Immediate injection pain in infants aged 18 months during vaccination against measles, mumps and rubella with either Priorix® or MMR-II®

Knutsson, Nina; Jansson, Ulla-Britt; Alm, Bernt

doi:10.1016/j.vaccine.2006.05.004

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…Four RCTs [33][34][35][36] including 1027 children (12 months to 6 years of age) each compared two brands of measles-mumpsrubella vaccine: Priorix (SmithKline Beecham Pharma, Glaxo SmithKline) and M-M-R-II (Merck Frosst Canada & Company) or RORVax (Aventis Pasteur-MSD), the equivalent of M-M-R-II. All of the studies reported less pain among children who received the Priorix brand.…”

Section: Brand Of Vaccinementioning

confidence: 99%

Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline

Taddio¹,

Appleton²,

Bortolussi³

et al. 2010

Canadian Medical Association Journal

198

199

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Section: Brand Of Vaccinementioning

confidence: 99%

Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline

Taddio¹,

Appleton²,

Bortolussi³

et al. 2010

Canadian Medical Association Journal

198

199

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“…In the light of findings concerning the effects of parental anxiety on their infant's pain experience (e.g. Guerra, 2007;Knutsson, Jansson, & Alm, 2006) we investigated whether parity might influence the expression of infant distress. Furthermore, given the results of previous studies (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effects of maternal parity, depression and stress on two-month-old infant expression of pain

Reissland

Harvey

Mason

2012

Journal of Reproductive and Infant Psychology

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Objective: This study investigates effects of maternal parity, mental health and frequency of touch on infant distress expressed during routine vaccination, as well as the ability of mothers to assess infant pain. Methods: 50 mothers (19 first-time mothers, 23 stressed, 8 depressed) and their 2-month-old infants (mean age 8.1 weeks, range 7-9 weeks) were videotaped during routine immunisation for off-line-analysis. Infant-related pain behaviours were coded before, during and after needle insertion. Maternal touch was coded throughout the immunisation procedure and maternal estimates of infant pain were established immediately after the procedure. Results: Infants of first-time mothers showed significantly more pain before the needle insertion as well as during the first vaccination, compared with infants of experienced mothers. In contrast to expectation, maternal mental health status and type of touch did not influence the level of pain expressed by infants. Mothers consistently overestimated infant pain and their assessments were poorly correlated with observed infant pain behaviours. Conclusion: These findings suggest that maternal parity may influence infant pain expression before vaccination. However, all mothers overestimate their infant's pain. Further studies are required to resolve conflicting findings in this field of research, as findings may have policy implications in promoting adherence to the vaccination schedule.

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“…46 Likewise, the brand of the vaccine can influence pain based on the pH of the contents. [47][48][49][50] Vaccines that are less acidic are effective in lowering vaccination pain and can be easily combined with other interventions.…”

Section: Vaccine Phmentioning

confidence: 99%

“…46 Three studies investigated the vaccination Priorix as compared with the Measles, Mumps, and Rubella Vaccine (MMRII). [47][48][49] In all three of these studies, post-injection pain was significantly reduced with the use of Priorix versus MMRII brand of measles, mumps, and rubella (MMR) vaccination (P,0.008-0.001). Priorix has a pH of approximately 7.2, whereas MMRII has a pH of approximately 6.2.…”

mentioning

confidence: 99%

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Minimizing pain during childhood vaccination injections: improving adherence to vaccination schedules

Eden¹,

Macintosh²,

Luthy³

et al. 2014

PHMT

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Pain experienced in childhood can lead to long-term and psychologically detrimental effects. Unfortunately, the most common pain experienced in childhood is caused by vaccinations and may lead to non-adherence to the recommended vaccination schedule. As a result, it is the health care provider's responsibility to take measures to reduce vaccination pain; however, there are a plethora of pain relieving interventions during immunizations and it is unclear which interventions are most cost efficient, timely, and effective. Studies have been conducted to investigate the efficacy of different pain management interventions during vaccinations. This review evaluates various pain relieving interventions and provide health care providers age appropriate guidance on pain relieving interventions during vaccinations. Employment of these strategies may successfully reduce vaccination-associated pain in infants, children, and adolescents, and may improve compliance with the vaccination schedule.

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Immediate injection pain in infants aged 18 months during vaccination against measles, mumps and rubella with either Priorix® or MMR-II®

Cited by 12 publications

References 19 publications

Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline

Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline

Effects of maternal parity, depression and stress on two-month-old infant expression of pain

Minimizing pain during childhood vaccination injections: improving adherence to vaccination schedules

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