Abstract:Background: Leukoaraiosis (LA) affects cognition after stroke and reversal of LA may improve cognitive performance. We aimed to determine the impact of cerebral perfusion and circle of Willis (CoW) flow patterns on the extent of LA after carotid artery revascularization. Methods: LA was scored on fluid-attenuated inversion recovery magnetic resonance (MR) images at the levels of the centrum semiovale and frontal horns in both cerebral hemispheres of 62 contiguous patients (men/women = 38/24, mean age = 63.2 ± … Show more
“…However, the correlation of leukoaraiosis with cerebral atherosclerosis is not ascertained, and conflicting conclusions have been reported. [16][17]19,21 In our study, we did not find the association between the severe carotid atherosclerosis and WMLs in periventricular and deep white matter. The results supported that WMLs are not correlated with atherosclerosis and may be one type of small-vessel disease.…”
Section: Discussioncontrasting
confidence: 72%
“…5,19,20 Recent study even indicated that carotid artery revascularization could reduce the severity of leukoaraiosis. 21 Chronic cerebral hypoperfusion due to arterial stenosis may be the underlying mechanism of WMLs. It also could induce the collateralization.…”
“…However, the correlation of leukoaraiosis with cerebral atherosclerosis is not ascertained, and conflicting conclusions have been reported. [16][17]19,21 In our study, we did not find the association between the severe carotid atherosclerosis and WMLs in periventricular and deep white matter. The results supported that WMLs are not correlated with atherosclerosis and may be one type of small-vessel disease.…”
Section: Discussioncontrasting
confidence: 72%
“…5,19,20 Recent study even indicated that carotid artery revascularization could reduce the severity of leukoaraiosis. 21 Chronic cerebral hypoperfusion due to arterial stenosis may be the underlying mechanism of WMLs. It also could induce the collateralization.…”
“…Restoration of cerebral perfusion by carotid revascularization can reduce the severity of leukoaraiosis [18]. Although the OA flow direction is sensitive to the overall cerebral perfusion condition, whether the reconstitution of cerebral perfusion through reversed OA flow is adequate to maintain cognitive function or can be employed as a surrogate marker of cognitive impairment remains elusive.…”
“…Когнитивная послеоперационная дисфункция -од-на из серьезнейших проблем современной реабилитации пациентов после кардиохирургических и сосудистых опе-раци й во всем мире [4,[7][8][9][10]. Операции на дуге аорты (ДА) выполняют по жизненным показаниям при абсо-лютной бесперспективности консервативного лечения, в то время как хирургия брахицефальных артерий (БА) при-звана сократить частоту фатального и грубого очагового поражения центральной нервной системы (ЦНС).…”
unclassified
“…Y. Chuang и соавт. [10] с по-мощью МРТ и ангиографии сравнили размеры зон лейко-ареоза у 62 пациентов, перенесших инсульт ГМ, до стен-тирования и в ближайшем послеоперационном периоде. Авторы выявили зависимость замкнутости виллизиева круга на факт развития инсульта у пациентов с унилате-ральным стенозом внутренней сонной артерии, а также продемонстрировали, что уменьшение старых зон лейко-ареоза происходит сразу после операции.…”
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