Immature platelet fraction as marker for platelet recovery after stem cell transplantation in children

Hennel, Eva Kathrin; Kentouche, Karim; Beck, James F.; Kiehntopf, Michael; Boeer, Klas

doi:10.1016/j.clinbiochem.2012.03.022

Cited by 12 publications

(7 citation statements)

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“…In addition, these studies also reported high interindividual variations of studied parameters such as range 7–45 days of IRF >10% after HSCT , range 4–33 days/8–30 days of IRF/IPF recovery after HSCT , and interquartile range 14.9–22.8 days/7.1–11.9 days of IRF >12%/IPF >6% after allogeneic HSCT , which is consistent with our present study. A recent study also reported that although high IPF (%) is followed by platelet recovery in general, wide interindividual variations exist (range of period between the time point of IPF peak and platelet recovery, 1–13 days) and no recovery was also recorded in some patients, suggesting that IPF recovery is not a reliable marker for platelet recovery after HSCT . These results are consistent with our present study and underscore the lack of clinical usefulness of studied parameters in terms of wide interindividual variations, which is one of the main results of our present study.…”

Section: Discussionsupporting

confidence: 89%

“…In hematopoietic stem cell transplantation (HSCT)‐performed patients, pancytopenia caused by chemotherapy increases mortality and the need for transfusion, which can increase the risk of transfusion‐related complications such as infection and hemolytic transfusion reaction. Therefore, it would be useful to identify parameters that predict the recovery of hematopoietic cells after HSCT in transplanted patients . The automated blood cell analyzer Sysmex XE‐2100 (Sysmex, Kobe, Japan) can quantitate hematopoietic stem and progenitor cells (HPC) using the immature myeloid information channel, and its suitability was validated .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of parameters obtained from the Sysmex XN‐2000 for predicting the recovery of the absolute neutrophil count and platelets after hematopoietic stem cell transplantation

Park

Kim

et al. 2016

Int J Lab Hematology

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Evaluation of parameters obtained from the Sysmex XN‐2000 for predicting the recovery of the absolute neutrophil count and platelets after hematopoietic stem cell transplantation

Park

Kim

et al. 2016

Int J Lab Hematology

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“…They are important in various clinical situations, such as thrombocytopenia, anemia, bone marrow regeneration following the transplantation of hematopoietic stem cells and after chemotherapy 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13…”

Section: Introductionmentioning

confidence: 99%

Determination of reference ranges for immature platelet and reticulocyte fractions and reticulocyte hemoglobin equivalent

Morkis

Farias

Scotti

2016

Revista Brasileira de Hematologia e Hemoterapia

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IntroductionThe immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content. They are considered early indicators of bone marrow recovery.ObjectiveThe aim of this study was to determine the reference ranges for the immature platelet and reticulocyte fractions of hematologically normal individuals in a university hospital.MethodsVenous blood samples collected in ethylenediaminetetraacetic acid K3 were analyzed using a Sysmex XE-5000™ analyzer. Individuals with platelet and reticulocyte counts within the reference ranges, and a blood count within the laboratory's screening criteria were included. Individuals with clinical conditions that could affect hematological results were excluded. The immature platelet fraction, high, medium and low fluorescence reticulocyte fractions and reticulocyte hemoglobin equivalent were evaluated. The reference ranges were determined according to the recommendations of the International Federation of Clinical Chemistry.ResultsOne hundred and thirty-two outpatients were evaluated. The mean age was 44 years (range: 13–80 years), 72 (54.5%) were women treated in a university hospital. The mean platelet count was 250.8 × 109/L and the mean reticulocyte count was 0.052 × 109/L. The following reference ranges were obtained: immature reticulocyte fraction 1.6–12.1%, the high, medium and low fluorescence reticulocyte fractions were 0.0–1.7%, 1.6–11.0% and 87.9–98.4%, respectively, the reticulocyte hemoglobin equivalent was 30.0–37.6% and immature platelet fraction was 0.8–5.6%. There was a statistically significant difference (p-value = 0.006) between genders in respect to the immature platelet fraction with 0.8–4.7% for females and 0.7–6.1% for males. The immature reticulocyte fraction was directly correlated with the reticulocyte count.ConclusionDetermining the reference range is critical to the introduction of a new parameter. The reference ranges obtained herein corroborate those reported in previous publications and will contribute to the clinical and laboratory application of the indices.

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“…These fractions are calculated during automated reticulocyte counting by blood analyzers and thus constitute a rapid, simple test that carries no additional cost as compared to a standard reticulocyte count. They have shown good results in the assessment of marrow recovery, thrombocytopenias, and erythropoiesis among other phenomena [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Assessment of immature platelet fraction and immature reticulocyte fraction as predictors of engraftment after hematopoietic stem cell transplantation

Morkis

Farias

Rigoni

et al. 2014

Int J Lab Hematology

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Immature platelet fraction as marker for platelet recovery after stem cell transplantation in children

Cited by 12 publications

References 12 publications

Evaluation of parameters obtained from the Sysmex XN‐2000 for predicting the recovery of the absolute neutrophil count and platelets after hematopoietic stem cell transplantation

Evaluation of parameters obtained from the Sysmex XN‐2000 for predicting the recovery of the absolute neutrophil count and platelets after hematopoietic stem cell transplantation

Determination of reference ranges for immature platelet and reticulocyte fractions and reticulocyte hemoglobin equivalent

Assessment of immature platelet fraction and immature reticulocyte fraction as predictors of engraftment after hematopoietic stem cell transplantation

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