Immediate and long range effects of the uptake of increased amounts of arachidonic acid

Adam, O.

doi:10.1007/bf00180737

Cited by 17 publications

(14 citation statements)

References 47 publications

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“…Inhibition of LA desaturation, seems relevant in humans, as in our experiments the DHGLA and AA levels were decreased with the LFD 20. The biosynthesis of AA from LA is sluggish [11], but increases with fasting [13] or diets devoid of polyunsaturated fatty acids [9]. This was confirmed by the increase of the AA concentrations with the LFD 0 in our experiments.…”

Section: Discussionsupporting

confidence: 74%

“…It is very unlikely that release of AA from fat stores contributes appreciable to the increase in AA levels, as both LFD 0 and LFD 20 provided the same amount of energy, and our volunteers did not loose weight during the LFD 0. Moreover, it is known that release of AA from fat stores is very limited, as AA mostly is stored in the sn-3 position of triglycerides which is not accessible for lipases [9]. It is interesting that exclusion of LA from the diet augments AA percentages in CE of plasma, but lowers PG biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

“…Exaggerated eicosanoid formation promotes platelet aggregation and mediates immunological, proliferative, and allergic responses of cells [9]. Transformation of LA to AA is an enzymatic process, dependent on the activity of ‰-6-desaturase, an enzyme inhibited by all polyunsaturated fatty acids, including LA [10,11].…”

Section: Discussionmentioning

confidence: 99%

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Influence of Dietary Linoleic Acid Intake with Different Fat Intakes on Arachidonic Acid Concentrations in Plasma and Platelet Lipids and Eicosanoid Biosynthesis in Female Volunteers

2003

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Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA). We investigated the impact of the linoleic acid (LA) intake on AA levels in humans. Methods: Six healthy female volunteers (age range 23–34 years) were given liquid formula diets (LFD) devoid of AA for 6 weeks, providing a constant intake of zero energy% (LFD 0: protein 15%, carbohydrates 85%) or 20 energy% (LFD 20: protein 15%, carbohydrates 55%, fat 30%) LA, for 3 weeks each. Fatty acids of plasma cholesteryl esters and platelet lipids were determined each week, and the prostaglandin biosynthesis was measured in 24-hour urine samples. Results: LFD 0 increased (+31% of initial value) and LFD 20 lowered (–30% of initial value) the percentage of AA in plasma cholesteryl esters and platelet lipids. Moreover, absence of dietary AA lowered the percentages of AA in plasma (–31% week 0 vs. week 6) and platelet (–11%) lipids, indicating a low transformation of LA. LFD 0 reduced urinary metabolite levels of prostaglandins D, E, and F in 24-hour urine samples (–48%, p < 0.001) within 24 h, but did not significantly affect platelet aggregation (–10%) and thromboxane formation (–25%). LFD 20 significantly lowered platelet aggregation (–25%) and thromboxane formation (–43%). The prostaglandin metabolite levels increased during the first 10 days, declined thereafter, and were lower than the preexperimental values at the end of the 3-week period. Conclusions: The results show that dietary LA does not increase the AA levels in plasma or platelet lipids and does not persistently contribute to prostaglandin biosynthesis which is increased by AA intake with Western diets.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Influence of Dietary Linoleic Acid Intake with Different Fat Intakes on Arachidonic Acid Concentrations in Plasma and Platelet Lipids and Eicosanoid Biosynthesis in Female Volunteers

2003

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“…Untersuchungen in Zellkulturen, Tiermodellen und am Men− schen haben gezeigt, dass die Menge der in der Zellmembran veresterten Arachidonsäure das Ausmaß der Eicosanoidbiosyn− these bestimmt, die durch einen gegebenen Stimulus in den Im− munzellen ausgelöst wird [12]. Je mehr Arachidonsäure sich in der Zellmembran befindet, umso mehr Eicosanoide werden ge− bildet [13].…”

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Rheuma und Entzündungskontrolle durch Ernährung

Adam¹

2009

Aktuel Ernahrungsmed

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“…Likewise, vegetarians with high linoleic acid intake have lower arachidonic plasma levels compared to omnivores with lower linoleic acid intake [4][5][6]. The effect of linoleic acid on eicosanoid production is marginal, while dietary arachidonic acid dramatically increases eicosanoid production [7,8]. It is hard to understand why the working group disregarded arachidonic acid, but gives very precise proposals for less important fatty acids.…”

mentioning

confidence: 99%

Linoleic Acid – The Fall of an Angel?

Adam¹

1999

Ann Nutr Metab

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Immediate and long range effects of the uptake of increased amounts of arachidonic acid

Cited by 17 publications

References 47 publications

Influence of Dietary Linoleic Acid Intake with Different Fat Intakes on Arachidonic Acid Concentrations in Plasma and Platelet Lipids and Eicosanoid Biosynthesis in Female Volunteers

Influence of Dietary Linoleic Acid Intake with Different Fat Intakes on Arachidonic Acid Concentrations in Plasma and Platelet Lipids and Eicosanoid Biosynthesis in Female Volunteers

Rheuma und Entzündungskontrolle durch Ernährung

Linoleic Acid – The Fall of an Angel?

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