Purpose-The purpose of this study was to estimate one-year implant survival for delayed versus immediately loaded implants and identify risk factors for implant failure.Materials and Methods-This was a retrospective cohort study, consisting of a sample of subjects who had ≥ 1 Bicon® dental implant placed over a 13-year period. The primary predictor variable was method of implant loading: delayed (3 -6 months after placement) or immediately after insertion. Secondary predictor variables were classified as demographic, anatomic, implant/ abutment and reconstructive. The outcome variable was implant failure, defined as removal of the implant and was recorded as months of survival. Descriptive, Kaplan-Meier, and univariate Cox proportional hazards statistics were computed. Univariate associations with p ≤ 0.15 and biologically relevant variables (e.g. age, gender) were included in a marginal multiple Cox regression model. In the multiple model, a p-value ≤ 0.05 was considered statistically significant.Results-The study sample consisted of 677 subjects who had 2349 delayed loaded dental implants and 178 patients who had 477 immediate loaded implants. The unadjusted one-year survival estimates for the delayed and immediate loading groups were 95.5% and 90.3%, respectively (p < 0.01). In the marginal multiple Cox regression model, immediate loading, current tobacco use, maxillary implants, and shorter implants were associated with failure (p ≤ 0.05).Conclusion-In this study, immediately loaded implants were 2.7 times (after adjusting) more likely to fail at one-year compared to delayed loaded implants.