Immediate and late effects of coronary angiography on soluble endothelial cell markers and P-selectin in patients with and without coronary artery disease

Warzok, F.; Steiner, Michael; Blann, AD; Weber, F. Parkes; Urbaszek, W; Schuff‐Werner, P.

doi:10.1097/00001721-199909000-00009

Cited by 10 publications

(9 citation statements)

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“…Although there is some variation in findings, most investigators have demonstrated increased circulating adhesion molecule levels immediately following coronary angiography and angioplasty procedures ( Table 2). [81][82][83][84] Both sP-selectin and sE-selectin levels have been demonstrated to increase in most studies. 81,83,85 However, sP-selectin levels fell immediately following coronary angioplasty, in contrast to an increase with thrombolytic therapy, for acute myocardial infarction in one study, 82 but others have found a steady increase in levels, peaking after 4 h, and have not described any difference between angioplasty and thrombolytic therapy.…”

Section: Coronary Angiography and Angioplastymentioning

confidence: 99%

Cellular adhesion molecules and cardiovascular disease. Part II. Their association with conventional and emerging risk factors, acute coronary events and cardiovascular risk prediction

Hope

Meredith

2003

Internal Medicine Journal

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The role of cellular adhesion molecules in the patho-genesis of atherosclerosis has now been clearly demonstrated. Plasma levels of adhesion molecules, which have been shed from the cell surface, have also been associated with the presence of clinical atherosclerotic disease, cardiovascular risk factors and acute coronary syndromes. However, there is little consensus in the literature, including between the large well-designed population studies. This may be explained either by unrecognized confounding factors or, alternatively, by the unpredictable relationship between cell surface expression and activity of cellular adhesion molecules and their shedding into the plasma under different circumstances. Probably for the latter reasons, there is at present little evidence that the measurement of circulating adhesion molecules is likely to offer any additional benefit for individual patients above the assessment of conventional cardiovascular risk factors in the assessment of either the extent of, or future risk from, cardiovascular disease.

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Section: Coronary Angiography and Angioplastymentioning

confidence: 99%

Cellular adhesion molecules and cardiovascular disease. Part II. Their association with conventional and emerging risk factors, acute coronary events and cardiovascular risk prediction

Hope

Meredith

2003

Internal Medicine Journal

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“…Although previous studies have shown increased levels of vWf following angiography in patients with and without atherosclerosis [2] and sP-sel in patients with both coronary disease and PVD [1], there was an unexpected drop in both sP-sel and vWf immediately following the procedure. This might be explained by the patient being 'rested' on the angiography table but does not explain the discrepancy with other studies.…”

Section: Discussionmentioning

confidence: 60%

“…Another study of patients with intermittent claudication undergoing angioplasty showed an increased level of vWf levels taken from the arterial puncture immediately after the procedure, suggesting endothelial disturbance, but this rise was not sustained in venous samples obtained 4 months later and was independent of subsequent restenosis [20]. Coronary angioplasty and angiography also appears to cause an increase in vWf after 4 h [7] and 24 h [2].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of contrast media and the angiography process on markers of endothelial and platelet function and thrombogenesis have been studied in both peripheral [1] and coronary artery disease [2,3]. There has been little agreement between the results of the different studies of angiography in endothelial and platelet function.…”

Section: Introductionmentioning

confidence: 99%

“…It is apparent that none have investigated the effect of intervention (angioplasty and stenting) in patients with PVD compared with angiography. There have been some studies investigating the effects of coronary angioplasty and stenting on platelet activation [2,[4][5][6] and markers of endothelial function [2,[7][8][9] but not in PVD. Some contrast media are known to cause disturbances in platelet and endothelial function in vivo as well as in vitro [10] and further hypotheses have been tested that the X-ray themselves may be responsible, although this remains largely unproven.…”

Section: Introductionmentioning

confidence: 99%

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Indices of Thrombogenesis, Endothelial Damage and Platelet Function following Percutaneous Peripheral Artery Angiography and Angioplasty for Peripheral Vascular Disease

Makin¹,

Chung²,

Silverman³

et al. 2003

Pathophysiol Haemos Thromb

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We hypothesised that there would be alterations in markers of endothelial damage/dysfunction, platelet activation and thrombogenesis in patients with peripheral vascular disease (PVD) as a result of undergoing diagnostic angiography and therapeutic angioplasty. To test this hypothesis, we measured sequential changes in von Willebrand factor (vWf, an index of endothelial damage/dysfunction), tissue factor (TF, an index of thrombogenesis) and soluble P-selectin (sP-sel, an index of platelet activation) in 52 consecutive patients (32 male; mean age 69 years, SD 10) who were undergoing elective angiography and angioplasty for PVD. Patients with PVD had significantly higher vWf and sP-sel levels compared to healthy controls (both p < 0.001), but median TF levels were not significantly different (p = 0.344). In the whole group, there was a significant reduction in sP-sel levels (p < 0.001, paired t test) post-angiography/angioplasty, but no significant change in vWf and TF levels. In patients undergoing angiography only, there was a significant drop in mean sP-sel (p < 0.001, paired t test) and vWf (p = 0.044) values after the procedure, whilst TF levels were not significantly changed (p = 0.370, Mann-Whitney U test). In patients undergoing angioplasty and stent, mean sP-sel levels fell immediately after the procedure (p = 0.001, paired t test), but there were no statistically significant changes in vWf and TF-levels. In conclusion, there appears to be a reduction in plasma sP-sel levels following angioplasty and stenting for PVD, suggesting alterations in platelet physiology, which may be accompanied by some alterations in the endothelium. The possibility that these changes may have pathophysiological implications for understanding platelet and endothelial reactions to angiography and associated interventions (that is, angioplasty and stent) needs to be explored.

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Inflammatory Markers and Mortality in Critical Lower Limb Ischemia

Gottsäter

2013

Inflammatory Response in Cardiovascular Surgery

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Immediate and late effects of coronary angiography on soluble endothelial cell markers and P-selectin in patients with and without coronary artery disease

Cited by 10 publications

References 0 publications

Cellular adhesion molecules and cardiovascular disease. Part II. Their association with conventional and emerging risk factors, acute coronary events and cardiovascular risk prediction

Cellular adhesion molecules and cardiovascular disease. Part II. Their association with conventional and emerging risk factors, acute coronary events and cardiovascular risk prediction

Indices of Thrombogenesis, Endothelial Damage and Platelet Function following Percutaneous Peripheral Artery Angiography and Angioplasty for Peripheral Vascular Disease

Inflammatory Markers and Mortality in Critical Lower Limb Ischemia

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