Immediate and Long-term Results of Radiofrequency Ablation for Colorectal Liver Metastases

Cirimbei, C; Rotaru, Vlad; Chitoran, Elena; Pavaleanu, Oana; Cirimbei, Simona

doi:10.21873/anticanres.12105

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…8 As reported previously, we revealed that patients with tumor sizes larger than 3 cm had a poor prognosis. [29][30][31] However, another prognostic factor, the number of liver tumors, was not an independent predictor of survival in this study. This discrepancy may have been due to the relatively lower lesion-topatient ratio (1.56, 125/80) in this study.…”

Section: Discussioncontrasting

confidence: 74%

Clinical Outcomes and Predictors in Patients With Unresectable Colorectal Cancer Liver Metastases Following Salvage Percutaneous Radiofrequency Ablation: A Single Center Preliminary Experience

Wang

Zhang

et al. 2020

Technol Cancer Res Treat

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Purpose: The purpose of this study was to investigate the clinical efficacy of salvage percutaneous radiofrequency ablation in patients with unresectable colorectal cancer liver metastases. Methods: The cohort consisted of 81 patients with 126 colorectal cancer liver metastases who underwent radiofrequency ablation between January 2012 and September 2016. The clinical data and ablation data were retrospectively analyzed. The local tumor progression-free survival, overall survival, and prognostic factors were analyzed using the log-rank test and Cox regression model. Results: The technique success rate was 99.21%. The primary efficacy rate was 100% at the 1-month follow-up. Minor complications were observed in 2 patients, which recovered within 1 week. The median local tumor progression-free survival time of all patients was 29.8 months. The absence of subsequent chemotherapy was an independent predictor of a shorter local tumor progression-free survival time ( P < 0.001, hazard ratio: 2.823, 95% confidence interval: 1.603, 4.972). The median overall survival time was 26.8 months. A lesion size greater than 3 cm ( P = 0.011, hazard ratio: 2.112, 95% confidence interval: 1.188, 3.754) and the presence of early local tumor progression ( P = 0.011, hazard ratio: 2.352, 95% confidence interval: 1.217, 4.545) were related to a shorter survival time. Conclusions: Percutaneous radiofrequency ablation is safe in patients with colorectal cancer liver metastases refractory from chemotherapy. Subsequent chemotherapy is important to enhance local control. Small lesions and favorable early responses are related to prolonged overall survival.

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Section: Discussioncontrasting

confidence: 74%

Clinical Outcomes and Predictors in Patients With Unresectable Colorectal Cancer Liver Metastases Following Salvage Percutaneous Radiofrequency Ablation: A Single Center Preliminary Experience

Wang

Zhang

et al. 2020

Technol Cancer Res Treat

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“…Almost 30 years have passed since the introduction of RFA, and data have been accumulated steadily regarding CRC liver metastasis and not only hepatocellular carcinoma, which is in high demand for RFA. Cirimbei reported in a retrospective study regarding immediate and long-term results of RFA for unresectable or non-operable liver metastasis of CRC, and indicated that RFA is safe, has low rates of local relapses and recurrences, and acceptable survival rates (23). As a minimally invasive local treatment, the main roles of RFA for unresectable or non-operable cases of CRC with liver metastasis are to assist as a complementary local treatment and to control liver metastases in cases with a defined prognosis due to liver metastases.…”

Section: Discussionmentioning

confidence: 99%

Significance of Radiofrequency Ablation for Unresectable Colorectal Cancer With Liver Metastases

et al. 2021

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“…Malignant tumors have an abundant blood supply and large number of AV fistula structures, making it easy to relapse or even accelerate the treatment progress. In recent years, ablation therapy has been used in the clinical treatment of a variety of malignant tumors, and the method has achieved good results [ 25 ]. Inspired by these findings, we applied this technique to cases of complex AV malformations in which other methods had failed many times; the process was conducted in December 2014 after multidisciplinary consultation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of 18 complex diffuse arteriovenous malformation cases treated with percutaneous radiofrequency ablation

Chen

et al. 2021

BMC Cardiovasc Disord

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Background The aim of the present study is to evaluate the short-term efficacy and feasibility of radiofrequency ablation in the treatment of complex diffuse arteriovenous (AV) malformations. Methods The data of 18 patients (8 male and 10 female) with complex AV malformations treated between December 2014 and June 2019 were analyzed retrospectively. The lesion area was 10 × 7 cm ~ 28 × 30 cm. Under duplex ultrasound guidance, the site with the most abundant blood flow signals in the lesion was percutaneously punctured with the radiofrequency ablation needle (electrode). The impedance automatic adjustment mode was adopted, and ablation was monitored usingduplex ultrasoundduring the entire process. Results Of the included patients, 1 had a high fever after two rounds of treatment, 2 had transient hemoglobinuria, and 1 had tissue necrosis in the original ruptured tumor area as well as a penetrating defect in the cheek, which was repaired with a pedicled trapezius myocutaneous flap. In 9 patients who experienced bleeding, the bleeding stopped after one round of treatment. During the follow-up period of 1–5 years, there were 0 grade I (poor) cases, 0 grade II (medium) cases, 7 grade III (good) cases, and 11 grade IV (excellent) cases. Conclusion The “high power and continuous” radiofrequency ablation technique conducted under real-time duplex ultrasoundmonitoring can completely destroy the deep core lesions of AV malformations and effectively control life-threatening massive hemorrhage; it is an effective alternative treatment method for complex diffuse AV malformations in which interventional embolization, sclerotherapy, and surgery are ineffective.

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Immediate and Long-term Results of Radiofrequency Ablation for Colorectal Liver Metastases

Abstract: RFA of CRLMs is a safe procedure with low rates of local relapses and recurrences, as well as acceptable survival rates, in the first 24-36 months post-procedure. It is recommended for patients with no indications for liver resection or having major resection risks.

Cited by 7 publications

References 9 publications

Clinical Outcomes and Predictors in Patients With Unresectable Colorectal Cancer Liver Metastases Following Salvage Percutaneous Radiofrequency Ablation: A Single Center Preliminary Experience

Clinical Outcomes and Predictors in Patients With Unresectable Colorectal Cancer Liver Metastases Following Salvage Percutaneous Radiofrequency Ablation: A Single Center Preliminary Experience

Significance of Radiofrequency Ablation for Unresectable Colorectal Cancer With Liver Metastases

Analysis of 18 complex diffuse arteriovenous malformation cases treated with percutaneous radiofrequency ablation

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