Immediate and long-term outcome of corrosive ingestion

Kumar, C Bharath; Chowdhury, Sudipta Dhar; Ghatak, Soumya; Devarakonda, Sreekar; Kurien, Reuben Thomas; David, Deepu; Dutta, Amit Kumar; Simon, Ebby George; Joseph, Anjilivelil Joseph

doi:10.1007/s12664-019-00978-z

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…As well, saliva drooling and dysphagia were found to be strongly related to increased morbidity and mortality post caustic ingestion by Sagar et al (2016) and Mantho et al (2022). However, Controversy exists regarding the predictive value of symptoms and signs following caustic ingestion; several studies reported that clinical manifestations are variable, non-reliable predictors for the degree and depth of injury and do not necessarily correlate with severity and outcomes of corrosive poisoning (Bharath-Kumar et al, 2019;Rezan et al, 2020 andPatel, 2021).…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

Saleh,

Abdel Salam,

Abou Anza

et al. 2024

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Caustic ingestion in children is considered a serious healthcare issue worldwide due to its high morbidity and mortality rates. Aim: The present study aimed to evaluate the potential role of procalcitonin (PCT) compared to C-reactive protein (CRP) and neutrophil lymphocyte ratio (NLR) in assessment of severity and prediction of outcomes of acute corrosive ingestion for early intervention and better prognosis. Methods: This prospective study was conducted on 60 patients aged from 6 months to 12 years, who were admitted to poison control center, Ain Shams University Hospitals with diagnosis of acute caustic ingestion. Demographic, clinical data and blood samples were collected from each patient, with biomarkers' assessment within 24 hours post caustic ingestion. Results: The majority of patients were males (70%) with median age 1.5 years. Acute and/or chronic complications occurred in 43.3% of the studied patients. Significantly higher levels of PCT, CRP and NLR were detected in complicated patients, as well patients with DROOL score ≤4. Procalcitonin level <1.4 ng/mL was the most specific biomarker (94.12%) with the highest positive predictive value (90.5%) in predicting complications occurrence, whereas CRP level <9.6 mg/L was the most sensitive biomarker (100%). Conclusion: This study supports the role of PCT, CRP and NLR as reliable biomarkers in early predicting the severity and outcomes of corrosive ingestion in children. PCT seemed to be superior to CRP and NLR in predicting complications post caustic ingestion.

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Section: Discussionmentioning

confidence: 99%

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

Saleh,

Abdel Salam,

Abou Anza

et al. 2024

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…In our study, in children, pharmaceutical poisoning was more common in females but non-pharmaceutical poisoning was more observed in males. Kumar and colleagues found that most cases involving household products were in children under 5 years old 25 . Regression analysis revealed that both non-pharmaceutical poisoning and male gender were predictive factors for mortality in all patients.…”

Section: Discussionmentioning

confidence: 99%

Clinico-epidemiological evaluation of pharmaceutical/non-pharmaceutical poisoning in a referral poisoning emergency in the Central part of Iran

Eizadi-Mood,

Sanjari,

Feizi

et al. 2024

Sci Rep

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The pattern of poisoning varies in different societies. In this study, we investigated the clinical-epidemiological features and outcomes of poisoned patients based on the substances involved, whether pharmaceutical or non- pharmaceutical toxins. This cross-sectional study involved a retrospective chart review of all poisoned patients who presented to the poisoning emergency hospital in the center of Iran between January 2015 and December 2019. We collected data on socio-demographics, the nature of the poisoning, and the outcomes. Backward stepwise binary regression analysis was conducted to predict the mortality. Throughout the study period, 5777 patients with acute poisoning met the inclusion criteria. Of these, 3524 cases (61%) were attributed to pharmaceutical, and 2253 cases (39%) were due to non-pharmaceutical poisoning. The majority of pharmaceutical poisonings (82.9%) were intentional, whereas non-pharmaceutical poisonings accounted for 46.2% of intentional exposures (P < 0.001). Patients with non-pharmaceutical poisoning were predominantly men, older in age, and had a history of addiction compared to those with pharmaceutical poisoning (P < 0.001). In binary logistic regression analysis, patients poisoned by non-pharmaceutical substances had a significantly higher risk of mortality [Odds ratio, 3.14; (95% CI 1.39–7.10); P = 0.006] compared to those poisoned by pharmaceutical substances (P < 0.001). The pattern of poisoning differs in terms of age and gender when comparing pharmaceutical to non-pharmaceutical poisoning. Patients poisoned by non-pharmaceutical may have a worse outcome compared to those poisoned by pharmaceutical substances.

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Surgical management of esophageal stenosis due to ingestion of corrosive substances

Tustumi

Seguro

Szachnowicz

et al. 2021

Journal of Surgical Research

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Immediate and long-term outcome of corrosive ingestion

Cited by 5 publications

References 23 publications

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

Clinico-epidemiological evaluation of pharmaceutical/non-pharmaceutical poisoning in a referral poisoning emergency in the Central part of Iran

Surgical management of esophageal stenosis due to ingestion of corrosive substances

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