Background and Purpose:To examine the respiratory and functional benefits of manual diaphragmatic release for Cleaning‐Laborers Exposed to Occupational Hazards.MethodsA randomized controlled trial of 36 participants aged 35–45 years was randomly allocated into two groups. The experimental group (n = 18); received manual diaphragm release along with respiratory training exercises, and the control group (n = 18); received respiratory training exercises only. Three times/week for 12 consecutive weeks. The serum immunoglobulin E level, pulmonary functions [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, and peak expiratory flow (PEF) rate (PEF)], chest wall mobility, and 6 min walk‐test performance were assessed pre‐ and post‐intervention.ResultsThere was a greater decline in serum immunoglobulin levels (p = 0.003; Partial η2 = 0.23) and enhancement in pulmonary functions [FEV1 (p = 0.025, Partial η2 = 0.14), FVC (p = 0.017, Partial η2 = 0.16), FEV1/FVC (p = 0.028, Partial η2 = 0.13), and PEF (p = 0.012, Partial η2 = 0.17) in the experimental group. Further, there was a greater increase in chest mobility at the xiphoid level (p = 0.002, Partial η2 = 0.25) in the experimental group, but this was not the case at the axillary level (p = 0.29, Partial η2 = 0.03). Still, the 6 min walk‐test performance improved more significantly in the experimental group (p = 0.002, Partial η2 = 0.24).ConclusionThe diaphragmatic release technique may offer a promising approach for mitigating distressing respiratory symptoms, enhancing immune function, and improving 6 min walk‐test performance among cleaning laborers with work‐related respiratory hazards.Trial registrationThe study was retrospectively registered at XXX (ID: NCT05802355).