Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

Yu, Deng‐Guang; Zheng, X. L.; Yang, Yaoyao; Li, Xiao Yan; Williams, Gareth R.; Zhao, Min

doi:10.1016/j.apsusc.2018.12.147

Cited by 49 publications

(34 citation statements)

References 54 publications

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“…Different arrays have been used by electrospraying for the formation of nanoparticles as coaxial electrospraying for core‐shell nanoparticles (Wang, Wen, Yu, Yang, & Zhang, ; Yang, Zhang, Wang, & Yu, ; Yu et al., ), coaxial electrospraying to creating high‐quality monolithic particles (Li et al., ; Liu et al., ; Yang, Zhang, Liu, Wang, & Yu, ), and to study the influences of experimental parameters and process characteristics on working processes (Huang et al., ). However, few publications can be found to investigate the relationships between the working fluids’ properties and their adaptability for electrospraying, which is a significant merit of the present work.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Quercetin is a hydrophobic flavonoid with high antioxidant activity. However, for biological applications, the bioavailability of quercetin is low due to physiological barriers. For this reason, an alternative is the protection of quercetin in matrices of biopolymers as zein. The objective of this work was to prepare and characterize quercetin‐loaded zein nanoparticles by electrospraying and its study of in vitro bioavailability. The physicochemical parameters such as viscosity, density, and electrical conductivity of zein solutions showed a dependence of the ethanol concentration. In addition, rheological parameters demonstrated that solutions of zein in aqueous ethanol present Newtonian behavior, rebounding in the formation of nanoparticles by electrospraying, providing spherical, homogeneous, and compact morphologies, mainly at a concentration of 80% (v/v) of ethanol and of 5% (w/v) of zein. The size and shape of quercetin‐loaded zein nanoparticles were studied by transmission electron microscopy (TEM), observing that it was entrapped, distributed throughout the nanoparticle of zein. Analysis by Fourier transform‐infrared (FT‐IR) of zein nanoparticles loaded with quercetin revealed interactions via hydrogen bonds. The efficacy of zein nanoparticles to entrap quercetin was particularly high for all quercetin concentration evaluated in this work (87.9 ± 1.5% to 93.0 ± 2.6%). The in vitro gastrointestinal release of trapped quercetin after 240 min was 79.1%, while that for free quercetin was 99.2%. The in vitro bioavailability was higher for trapped quercetin (5.9%) compared to free quercetin (1.9%), than of gastrointestinal digestion. It is concluded, that the electrospraying technique made possible the obtention of quercitin‐loaded zein nanoparticles increasing their bioavailability. Practical Application This type of nanosystems can be used in the food and pharmaceutical industry. Quercetin‐loaded zein nanoparticles for its improvement compared to free quercetin can be used to decrease the prevalence of chronic degenerative diseases by increasing of the bioavailability of quercetin in the bloodstream. Other application can be as an antioxidant system in functional foods or oils to increase shelf life.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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“…Although EHDA processes (including e‐jet printing, electrospraying, and electrospinning) are fast developing to the multiple‐fluids ones, such as coaxial (Hai et al., ; Yu et al., ), triaxial (Liu et al., ; Yang et al., ), their microformation mechanisms are still unclear (Yang, Zhang, Liu, Wang, & Yu, ; Yu, Li, Williams, & Zhao, ). Thus, on one hand, the single‐fluid electrospraying and electrospinning are still the mainstreams of these fabrication methods.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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“…Similarly, as a peer advanced technology of electrospinning, electrospraying can be useful for teaching materials to dispel learning doubts for the college students majoring in Material Science and Engineering. Electrospraying, a straightforward process for generating micro-/nano-particles in a single-step manner, is also a "top-down" nanofabrication technology that takes advantage of the interactions between the working fluids and the high voltage electrostatic energy [19][20][21][22]. Fig.…”

Section: B the Applications Of Electrospraying In Dispelling Doubts mentioning

confidence: 99%

The Applications of Advanced Technologies in Dispelling Students Doubts’ about Their Majors

Wang¹,

Pu²,

Guan³

et al. 2019

Proceedings of the 2019 5th International Conference on Social Science and Higher Education (ICSSHE 2019)

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In China, many college students don't know their majors well during choosing them after their successful college entrance examinations. When they go into the college and begin their specialty learning, they are often puzzled by a series of doubts about their discipline knowledge. How to help them to dispel those doubts is very important for them to become senior professional talents in the future. In this paper, an approach is put forward as an alternative method for eliminating the college students' learning doubts about their major. Based on two advanced technologies (electrospinning and electrospraying), some positive teaching materials are refined to dispel the students' doubts and meanwhile increasing their interests about the professional knowledge for those majoring in the specialty of Material Science and Engineering. The strategies exhibited here should be similarly useful for college students majoring in other disciplines.

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Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

Cited by 49 publications

References 54 publications

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

The Applications of Advanced Technologies in Dispelling Students Doubts’ about Their Majors

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