Immediate cytology improves accuracy and decreases complication rate in real‐time computed tomography‐guided needle lung biopsy

Tachibana, Kaori; Nakazato, Yoshimasa; Tsuchida, Shigeru; Kazama, Toshifumi; Minato, Koichi; Yoshida, Tsutomu; Fujita, Atsushi; Horikoshi, Hiroyuki; Tanaka, Ryota; Iijima, Misa; Goya, Tomoyuki

doi:10.1002/dc.22940

Cited by 11 publications

(9 citation statements)

References 21 publications

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“…Liquid‐based smear samples should immediately be placed in digestive or preservative solutions and sent to the laboratory for further processing according to the operating procedures. Both rapid on‐site evaluation of cytology (ROSE) and on‐site imprint cytology involving cytopathologists can improve diagnostic accuracy . Specimens for histopathological examination should be fixed immediately after they are obtained by placing the samples in a 10% neutral buffered formalin fixative.…”

Section: Biopsy Proceduresmentioning

confidence: 99%

Chinese multidisciplinary expert consensus: Guidelines on percutaneous transthoracic needle biopsy

Guo

Shi

et al. 2018

Thoracic Cancer

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Biopsy has been used to diagnose thoracic diseases for more than a century. Percutaneous needle biopsy plays a crucial role in the diagnosis, staging, and treatment planning for tumors in the lungs, thoracic wall, hilum, and mediastinum. With the continuous improvement in imaging techniques, the range of clinical applications for percutaneous needle biopsy is also expanding. It has become important to improve Chinese professionals’ and technicians’ understanding of percutaneous transthoracic needle biopsy (PTNB) in order to standardize operating procedures and to strengthen perioperative management. However, there is currently no Chinese expert consensus that provides systematic standardization and guidance for PTNB in clinical practice. The Committee of Chinese Society of Interventional Oncology (CSIO) of the Chinese Anti‐Cancer Association (CACA) initiated a Chinese multidisciplinary expert consensus on PTNB. The consensus includes image‐guided methods, indications, contraindications, multidisciplinary team recommendations, biopsy procedures, daytime/outpatient biopsy, complications, pathological examination, and management of negative results.

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Section: Biopsy Proceduresmentioning

confidence: 99%

Chinese multidisciplinary expert consensus: Guidelines on percutaneous transthoracic needle biopsy

Guo

Shi

et al. 2018

Thoracic Cancer

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“…The pooled incidence of non-diagnostic results was 6.8% (95% CI, 6.0–7.6%; I 2 = 0.91; 24668 biopsies in 106 studies) 4,6–8,11,12,19,22–24,26–35,38,40–42,44–49,52,54,55,59–62,65–67,69–86,89,91–97,99–103,106–113,115–118,120,122–126,128–133,135–143,146,147 .…”

Section: Resultsmentioning

confidence: 99%

“…With regard to other pathology findings, the malignancy rate was the highest for specific malignancy (99.8%, 95% CI, 99.7–99.9%; I 2 = 0.00; 11,884 biopsies in 114 studies) 3,4,6–9,11–23,25–68,70,72–76,78,79,81–86,88,90–93,96,99–101,103–105,108,113–115,118–120,124,126–130,132,134,138–147 , followed by atypical cells (91.1%, 95% CI, 87.8–94.5%; I 2 = 0.23; 312 biopsies in 41 studies) 4,9,13,14,17–20,26,27,29,30,34,37,41,42,46,47,53,64,66,70,74–76,79,85,86,89–91,98,101,104,108,115,120,126,129,144,147 , AAH (88.9%, 95% CI, 76.7–100.0%; I 2 = 0.31; 18 biopsies in 6 studies) 8,76,84,126,128,138 , non-specific benign results (20.6%, 95% CI, 17.8–23.4%; I 2 = 0.96; 2574 biopsies in 64 studies) 4,6,8,11,12,19,22,23,26–28,…”

