Immature teratoma of the ovary—An unusual case

Jumean, Hani G.; Komorowski, Richard; Mahvi, David M.; Anderson, Tom

doi:10.1016/0090-8258(92)90206-x

Cited by 17 publications

(9 citation statements)

References 13 publications

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“…4 The transformation could be into sarcoma, adenocarcinoma, or primitive neuroectodermal tumor. 11,24 This transformation might be due to intrinsic biological potential. Surgical resection of GTS is necessary to prevent these two above-mentioned complications.…”

Section: Discussionmentioning

confidence: 98%

Growing teratoma syndrome of ovary

et al. 2008

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Growing teratoma syndrome is an increase of tumor size containing only a mature teratoma component, during or after chemotherapy for germ cell tumors. Mature teratomatous elements are chemoresistant and have to be resected surgically. We describe three patients with malignant immature teratoma treated with chemotherapy and surgical resection. All three had an increase in the size of the mass after chemotherapy, surgery was possible, and histology revealed mature teratoma. One of the patients showed fluorodeoxy glucose positron emission tomography (FDG-PET) positivity for growing teratoma syndrome, but the histology revealed only mature teratoma. All three patients are alive, at 55, 72, and 103 months' follow up after the initial diagnosis. Data collected from the literature are reviewed. Early recognition of this syndrome is essential as it offers hope for curative resection and avoids the use of ineffective chemotherapy.

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Section: Discussionmentioning

confidence: 98%

Growing teratoma syndrome of ovary

et al. 2008

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“…Malignant transformation could be to a sarcoma, adenocarcinoma, or a primitive neuroectodermal tumor [8, 9] and carcinoid [10]. …”

Section: Discussionmentioning

confidence: 99%

Growing Teratoma Syndrome of the Ovary Showing Three Patterns of Metastasis: A Case Report

Shibata

Kajiyama

Kikkawa³

2013

Case Rep Oncol

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Growing teratoma syndrome (GTS) is defined as metastatic masses during or after chemotherapy for germ cell tumors, which contain only mature teratoma components. The peritoneum of the pelvis and abdomen and the retroperitoneum are the most frequent sites of metastasis. We report a case of GTS of the ovary showing three patterns of metastasis: dissemination, lymphogenous metastasis, and hematogenous metastasis. The patient initially presented 5 years ago with a mixed germ cell tumor of the left ovary and positive cytology of ascites. After surgery and chemotherapy, mature teratomas recurred as pelvic peritoneal dissemination, a para-aortic lymph node mass, and a lung mass. Our case highlights the importance of long-term follow-up and a whole-body search. We think that our case is suggestive regarding the mechanism of critical GTS.

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“…Elles mettent en évidence une large tumeur irrégulière d'aspect mixte, la partie solide étant constituée de nombreuses calcifications aux contours grossiers associées à du tissu graisseux disséminé [13,15]. Des hémorragies intratumorales sont souvent pré-sentes [15]. Ces examens ne permettent cependant pas de préjuger du grade histologique [16].…”

Section: Circonstances De Découverteunclassified

“…L'évolution est souvent moins rapide, mais seule l'examen anatomopathologique permettra de distinguer ces deux types de tumeurs [15].…”

Section: Circonstances De Découverteunclassified