Immediate postoperative thrombocytopenia following elective abdominal aortic anuerysm repair and aortic vascular surgery for occlusive disease

Satchidanand, Rajesh Y.; Nandhara, G; Chowdary, Pratap; Woodyer, Anthony

doi:10.1055/s-0031-1276342

Cited by 1 publication

(1 citation statement)

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“…Surgery results in complement activation, neutrophil degranulation, and release of pro-inflammatory cytokines such as IL-6 and tumor necrosis factor-α (TNF-α), which cause endothelial cell dysfunction and release of tissue factor and von Willibrand (vWB) factor leading to platelet activation, aggregation, and consumption [ 22 ]. Physiologic postoperative thrombocytopenia is usually mild, not associated with clinical bleeding, and resolves spontaneously in three to four days [ 23 ]. If there is persistence of thrombocytopenia beyond five days or the onset is late (> 5 days), other causes should be considered.…”

Section: Postoperative Thrombocytopeniamentioning

confidence: 99%

New-onset acute thrombocytopenia in hospitalized patients: pathophysiology and diagnostic approach

Ali

Auerbach

2017

Journal of Community Hospital Internal Medicine Perspectives

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Thrombocytopenia is a hematological finding commonly encountered in daily clinical practice from asymptomatic clinic patients to critically ill intensive care unit patients. A broad spectrum of etiologies and variation in clinical presentation often present a diagnostic challenge. Furthermore, concomitant presence of thrombosis and thrombocytopenia, as in cases of thrombotic thrombocytopenia, complicates the management. In hospitalized patients, new-onset thrombocytopenia is an important reason for hematology consultation. Therefore, it is of utmost importance that the etiology is diagnosed accurately. In addition, a basic understanding of the pathophysiology and the differential diagnosis avoids delay in the diagnosis and leads to rapid initiation of treatment. This review will address causes of thrombocytopenia that arises in hospitalized patients with an emphasis on the pathophysiological basis of each disorder.

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Section: Postoperative Thrombocytopeniamentioning

confidence: 99%