Immediate Effects of tDCS on the μ-Opioid System of a Chronic Pain Patient

DosSantos, Marcos F.; Love, Tiffany M.; Martikainen, Ilkka K.; Nascimento, Thiago D.; Fregni, Felipe; Cummiford, Chelsea M.; DeBoer, Misty; Zubieta, Jon Kar; DaSilva, Alexandre F.

doi:10.3389/fpsyt.2012.00093

Cited by 95 publications

(110 citation statements)

References 36 publications

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“…Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique capable of modifying neuronal resting membrane potential and the level of spontaneous neuronal firing in the area of stimulation as well as in interconnected neural networks 1 including the endogenous μ-opioid system 2 , thereby modulating cortical excitability. The neuromodulatory effects of tDCS, combined with its low cost, simple application and portability, have led to its extensive use over the past decade in a wide variety of settings.…”

Section: Introductionmentioning

confidence: 99%

“…These have included neurophysiological studies, cognitive and behavioral interventions and patient studies assessing disorders such as chronic pain, depression, migraine, stroke, Parkinson's disease and tinnitus 3 . However, delivery of direct current (DC) is performed using large pads, most commonly between 25-35 cm 2 , which stimulate relatively broad areas of cerebral cortex located between the anode and cathode 4 . Therefore, focal stimulation of target cortical regions, not involving stimulation of neighboring anatomical areas, is difficult to achieve with this technique.…”

Section: Introductionmentioning

confidence: 99%

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Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Villamar

Volz

Bikson

et al. 2013

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191

155

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High-definition transcranial direct current stimulation (HD-tDCS) has recently been developed as a noninvasive brain stimulation approach that increases the accuracy of current delivery to the brain by using arrays of smaller "high-definition" electrodes, instead of the larger padelectrodes of conventional tDCS. Targeting is achieved by energizing electrodes placed in predetermined configurations. One of these is the 4x1-ring configuration. In this approach, a center ring electrode (anode or cathode) overlying the target cortical region is surrounded by four return electrodes, which help circumscribe the area of stimulation. Delivery of 4x1-ring HD-tDCS is capable of inducing significant neurophysiological and clinical effects in both healthy subjects and patients. Furthermore, its tolerability is supported by studies using intensities as high as 2.0 milliamperes for up to twenty minutes.Even though 4x1 HD-tDCS is simple to perform, correct electrode positioning is important in order to accurately stimulate target cortical regions and exert its neuromodulatory effects. The use of electrodes and hardware that have specifically been tested for HD-tDCS is critical for safety and tolerability. Given that most published studies on 4x1 HD-tDCS have targeted the primary motor cortex (M1), particularly for pain-related outcomes, the purpose of this article is to systematically describe its use for M1 stimulation, as well as the considerations to be taken for safe and effective stimulation. However, the methods outlined here can be adapted for other HD-tDCS configurations and cortical targets.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Villamar

Volz

Bikson

et al. 2013

JoVE

Self Cite

191

155

View full text Add to dashboard Cite

show abstract

“…The result showed the single active tDCS decreased μ-opioid receptor non-displaceable binding potential levels in (sub) cortical pain-matrix structures compared to sham tDCS, including nucleus accumbens, anterior cingulate cortex, insula, and especially in the posterior thalamus suggesting that the analgesic effect of M1-tDCS is possibly due to direct increase in endogenous opioid release. They also suggested that a single tDCS session may often have subclinical effects, but that repetitive sessions may be necessary to revert ingrained neuroplastic changes related to the chronic pain [36].…”

Section: Possible Mechanisms Of Actionmentioning

confidence: 99%

“…Finally, DosSantos et al identified μ-opioidergic effects of anodal tDCS by positron emission tomography (PET) [36]. They performed 2 mA anodal tDCS for 20 min in one trigeminal NP patient during PET scan using a μ-opioid receptor (μOR) selective radiotracer, [ 11 C] carfentanil.…”

Section: Possible Mechanisms Of Actionmentioning

confidence: 99%

Transcranial Direct Current Stimulation in Neuropathic Pain

Ngernyam¹

2014

J Pain Relief

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Neuropathic pain (NP) is one of the most common problems contributing to suffering and disability worldwide. Unfortunately, NP is also largely refractory to treatments, with a large number of patients continuing to report significant pain even when they are receiving recommended medications and physical therapy. Thus, there remains an urgent need for additional effective treatments. In recent years, nonpharmacologic brain stimulation techniques have emerged as potential therapeutic options. Many of these techniques and procedures -such as transcranial magnetic stimulation, spinal cord stimulation, deep brain stimulation, and motor cortical stimulation -have very limited availability, particularly in developing countries. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation procedure that has shown promise for effectively treating NP, and also has the potential to be widely available. This review describes tDCS and the tDCS procedures and principles that may be helpful for treating NP. The findings indicate that the analgesic benefits of tDCS can occur both during stimulation and beyond the time of stimulation. The mechanisms of cortical modulation by tDCS may involve various activities in neuronal networks such as increasing glutamine and glutamate under the stimulating electrode, effects on the μ-opioid receptor, and restoration of the defective intracortical inhibition. Additional research is needed to determine (1) the factors that may moderate the efficacy of tDCS, (2) the dose (e.g. number and frequency of treatment sessions) that results in the largest benefits and (3) the long-term effects of tDCS treatment.

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“…Transcranial direct current stimulation (tDCS) is a non-invasive technique that has emerged as a promising treatment for several pain syndromes [1][2][3] . This technique consists in the applying of a weak, direct, constant and low intensity electric current.…”

mentioning

confidence: 99%

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

Adachi¹,

Oliveira²,

Vercelino³

et al. 2017

Clin. Biomed. Res.

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Introduction: The transcranial direct current stimulation (tDCS) is a non-invasive technique, which induces neuroplastic changes in the central nervous system of animals and humans. Furthermore, tDCS has been suggested as a therapeutic tool for pain management. The aim of this study was to standardize a non-invasive tDCS technique indexed by the nociceptive response of rats submitted to different conditions necessary to the tDCS application.

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Immediate Effects of tDCS on the μ-Opioid System of a Chronic Pain Patient

Cited by 95 publications

References 36 publications

Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Transcranial Direct Current Stimulation in Neuropathic Pain

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

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