Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma

Strand, V.; Salomonsson, P.; Lundahl, Joachim; Bylin, G

doi:10.1183/09031936.96.09040733

Cited by 37 publications

(28 citation statements)

References 30 publications

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“…Animal studies have provided evidence that the particulate fraction of DE is able to cause an increase in airway responsiveness [28], but to the best of the authors9 knowledge, there are no previous experimental data concerning particulate pollution and hyperresponsiveness in humans. Regarding the gaseous phase of DE, some studies have reported an immediate increase in airway responsiveness following exposure to NO 2 [29,30], whereas other studies have not [31]. Most studies have been designed to explore the immediate and early effects of NO 2 and it is not clear from the literature whether NO 2 is able to induce a sustained increase in airway responsiveness.…”

Section: Discussionmentioning

confidence: 97%

Diesel exhaust enhances airway responsiveness in asthmatic subjects

Nordenhäll¹,

Pourazar²,

Ledin³

et al. 2001

Eur Respir J

169

102

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Particulate matter (PM) pollution has been associated with negative health effects, including exacerbations of asthma following exposure to PM peaks. The aim of the present study was to investigate the effects of short-term exposure to diesel exhaust (DE) in asthmatics, by specifically addressing the effects on airway hyperresponsiveness, lung function and airway inflammation.Fourteen nonsmoking, atopic asthmatics with stable disease, on continuous treatment with inhaled corticosteroids, were included. All were hyperresponsive to methacholine. Each subject was exposed to DE (particles with a 50% cut-off aerodynamic diameter of 10 mm (PM10) 300 mg?m -3 ) and air during 1 h on two separate occasions. Lung function was measured before and immediately after the exposures. Sputum induction was performed 6 h, and methacholine inhalation test 24 h, after each exposure.Exposure to DE was associated with a significant increase in the degree of hyperresponsiveness, as compared to after air, of 0.97 doubling concentrations at 24 h after exposure (pv0.001). DE also induced a significant increase in airway resistance (p~0.004) and in sputum levels of interleukin (IL)-6 (p~0.048). No changes were detected in sputum levels of methyl-histamine, eosinophil cationic protein, myeloperoxidase and IL-8.This study indicated that short-term exposure to diesel exhaust, equal to high ambient levels of particulate matter, is associated with adverse effects in asthmatic airways, even in the presence of inhaled corticosteroid therapy. The increase in airway responsiveness may provide an important link to epidemiological findings of exacerbations of asthma following exposure to particulate matter. Eur Respir J 2001; 17: 909-915.

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Section: Discussionmentioning

confidence: 97%

Diesel exhaust enhances airway responsiveness in asthmatic subjects

Nordenhäll¹,

Pourazar²,

Ledin³

et al. 2001

Eur Respir J

169

102

View full text Add to dashboard Cite

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“…In healthy individuals, small increases in nonspecific airway hyperresponsiveness have been reported following short-term (1-3 hour) exposure to NO 2 in the range 1.5-2.0 ppm (Mohsenin, 1987;Frampton et al, 1989). In asthmatics, the data on nonspecific hyperresponsiveness to NO 2 suggests a sensitizing effect between 0.2 ppm and 0.6 ppm, though the responses, where significant, were small and unlikely to be of clinical significance (Bylin et al, 1985;Mohsenin, 1987;Strand et al, 1996). A limited number of studies have evaluated airway hyperresponsiveness in asthmatics at multiple NO 2 concentrations, and the results of these studies do not support a clear concentration-response relationship between 0.1 ppm and 0.5ppm (Bylin et al, 1988;Roger et al, 1990;Tunnicliffe, Burge & Ayres, 1994).…”

Section: Chamber Studiesmentioning

confidence: 92%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…The lagged-day effects, usually up to 5 days, notwithstanding the variation among the cities, indicate that the exacerbation of asthma develops over several days as the inflammation progresses in the airways of susceptible individuals. There is also laboratory-based evidence that the increase in bronchial responsiveness of asthmatics after exposure to NO 2 may be delayed, suggesting that there is a period when other triggers can provoke attacks of asthma [19]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Traffic Air Pollution and Hornbeam Pollen on Adult Asthma Hospitalizations in Zagreb

Krmpotić

Lužar-Stiffler

Rakušić

et al. 2011

Int Arch Allergy Immunol

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Background: Environmental factors play an important role in asthma morbidity, although the contribution of individual pollutants or pollens in exacerbating asthma is not completely elucidated. Despite the evidence of importance of the hornbeam pollen in inducing allergic sensitization, its role in provoking asthma exacerbation has not been evaluated. The aim of the present study was to investigate effects of traffic pollutants on adult asthma hospitalization adjusting for pollens including hornbeam. Methods: During a 3-year period, health and environmental data were collected and analyzed. Daily asthma hospitalizations were regressed on pollutants and potential confounding variables using an autoregressive Poisson model. Results: The risk of asthma hospitalization was associated significantly with the 95th to 99th percentile increase in levels of nitrogen dioxide (RR = 1.22; 95% CI: 1.05–1.40), carbon monoxide (RR = 1.25; 95% CI: 1.01–1.55) and hornbeam pollen (RR = 1.21; 95% CI: 1.11–1.30). The effect of nitrogen dioxide was delayed by 5 days. No statistically significant increase in the risk of asthma hospitalization was found for PM₁₀ particles. A comparison among the standardized regression coefficients and their respective p values indicates that the most important risk factor for asthma hospitalization is associated with hornbeam pollen levels. No statistically significant interactions between pollutants and pollens were detected. Conclusions: The current results suggest that traffic-related air pollution is associated with increased risk of adult asthma hospitalization. Nonetheless, the most significant risk for asthma hospitalization is associated with hornbeam pollen levels in the city of Zagreb.

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Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma

Cited by 37 publications

References 30 publications

Diesel exhaust enhances airway responsiveness in asthmatic subjects

Diesel exhaust enhances airway responsiveness in asthmatic subjects

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Effects of Traffic Air Pollution and Hornbeam Pollen on Adult Asthma Hospitalizations in Zagreb

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