Immediate and long-lasting effects of chronic stress in the prepubertal age on the startle reflex

Maslova, L. N.; Булыгина, В. В.; Попова, Н. К.

doi:10.1016/s0031-9384(01)00648-5

Cited by 40 publications

(20 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This contrasts with previous reports of increased anxiety (Giovanoli et al, 2013;Jacobson-Pick et al, 2008;Maslova et al, 2002aMaslova et al, , 2002bTsoory et al, 2007;Yee et al, 2011), although negative or inconsistent results have also been reported (Avital and Richter-Levin, 2005;Bourke and Neigh, 2011;Jacobson-Pick and Richter-Levin, 2010;McCormick et al, 2007;Peleg-Raibstein and Feldon, 2011;Pohl et al, 2007;Toledo-Rodríguez and Sandi, 2007). This is likely related to a differential susceptibility to stress among the different strains of rats and mice used (e.g., Maslova et al, 2002aMaslova et al, , 2002b.…”

Section: Accepted M Manuscriptcontrasting

confidence: 86%

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Fuentes

Carrasco

Armario

et al. 2014

Hormones and Behavior

View full text Add to dashboard Cite

Exposure to stress during childhood and adolescence increases vulnerability to developing several psychopathologies in adulthood and alters the activity of the hypothalamic-pituitaryadrenal (HPA) axis, the prototypical stress system. Rodent models of juvenile stress appear to support this hypothesis because juvenile stress can result in reduced activity/exploration and enhanced anxiety, although results are not always consistent. Moreover, an in-depth characterization of changes in the HPA axis is lacking. In the present study, the long-lasting effects of juvenile stress on adult behavior and HPA function were evaluated in male rats. The juvenile stress consisted of a combination of stressors (cat odor, forced swim and footshock) during postnatal days 23-28. Juvenile stress reduced the maximum amplitude of the adrenocorticotropic hormone (ACTH) levels (reduced peak at lights off), without affecting the circadian corticosterone rhythm, but other aspects of the HPA function (negative glucocorticoid feedback, responsiveness to further stressors and brain gene expression of corticotrophin-releasing hormone and corticosteroid receptors) remained unaltered. The behavioral effects of juvenile stress itself at adulthood were modest (decreased activity in the circular corridor) with no evidence of enhanced anxiety. Imposition of an acute severe stressor (immobilization on boards, IMO) did not increase anxiety in control animals, as evaluated one week later in the elevated-plus maze (EPM), but it potentiated the acoustic startle response (ASR). However, acute IMO did enhance anxiety in the EPM, in juvenile stressed rats, thereby suggesting that juvenile stress sensitizes rats to the effects of additional stressors.

show abstract

Section: Accepted M Manuscriptcontrasting

confidence: 86%

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Fuentes

Carrasco

Armario

et al. 2014

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

“…We observed that CORT had no effect on the baseline startle response in both WT and BDNF HET rats. In contrast, Maslova et al (2002) have shown that an early-life chronic variable stress paradigm in young Wistar rats can increase the startle response 3 months later during adulthood and have suggested that such behavior may be of relevance to the study of PTSD. Possible reasons for the discrepancy could include the different stress paradigm used and strain differences.…”

Section: Prepulse Inhibition -Sensorimotor Gatingmentioning

confidence: 95%

Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment

2015

View full text Add to dashboard Cite

“…A number of animal models have begun to support this assertion, in that anxiety-and depressive-like behaviors are greater in animals that experience stress during adolescence compared to unstressed controls (Avital, Ram, Maayan, Weizman, & Richter-Levin, 2006;Leussis & Andersen, 2008;Maslova, Bulygina, & Markel, 2002;Maslova, Bulygina, & Popova, 2002;McCormick, Smith, & Mathews, 2008;Pohl, Olmstead, Wynne-Edwards, Harkness, & Menard, 2007;Schmidt et al, 2007;Stone & Quartermain, 1998;Toledo-Rodriguez & Sandi, 2007;Tsoory, Cohen, & Richter-Levin, 2007;Vidal et al, 2007;Wright, Hebert, & Perrot-Sinal, 2008). Interestingly, once animals have progressed through the pubertal stage of maturation they may be less susceptible to stress-induced changes in emotionality.…”

Section: Behavioral and Neurobiological Consequences Of Pubertal Stressmentioning

confidence: 99%

Adolescence: A central event in shaping stress reactivity

Romeo

2010

Developmental Psychobiology

267

211

View full text Add to dashboard Cite

ABSTRACT:The magnitude and duration of the hormonal stress response change dramatically throughout an organism's lifespan. Although much is known about the factors that modulate stress reactivity during adulthood and how neonatal development and aging influence stress responsiveness, we know relatively little about how stress reactivity changes during the juvenile to adult transition. Recent studies in adolescent boys and girls have suggested that stress is an important factor contributing to an individual's vulnerability to various neuropsychological dysfunctions, including anxiety, depression, and drug abuse. Thus, understanding how exposure to stressors during this crucial period of development lead to negative consequences is of paramount importance. A growing body of literature indicates that pubertal organisms react differentially, both physiologically and behaviorally, to a stressor compared to adults. The purpose of this review, therefore, is to discuss the recent findings regarding the pubertal maturation of stress reactivity, while also highlighting future research directions that will aid in our understanding of stress and adolescent mental health and development. ß 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 244-253, 2010.

show abstract

Immediate and long-lasting effects of chronic stress in the prepubertal age on the startle reflex

Cited by 40 publications

References 93 publications

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment

Adolescence: A central event in shaping stress reactivity

Contact Info

Product

Resources

About