Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone: A case report and review of literature

Abstract

BACKGROUND In this case, platelet-rich fibrin (PRF) was added to guided tissue regeneration as a biomaterial in proper order for immediate planting in aesthetic area with periapical infection. CASE SUMMARY With the history of endodontic failure in maxillary central incisor, a 34-year-old female patient required the extraction of maxillary anterior residual root and immediate implantation. Cone beam computed tomography and clinical observation were used to assess the regeneration of soft and bone tissue. Before operation, cone beam computed tomography showed the anterior residual root had serious periapical periodontitis with insufficient labial bone in the aesthetic zone. The patient underwent immediate implant placement and reconstruction of the bone substitution by modified guided bone regeneration. The barrier was a three-layer structure of PRF-collagen membrane-PRF that covered the mixture of PRF and Bio-Oss to promote both osteogenesis and soft tissue healing. At 6 mo postoperatively, the definitive crown was placed after accomplished finial impression. One-year follow-up showed a satisfactory aesthetic effect with no obvious absorption of the labial bone and soft tissue. CONCLUSION The use of PRF in combination with guided bone regeneration can serve as a reliable and simple adjuvant for immediate implanting in infected socket and result in a stable osteogenic effect with good aesthetic outcome.

Effect of leukocyte‐platelet‐rich fibrin in bone healing around dental implants placed in conventional and wide osteotomy sites: A pre‐clinical study

“…Furthermore, the continued release of growth factors associated with L-PRF components, along with its densely polymerized structure, may have had a crucial role in hastening bone formation around the implant. 22,23 The use of L-PRF for gap management in immediate implant placement has been presented in several case reports [44][45][46][47][48] and clinical studies, [39][40][41][49][50][51] frequently in association with bone grafting materials. 52 However, only a handful of pre-clinical studies evaluating histologically the effect of L-PRF in this particular scenario have been reported in previous literature.…”

“…The use of L‐PRF for gap management in immediate implant placement has been presented in several case reports 44–48 and clinical studies, 39–41,49–51 frequently in association with bone grafting materials 52 . However, only a handful of pre‐clinical studies evaluating histologically the effect of L‐PRF in this particular scenario have been reported in previous literature 42,53,54 .…”

Major aproaches of the use of FRP and Bio-Oss® in bone regeneration and elevation for implantology: a concise systematic review

“…In this context, implant dentistry stands out as a modern method of oral rehabilitation for totally or partially edentulous patients. For this method to properly, bone integration of the implant into the recipient bone tissue must occur, since bone integration is the key to clinical surgical success, which will be completed after the end of the prosthetic phase [14]. Dental implants are being used more and more due to the high success rates.…”

Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells

“…Osteoblasts are a highly specialized cell type and seem to tolerate contact with inorganic surfaces better than undifferentiated cells. The current trend in research is to improve well-known dental materials by focusing on their physicochemical properties or adding growth factors and cells for augmentation [ 28 , 44 , 45 ]. A recent study successfully combined BO with concentrated growth factor gel for regeneration of cranial defect models in vivo.…”