Immediate Mandibular Reconstruction of a 5 cm Defect Using rhBMP‐2 After Partial Mandibulectomy in a Dog

Abstract

Immediate reconstruction of large mandibular defects with osteoinductive materials as a graft substitute may be a viable alternative to partial mandibular resection or radiation therapy for benign odontogenic tumors in dogs.

Tissue-Engineered Mandibular Bone Reconstruction for Continuity Defects: A Systematic Approach to the Literature

“…In line with these results are the reported effects of rhBMP-2 15,31,32,98,99,103,110 and rhBMP-7 33 for mandibular bone regeneration in continuity defects. On the other hand, it should be mentioned that rhBMP-2, in the reports of Zhou et al 109 and Seto et al, 102 as well as rhBMP-7, in the paper of Ayoub et al, 17 have not always been associated with bony union.…”

“…Furthermore, in total, 15 scientific papers 15,18,29,31,32,[97][98][99][101][102][103]105,106,109,110 reporting on recombinant human bone morphogenetic protein-2 (rhBMP-2) as well as five publications 16,17,19,30,33 presenting data on recombinant human bone morphogenetic protein-7 (rhBMP-7) were eventually included in the current systematic approach. Thereby, the brief summarized studies of Kontaxis et al, 16 Abu-Serriah et al, 19 Boyne, 29,101 Busuttil Naudi et al, 30 and Toriumi et al 97 may give a good general impression of the effectiveness of rhBMPs regarding the quantity as well as quality of induced bone for the reconstruction of continuity mandibular defects (Details can be found in Addendum No.…”

“…In summary, rhBMP-2 and rhBMP-7 were studied in combination with collagen/collagen composite scaffolds, [15][16][17][18][19]29,32,33,99,101,108,110 poly-D,L-lactide coglycolic acid based carriers. 31 102 and a bovine collagen type I carrier wrapped into a sterno-occipitalis muscle flap 17 were not associated with predictable defect bridging.…”

“…Furthermore, these scaffolds should possess (3) suitable surface chemistry for cell attachment, proliferation, and differentiation, and (4) mechanical properties to match those of the tissues at the site of implantation. 9 At present, a multitude of scaffolds made of various material [10][11][12][13][14][15][16][17][18][19] in combination with bioactive substances or osteogenic bone marrow stromal cells (BMSCs) 10,[20][21][22][23][24][25][26] to initiate or enhance bone formation [15][16][17]19,[27][28][29][30][31][32][33] are under study. In 2006, Ikada defined a concept on methodology in tissue engineering as (1) placing the construct scaffold in a bioreactor to reconstruct an engineered tissue in vitro called in vitro (or ex vivo) tissue engineering and (2) implantation of the construct scaffold in the body until a new tissue is regenerated in vivo called in vivo (or in situ) tissue engineering.…”

Mandibular cystic defect: A composite approach with rhBMP-2 and rib graft

“…The jaws were stabilized with bone plates or titanium mesh and treated with rhBMP-2 combined with freeze dried demineralized or mineralized particulate bone [13]. Veterinary literature reports of cases where large mandibular defect has been reconstructed using rhBMP-2 with plates holding mandible in position [14].…”