Immediate risk of non-cancer deaths after a cancer diagnosis

Yang, Pengcheng; Zheng, Yongqiang; Chen, Jiayuan; Ma, Haotian; Yu, Kaixu; Chen, Ying; Yang, Yan; Wu, Bian

doi:10.1186/s12885-021-08707-6

Cited by 14 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed that MPCs patients are perpetually at elevated risk of death from CVD compared to the general population, as well as comparison with SPC patients. Consistent with previous reports, younger age of diagnosis is associated with higher SMR ( 29 ), and the first year of cancer diagnosis represents the period with extended risks for both SMR and mortality rate of CVD ( 30 , 31 ). These findings might also be partially explained by the negative psychological stress, as well as the aggressive treatment shortly after cancer discovery and long-time at risk until the death of the general population ( 32 , 33 ).…”

Section: Discussionsupporting

confidence: 90%

Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States

Wang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundPrevious studies have demonstrated that patients with a cancer diagnosis have an elevated risk of suicide and cardiovascular death. However, the effects of the diagnosis of multiple primary cancers (MPCs) on the risk of suicide and cardiovascular death remain unclear. This study aimed to identify the risk of suicide and cardiovascular death among patients with MPCs in the United States.MethodsPatients with a single or MPC(s) between 1975 and 2016 were selected from the Surveillance, Epidemiology, and End Results database in a retrospective cohort study. Mortality rates and standardized mortality ratios (SMRs) of suicides and cardiovascular diseases among patients with MPCs were estimated.ResultsOf the 645,818 patients diagnosed with MPCs included in this analysis, 760 and 36,209 deaths from suicides and cardiovascular diseases were observed, respectively. The suicide and cardiovascular-disease mortality rates were 1.89- (95% CI, 1.76–2.02) and 1.65-times (95% CI, 1.63–1.67), respectively, that of the general population. The cumulative mortality rate from both suicides and cardiovascular diseases among patients with MPCs were significantly higher than those of patients with a single primary cancer (Both p < 0.001). In patients with MPCs diagnosed asynchronously, the cumulative incidence rates of suicides and cardiovascular deaths were higher than those diagnosed synchronously. Among all MPCs, cancers of the pancreas and esophagus had the highest SMRs of suicide (5.98 and 5.67, respectively), while acute myeloid leukemia and brain cancer had the highest SMRs of cardiovascular diseases (3.87 and 3.62, respectively). The SMR of suicide was highest within 1 year after diagnosis, while that of cardiovascular diseases was highest 5 years after diagnosis.ConclusionsThis study showed that the mortality rates from suicides and cardiovascular diseases among patients with MPCs were higher than those with a single primary cancer. Therefore, our results underscore the need for psychological assessment and targeted preventive interventions for suicides and cardiovascular diseases among patients with MPCs.

show abstract

Section: Discussionsupporting

confidence: 90%

Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States

Wang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…This emphasized the importance of uncovering the detailed causes of death in these long-term malignancy patients, as a cancer history will meaningfully alter the distribution of causes of death among these individuals and will inform interventions with respect to mitigating mortality risk and promoting survivorship and quality of life ( 7 , 8 , 31 , 32 ). Our work, as well as that of prior studies, shows that cancer and its treatments may increase the short- and long-term risks of non-cancer death ( 7 , 15 ).…”

Section: Discussionsupporting

confidence: 74%

“…In addition, the risk of non-cancer comorbidities is increased as a consequence of the malignancy itself as well as the treatments administered. For example, an increased risk of non-cancer death immediately after cancer diagnosis has been reported ( 15 ). Although a few studies have evaluated the causes of death amongst patients with thyroid carcinoma (including Korea and Taiwan), the range of causes of death evaluated in these studies was much less comprehensive than in the current study and the sample sizes were small ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Cause of Death Among Patients With Thyroid Cancer: A Population-Based Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

