) was performed to identify IL-22 and uNK cells. Results We found that women with unexplained RPL and a euploid fetal loss had significantly less gene and protein expression of IL-22 in the decidua. Additionally, we found that IL-22 is primarily expressed by uNK cells in the decidua. Conclusions In conclusion, our results suggest that lower levels of IL-22 in the uterine decidua in patients with unexplained RPL may contribute to a disruption of decidual homeostasis and ultimately lead to early pregnancy loss.

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“…Indeed NK-committed precursors were found in gut, endometrium and placenta (Chinen at al., 2007;Male et al, 2010;Vacca et al, 2011). In all these districts there is a high concentration of CD56 bright NK cells characterized by immune-regulatory activity.…”

Section: Other Sites Of In Vivo Nk Cell Developmentmentioning

confidence: 99%