Immediate Remission Obtained by Minocycline in a Patient with Histiocytic Necrotizing Lymphadenitis.

Abstract

A 29-year-old man was admitted because of fever, arthralgia and swelling of the cervical lymph nodes. A diagnosis of histiocytic necrotizing lymphadenitis (HNL) was madebased on the findings of a lymph node biopsy. At first, piperacillin sodium (PIPC) was started, but a spiking fever persisted. Wetherefore changed the PIPC treatment to minocycline. On the following day, his clinical and laboratory findings were dramatically improved. After administering minocycline for 10 days, the HNLsymptoms completely disappeared. He has been in good health for 3 years since undergoing treatment. This case strongly indicates that minocycline-sensitive microorganism(s) maybe related, at least in part, to the etiology of HNL.

The Enigmatic Kikuchi-Fujimoto Disease: A Case Report and Review

“…In case of extranodal disease with neurological involvement, the use of corticosteroids appears to improve the patient's condition rapidly. Use of hydroxychloroquine [17, 18], immunoglobulins [19], and minocycline [20] has been reported with excellent results in some cases [7]. …”

Kikuchi-Fujimoto Disease: A Case Report and Literature Review

“…A high initial oral dose of prednisolone with a subsequent reducing dose is the advocated regime [45, 46]. There are reports of excellent responses to hydroxychloroquine [47, 48], immunoglobulins [49], and minocycline [50]. Recurrence of KFD is approximately 3% [3].…”

Kikuchi-Fujimoto disease

“…Takada ve ark. [10] minosiklin ile tedavi ettikleri bir hastada hastalık belirtilerinin gerilediğini tespit ettikten sonra, Kikuchi-Fujimoto hastalığına minosikline duyarlı bir enfeksiyöz ajanın yol açtığını öne sür-müşlerdir.…”