Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A quasi‐randomized controlled trial

Ulin, Charlotte; Magunacelaya‐Barria, M.; Dahlén, Gunnar; Kvist, Thomas

doi:10.1111/iej.13258

Cited by 28 publications

(26 citation statements)

References 38 publications

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“…The results agree with other studies where the effectiveness of NaOCl as antimicrobial agent has been demonstrated [24][25][26][27][28][29][30][31]. The alkaline pH of NaOCl induces biosynthetic alterations in cell metabolism, protein denaturation, enzymatic inhibition, and destruction of phospholipids, [32] intervening in the integrity of the cytoplasmic membrane, which grants its bactericidal effect and tissue dissolution, for that reason, it is the chemical agent most used during endodontic therapy [33,34]. Nevertheless, being a non-selective disinfectant agent, NaOCl, can lead to cellular alterations such as chromosomal aberration, frequency of micronuclei, necrotic or apoptotic cells, and binucleated cells [35].…”

Section: Discussionsupporting

confidence: 88%

Comparison of the Antimicrobial Effect of Chlorine Dioxide, Sodium Hypochlorite and Chlorhexidine, on Bacteria Isolated from the Root Canal

Rodríguez¹

2022

J Dent Oral Sci

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Aim: To compare the antimicrobial capacity of Chlorine Dioxide (ClO2), Sodium Hypochlorite (NaOCl) and Chlorhexidine (CHX) in microorganisms isolated from persistent apical periodontitis and ATCC strains. Materials and methods: The microorganisms included were analyzed by Minimum Inhibitory Concentration (MIC): 50 µl of saline solution and 100 µl of Chlorine Dioxide 0.25%, Sodium Hypochlorite 1% and Chlorhexidine 2% were used to make the following dilutions of 1:2, 1:4, 1:8, 1:16, 1:32, 1:64, 1:128, 1:256, 1:512, 1:1024 and test them with the following microorganisms, E. faecalis from root canal and S. viridans, anginosus group from the alveolus, in adittion, Escherichia coli ATCC and Staphylococcus aureus ATCC were included to observe bacterial growth after 18h of incubation. Results: NaOCl inhibited the microorganisms in all the dilutions, the ClO2 showed bacterial growth in dilution 1:128, CHX1:8, in E. faecalis, S. viridans, anginosus group, ClO2:1:32, CHX:1:8, Escherichia coli ATCC ClO2:1:32, CHX:1:128, Staphylococcus aureus ATCC ClO2:1:64 and CHX:1:256. Conclusion: NaOCl was the chemical agent that inhibited all the strains evaluated, followed by ClO2 and Chlorhexidine 2% needed higher concentrations for the eradication of the analyzed strains.

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Section: Discussionsupporting

confidence: 88%

Comparison of the Antimicrobial Effect of Chlorine Dioxide, Sodium Hypochlorite and Chlorhexidine, on Bacteria Isolated from the Root Canal

Rodríguez¹

2022

J Dent Oral Sci

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“…However, the effects are restricted to the main root canal, and instruments usually fail to touch all the walls, causing unprepared areas to harbor microorganisms (3). In addition to that, studies have revealed that chemomechanical preparation using NaOCl at different concentrations is not able to render root canals free of bacteria, and 40% to 60% of the root canals are still positive for bacterial presence (1,4).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of the Efficacy of Two Different Single-file Systems in Reducing the Bacterial load in Oval-Shaped Canals: A Clinical Study

Amaral

Oliveira

Braga

et al. 2020

Journal of Endodontics

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Introduction: This randomized clinical study compared the in vivo antibacterial efficacy of Reciproc Blue (RB), XP-endo Shaper (XP-S),XP-endo Shaper associated with XP-endo Finisher (XP-F) systems in infected oval-shaped root canals with primary apical periodontitis.Methods: In this study, 28 human teeth with a single root and a single canal were randomly assigned to two groups according to the instrumentation technique: group-1, RB (n = 14) and group-2, XP-endo (XP-S and XP-F, n = 14). The single-rooted teeth were prepared by reciprocating and rotary nickel-titanium (NiTi) instruments with 5.25% sodium hypochlorite irrigation. Samples were collected from the canal at the baseline (S1), after chemomechanical preparation (S2), and after XP-F instrumentation (S3). The DNA extracts were subjected to quantitative analysis for total bacterial counts by quantitative real-time polymerase chain reaction. The data were analyzed using the analysis of variance test (ANOVA), and the level of significance was set at 5%. Results:All samples tested positive for the presence of bacteria at baseline, and the bacterial counts substantially reduced after treatment procedures (P < 0.01). The results showed no statistical difference between RB and XP-S instrumentation with respect to the bacterial reduction (P ˃ 0.05). A marked bacterial reduction was observed after the use of the XP-F instrument (P < 0.01). Conclusion:The XP-S and RB systems sharply reduced the bacterial load in oval-shaped root canals with primary apical periodontitis. XP-F, used as a supplementary instrument to chemomechanical preparation, promoted a significantly higher bacterial reduction.

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“…Also, despite sodium hypochlorite (NaOCl) being the chemical substance used in all studies, its concentration ranged from 1% to 5%. It has been shown that the concentration of NaOCl does not appear to influence the reduction of the microbial load of the root canal system [ 61 62 ], but the volume of irrigant solution, the frequency of irrigant renewal, and the time that it remains inside the root canal are factors that play an essential role during treatment [ 63 64 ]. However, the included studies did not describe these aspects.…”

Section: Discussionmentioning

confidence: 99%

Influence of the root canal filling technique on the success rate of primary endodontic treatments: a systematic review

et al. 2022

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Objectives This study aimed to investigate the influence of different obturation techniques compared to cold lateral compaction on the success rate of primary non-surgical endodontic treatments. Materials and Methods Systematic searches were performed for studies published up to May 17 th , 2022 in MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE, and Grey Literature Reports. Randomized clinical trials and nonrandomized (nonrandomized clinical trials, prospective or retrospective) studies that evaluated the success rate of primary non-surgical endodontic treatments obturated with the cold lateral compaction (control) and other obturation techniques were included. The revised Cochrane risk of bias tools for randomized trials (RoB 2) and nonrandomized studies of interventions (ROBINS-I) were used to evaluate the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the certainty of evidence. Results Eleven studies (4 randomized clinical trials (RCTs), 4 prospective, and 3 retrospectives) were included. Two RCTs were classified as having some concerns risk of bias and 2 as a low risk of bias. Two nonrandomized studies were classified as having a critical risk of bias and 5 as having a moderate risk of bias. The GRADE analysis demonstrated a very low to moderate certainty of evidence. Conclusions This systematic review generally evidenced no differences in the success rate of primary non-surgical endodontic treatments when the cold lateral compaction technique and other obturation techniques are performed. Further well-designed studies are still necessary.

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Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A quasi‐randomized controlled trial

Abstract: Ulin C, Magunacelaya-Barria M, Dahl en G, Kvist T.Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A quasi-randomized controlled trial.

Cited by 28 publications

References 38 publications

Comparison of the Antimicrobial Effect of Chlorine Dioxide, Sodium Hypochlorite and Chlorhexidine, on Bacteria Isolated from the Root Canal

Comparison of the Antimicrobial Effect of Chlorine Dioxide, Sodium Hypochlorite and Chlorhexidine, on Bacteria Isolated from the Root Canal

Quantitative Assessment of the Efficacy of Two Different Single-file Systems in Reducing the Bacterial load in Oval-Shaped Canals: A Clinical Study

Influence of the root canal filling technique on the success rate of primary endodontic treatments: a systematic review

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