Section: Resultsmentioning

confidence: 99%

Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Chae

Hong

Yoon

et al. 2019

Sci Rep

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Non-diagnostic results can affect the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) but have not been critically meta-analyzed yet. To meta-analyze the incidence and malignancy rate of non-diagnostic results, 3-by-2 table approaches rather than the conventional 2-by-2 approaches are needed to know its impact on the diagnostic performance of PTNB. A systematic literature search identified studies evaluating the diagnostic performance of PTNB with extractable outcomes. A total of 143 studies with 35,059 biopsies were included. The pooled incidence of non-diagnostic results was 6.8% (95% CI, 6.0–7.6%; I 2 = 0.91). The pooled malignancy rate of non-diagnostic results was 59.3% (95% CI, 51.7–66.8%; I 2 = 0.80), and was correlated with the prevalence of malignancy (correlation coefficient, 0.66; 95% CI, 0.42–0.91). Pooled percentage decrease of sensitivity and specificity due to non-diagnostic results were 4.5% (95% CI, 3.2–5.7%; I 2 = 0.64) and 10.7% (95% CI, 7.7–13.7%; I 2 = 0.70), respectively, and the pooled incidence of non-diagnostic results was 4.4% (95% CI, 3.2–5.8%; I 2 = 0.83) in lesions ultimately diagnosed as malignancies and 10.4% (95% CI, 7.5–13.8%; I 2 = 0.74) in benign disease. In conclusion, non-diagnostic results averagely occurred in 6.8% of PTNB and more than half of the results were malignancies. The non-diagnostic results decreased specificity and sensitivity by 10.7% and 4.5%, respectively, demanding efforts to minimize the non-diagnostic results in PTNB.

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“…CNLB-related complications mainly focus on pneumothorax, bleeding and/or a combination of both (25)(26)(27)(28)(29). The results showed that the incidence of complications in the experimental group was apparently lower than in the control group, though the findings did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 95%

Efficacy and safety of a new disposable percutaneous positioning device invented to facilitate the precision of percutaneous core needle lung biopsies: a prospective, open and randomized controlled study

Xu¹,

Fu²,

Cao³

et al. 2021

J Thorac Dis

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Background: A new disposable percutaneous positioning device was developed which permits adjustment of the fixing puncture angle while performing a percutaneous core needle lung biopsy (CNLB). The aim of the study was to explore the positioning accuracy and clinical safety of the new device during CT-guided percutaneous CNLB. Methods: A prospective, open and randomized controlled study with two parallel groups was conducted on 150 patients with pulmonary nodules between July 1, 2018 and June 30, 2019 including 101 males and 49 females who were divided (allocation ratio: 1:1) into a standard CNLB group without the percutaneous positioning device (control, n=75) and a new percutaneous positioning device group combined with CNLB (experimental, n=75). The efficacy was determined by the success rate of reaching the target location on the first percutaneous attempt, the number of CT scans performed and the time required for successful puncture positioning. Safety evaluations included complications related to percutaneous surgery and the new positioning device. Results: The success rate of reaching the target location on the first percutaneous attempt in the experimental group was significantly higher than in the control group [96.0% (72/75) vs. 42.7% (32/75), P<0.001]. Patients in the experimental group received 3.05±0.28 times CT scans on average for successful percutaneous positioning, which was significantly lower than for the control group (3.95±1.03) (P<0.001). The time required to complete the percutaneous positioning was significantly lower in the experimental group compared to the control group (8.73±3.11 vs. 12.79±4.55 min, P<0.001). There was no significant difference in percutaneous-related complications between the two groups [48.0% (36/75) vs. 61.3% (46/75), P=0.101], except that the bleeding rate in the experimental group was lower than in the control group [26.7% (20/75) vs. 46.7% (35/75), P=0.032]. Conclusions: The use of the optimized percutaneous technology with the new positioning device significantly improved the accuracy and precision of percutaneous lung biopsies.

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Immediate cytology improves accuracy and decreases complication rate in real‐time computed tomography‐guided needle lung biopsy

Cited by 11 publications

References 21 publications

Chinese multidisciplinary expert consensus: Guidelines on percutaneous transthoracic needle biopsy

Chinese multidisciplinary expert consensus: Guidelines on percutaneous transthoracic needle biopsy

Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Efficacy and safety of a new disposable percutaneous positioning device invented to facilitate the precision of percutaneous core needle lung biopsies: a prospective, open and randomized controlled study

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