Immediate re-resection of T1 incidental gallbladder carcinomas: a survival analysis of the German Registry

Goetze, Thorsten Oliver; Paolucci, V.

doi:10.1007/s00464-008-9747-9

Cited by 89 publications

(63 citation statements)

References 23 publications

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“…5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] All the studies were non-randomized control trials. Table 1 and 2 respectively show the character of included literatures and NOS quality assessment scale.…”

Section: Characteristics Of Included Literatures and Quality Assessmentmentioning

confidence: 99%

“…5,[11][12][13][14][16][17][18][19]21,23,24 Data of 1-year survival rate from nine studies can be pooled (Figure 2). Heterogeneity exists (χ2 = 11.54, P = 0.17, I2 = 31%), hence random model was used, and the result shows RR is obviously better than SC in increasing 1-year survival rate (OR=3.28, 95% CI: 1.83-5.89, P<0.0001).…”

Section: Survival Rate Analysismentioning

confidence: 99%

“…Tis and T1a stage GBC has an encouraging probability of getting radical cure by simply cholecystectomy, and patients with these stages of GBC may not benefit from a radical resection. 5 But it is noteworthy that gallbladder rupturing or bile leaking during the cholecystectomy may bring about tumor cells metastasis, for cases like these, a re-resection shall be taken into consideration. 6 Unlike the consensus on T1a GBC, whether T1b GBC needs radical resection is still controversial.…”

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confidence: 99%

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Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

Cheng

Qiu

et al. 2017

Int Surg J

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INTRODUCTIONGBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. 1 It still relies on surgical method to treat and provide the possibilities of favorable prognosis, while auxiliary methods like radiotherapy and chemotherapy are likely to reduce the chance of tumor relapse and improve the longterm survival of GBC patients. 2 GBC patients' survival time -one of the major indicators for prognosis judgment isn't affected by sexuality, age or ABSTRACT Background: GBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. The objective of this study was to evaluate the importance of radical resection in the treatment of Nevin II and T1b stage gallbladder cancer (stage II GBC) by analyzing the survival rate and tumor recurrence rate after accepting simple cholecystectomy (SC) and radical resection (RR). Methods: PubMed, Embase, Chinese National Knowledge Infrastructure and Wanfang databases was searched from inception to February 2016. Quality assessment was conducted in each of the available studies by using the validated Newcastle-Ottawa Quality Assessment Scale (NOS) for cohort and case-control studies. Publication bias was also assessed by using a funnel plot. The odds ratio (OR) and its 95% confidence interval (95% CI) were employed to estimated effect size. All statistical analyses were carried out using Rev Man 5.2 software. Results: A total of fifteen studies encompassing 424 patients meeting the search criteria were included. Pooled analyses revealed that comparing to simple cholecystectomy, radical resection can significantly increase the 1-, 3-and 5-year survival rate of patients with stage II GBC (OR = 3.28, 95% CI: 1.83-5.89, P<0.0001; OR = 2.52, 95% CI: 1. P = 0.0006; OR = 3.19, P<0.0001), and patients after radical resection have a significant lower tumor recurrence rate (OR = 0.30, 95% CI: 0.11-0.80, P = 0.02). Conclusions:The short-and long-term survival rate of patients with stage II GBC following radical resection is obviously higher than that of patients receiving simple cholecystectomy, and the tumor recurrence rate is obviously lower. Radical resection would be a better choice for stage II GBC.

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Section: Characteristics Of Included Literatures and Quality Assessmentmentioning

confidence: 99%

Section: Survival Rate Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

Cheng

Qiu

et al. 2017

Int Surg J

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“…Dear Editor, I enjoyed reading the article about incidental gallbladder cancers and the role of re-resection [1]. Recently, I was called by a pathologist and informed that a gallbladder specimen with a large polyp was consistent with a gallbladder cancer-a T1 lesion.…”

mentioning

confidence: 99%

“…Now, we purposely do this and it seems to be accomplished without regard-until the specimen comes back with gallbladder cancer. The previous article cited that gallbladder cancer is found in only 0.2-2.9% of cholecystectomies and that incidental findings are found in 0.5-1% of laparoscopies [1,2]. This is an exciting time in minimally invasive surgery because the keen mind can be free to imagine and implement more slick and consumer-friendly approaches to the world of surgery.…”

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confidence: 99%