Immediate protection of swine from foot-and-mouth disease: a combination of adenoviruses expressing interferon alpha and a foot-and-mouth disease virus subunit vaccine

Moraes, Mauro Pires; Chinsangaram, Jarasvech; Brum, Mário Celso Sperotto; Grubman, Marvin J.

doi:10.1016/s0264-410x(03)00560-7

Cited by 107 publications

(92 citation statements)

References 37 publications

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“…Thus far, we have demonstrated that inoculation of mice with VRP-GFP induced a strong protective antiviral response against FMDV which correlated with increased levels of IFN-␣ in serum. This is in accordance with the demonstrated antiviral and protective effect of type I IFN against FMDV in the natural host (4,9,10). To confirm the antiviral effect of IFN-␣ against FMDV in the mouse model, we treated groups of five mice with 10 4 U of muIFN-␣ followed by challenge with 5 ϫ 10 4 PFU of FMDV A24 at 4 or 18 h after treatment.…”

Section: Ib-rs-2 Cells Do Not Respond To Vrp-gfp Infectionsupporting

confidence: 79%

“…We have previously demonstrated that swine inoculated with Ad5-poIFN-␣ are rapidly protected when challenged 1 day later with FMDV (4,9,10). More recently we also showed that treatment of bovines with Ad5-boIFN-3 can significantly delay and reduce clinical disease (12).…”

Section: Discussionmentioning

confidence: 93%

“…Antiviral activity was evaluated in supernatants as previously described (4). Samples were diluted and incubated on IB-RS-2 cells for approximately 24 h. Supernatants were removed, and the cells were infected for 1 h with approximately 100 PFU of FMDV serotype A12 and overlaid with gum tragacanth.…”

Section: Cells and Virusesmentioning

confidence: 99%

“…Administration of the inactivated vaccine or an experimental vaccine based on a replication-defective human adenovirus 5 (Ad5) vector containing the FMDV capsid and 3C proteinase coding regions requires approximately 7 days to induce protective immunity in animals (3)(4)(5). As a result, vaccinated animals exposed to virus within the first 7 days after vaccination are still susceptible to the disease.…”

mentioning

confidence: 99%

“…We have shown that FMDV replication is inhibited by prior treatment of cells with interferon type I (IFN-␣/␤), II, or III (6)(7)(8). Based on this information, we constructed Ad5 vectors containing porcine type I IFN genes (Ad5-poIFN-␣/␤) and demonstrated that swine inoculated with Ad5-poIFN-␣/␤ are protected from challenge with FMDV A24 Cruzeiro as early as 1 day after Ad5-poIFN-␣/␤ administration (4,9,10). Protection can last for 3 to 5 days (4).…”

mentioning

confidence: 99%

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Venezuelan Equine Encephalitis Replicon Particles Can Induce Rapid Protection against Foot-and-Mouth Disease Virus

Segundo

Dias

Moraes

et al. 2013

J Virol

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Section: Ib-rs-2 Cells Do Not Respond To Vrp-gfp Infectionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 93%

Section: Cells and Virusesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Venezuelan Equine Encephalitis Replicon Particles Can Induce Rapid Protection against Foot-and-Mouth Disease Virus

Segundo

Dias

Moraes

et al. 2013

J Virol

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Foreign Animal Diseases and Food System Security: Decision Making for Appropriate Responses

Slenning

Tickel

2008

Wiley Handbook of Science and Technology for Homeland Security

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Foreign animal diseases (FADs), such as highly pathogenic avian influenza or foot and mouth disease (FMD; a worst‐case FAD), are documented threats, whether through accidental or intentional exposures. US policies, as with most countries where an FAD is not endemic, follow ‘Stamping Out/Eradication’ (SOE) protocols if it is found: Affected herds are rapidly destroyed to eradicate the agent and quickly resume export trade. While historically effective in eradicating disease, SOE goals and techniques no longer represent a sole source solution to disease events affecting western agriculture. For instance, [1] their focus on international trade is inappropriate; [2] their assumptions on the nature of such outbreaks are incorrect; [3] new technologies are not included; and [4] their unintended consequences are huge. These errors can result in responses that, in modern concentrated agricultural markets, may cause such damage that markets will not recover. In short, in our drive to protect agriculture, we may actually destroy it. A factor missing from most FAD planning is an in‐depth consideration of how agriculture will cope during an outbreak and how it will recover (e.g. business continuity). We must re‐evaluate plans to ensure that the event and all its consequences are managed as opposed to blindly eradicating a disease agent at great cost. By addressing the true threats FADs pose to today's agriculture, we will lessen the effects of natural or accidental FAD outbreaks, and will make FADs less attractive as bioterror tools.

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Generation of Replication Deficient Human Adenovirus 5 (Ad5) Vectored FMD Vaccines

Medina

Santos

Segundo

2022

Methods in Molecular Biology

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Immediate protection of swine from foot-and-mouth disease: a combination of adenoviruses expressing interferon alpha and a foot-and-mouth disease virus subunit vaccine

Cited by 107 publications

References 37 publications

Venezuelan Equine Encephalitis Replicon Particles Can Induce Rapid Protection against Foot-and-Mouth Disease Virus

Venezuelan Equine Encephalitis Replicon Particles Can Induce Rapid Protection against Foot-and-Mouth Disease Virus

Foreign Animal Diseases and Food System Security: Decision Making for Appropriate Responses

Generation of Replication Deficient Human Adenovirus 5 (Ad5) Vectored FMD Vaccines

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