BackgroundOver the last decades, the number of patients diagnosed with thyroid carcinoma has been increasing, highlighting the importance of comprehensively evaluating causes of death among these patients. This study aimed to comprehensively characterize the risk of death and causes of death in patients with thyroid carcinoma.MethodsA total of 183,641 patients diagnosed with an index thyroid tumor were identified from the Surveillance, Epidemiology, and End Result database (1975–2016). Standardized mortality rates (SMRs) for non-cancer deaths were calculated to evaluate mortality risk and to compare mortality risks with the cancer-free US population. Cumulative mortality rates were calculated to explore the factors associated with higher risk of deaths.ResultsThere were 22,386 deaths recorded during follow-up, of which only 31.0% were due to thyroid cancer and 46.4% due to non-cancer causes. Non-cancer mortality risk among patients with thyroid cancer was nearly 1.6-fold (SMR=1.59) that of the general population. Cardiovascular diseases were the leading cause of non-cancer deaths, accounting for 21.3% of all deaths in thyroid cancer patients. Non-cancer causes were the dominant cause of death in thyroid cancer survivors as of the third year post-diagnosis. We found that males with thyroid cancer had a higher risk of all-cause mortality compared with females. The risk of suicide was highest in the first post-diagnostic year (<1 year: SMR=1.51). The long-term risk of Alzheimer’s disease was notably increased in thyroid cancer patients (>5 years: SMR=8.27).ConclusionNon-cancer comorbidities have become the major risks of death in patients with thyroid tumor in the US, as opposed to death from the tumor itself. Clinicians and researchers should be aware of these risk trends in order to conduct timely intervention strategies.

show abstract

“… 2 , 3 , 4 , 5 , 6 Such distress also increases the mortality rate due to other externally caused injuries (ECIs) in them, 7 which may sometimes be a suicide misclassification. 8 , 9 Patients with cancer also have a high risk of death from cardiovascular disease, 2 , 10 , 11 , 12 , 13 seemingly due to several factors, including psychological distress. 2 , 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 Patients with cancer also have a high risk of death from cardiovascular disease, 2 , 10 , 11 , 12 , 13 seemingly due to several factors, including psychological distress. 2 , 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population‐based study in Japan (J‐SUPPORT 1902)

Kurisu

Fujimori²,

Harashima

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

Background This study aimed to investigate the risk of death by suicide, other externally caused injuries (ECIs), or cardiovascular disease for patients with cancer. Methods We used data from the National Cancer Registry, which include the entire population in Japan. Patients diagnosed with cancer from January 1 to December 31, 2016 were included, and their follow‐up period was set to 2 years. The standardized mortality ratio (SMR) of death by suicide, other ECIs, and cardiovascular disease was calculated compared with the general population. Multivariate Poisson or negative binomial regression analysis was used to quantify the adjusted relative risks of factors of interest. Results We evaluated 1,070,876 patients with cancer. The 2‐year follow‐up SMR was 1.84 (95% confidence interval [CI]: 1.71–1.99) for suicide, 1.30 (95% CI: 1.24–1.37) for other ECIs, and 1.19 (95% CI: 1.17–1.21) for cardiovascular disease. The SMR was higher with shorter follow‐up periods but was significant 13–24 months after cancer diagnosis. The SMRs at 0–1 month and 13–24 months, respectively, were 4.40 (95% CI: 3.51–5.44) and 1.31 (95% CI: 1.14–1.50) for suicide; 2.27 (95% CI: 1.94–2.63) and 1.27 (95% CI: 1.18–1.37) for other ECIs; and 2.38 (95% CI: 2.27–2.50) and 1.07 (95% CI: 1.04–1.10) for cardiovascular disease. The multivariate analyses showed that patients with cancers other than localized tumors had significantly high relative risks of death for each cause. Conclusion Suicide prevention countermeasures for patients with cancer, especially those with advanced disease immediately after diagnosis, are warranted.

show abstract

Immediate risk of non-cancer deaths after a cancer diagnosis

Cited by 14 publications

References 37 publications

Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States

Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States

Cause of Death Among Patients With Thyroid Cancer: A Population-Based Study

Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population‐based study in Japan (J‐SUPPORT 1902)

Contact Info

Product

Resources

About