Immediate and long-term efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with the cat flea Ctenocephalides felis

Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats

“…Comparable to the isoxazolines, tigolaner has a large volume of distribution, high level of protein binding and slow excretion, which provides it with the persistent characteristics required to protect cats from an established ectoparasite infestation and subsequent reinfestations. The observed long half-life and high volume of distribution of tigolaner translate into concentrations high enough to offer a three-months protection against fleas and ticks following topical application ( Cvejić et al., 2022b ; Mencke et al., 2023 ). As it emerges that fleas are prevalent all year round ( ESCCAP, 2022 ), and for ticks a widespread and longer seasonal activity of Ixodes ricinus and Dermacentor reticulatus is observed e.g.…”

“…Tigolaner has a high potency against insects and acarids by exposure via their feeding, i.e. fleas and ticks that initiate feeding will be exposed to the AI ( Cvejić et al., 2022a , b ; Mencke et al., 2023 ). A single tigolaner dose administered topically at the minimum recommended dose of 14.5 ​mg/kg body weight (BW) on cats provides 13 weeks of flea and tick control ( Cvejić et al., 2022a , b ; Mencke et al., 2023 ).…”

“…fleas and ticks that initiate feeding will be exposed to the AI ( Cvejić et al., 2022a , b ; Mencke et al., 2023 ). A single tigolaner dose administered topically at the minimum recommended dose of 14.5 ​mg/kg body weight (BW) on cats provides 13 weeks of flea and tick control ( Cvejić et al., 2022a , b ; Mencke et al., 2023 ). A fast onset of flea efficacy, the so called speed of flea kill is of clinical relevance to reduce exposure to flea saliva (flea allergic dermatitis) and transmission of pathogens (vector-borne diseases).…”

“…Studies clearly demonstrated the fast onset of efficacy within 12 ​h with respect to fleas that are already on the cat prior to treatment. For new flea infestation the onset was within 8 ​h for two months and within 24 ​h afterwards ( EMA, 2022 ; Mencke et al., 2023 ). The fast onset together with the long duration of activity after a single topical administration offers a convenient alternative to monthly flea and tick control treatments and is expected to increase pet owner compliance ( Lavan et al., 2020 , 2021 ).…”

Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis)

“…Felpreva® is a new broad-spectrum spot-on formulation, which was recently registered for cats in Europe, containing tigolaner, emodepside, and praziquantel at the minimum recommended dose of 14.4 mg/kg, 3 ​mg/kg, and 12 ​mg/kg body weight, respectively ( EMA, 2021 ). The product has been demonstrated to have high anthelmintic activity in cats ( Cvejić et al., 2022a ; Traversa et al., 2022 ) and high efficacy against common tick and flea species in Europe ( Cvejić et al., 2022b ), in combination with a fast onset of flea kill ( Mencke et al., 2023 ). The purpose of this article is to present the miticidal activity of the product.…”