Immediate separation of microneedle tips from base array during skin insertion for instantaneous drug delivery

Jun, Hyesun; Ahn, Myun-Hwan; Choi, In-Jeong; Baek, Seungin; Park, Jung Hwan; Choi, Seong-O

doi:10.1039/c8ra02334d

Cited by 40 publications

(22 citation statements)

References 26 publications

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“…Whilst the delivery efficiency may not be as important for a vaccine, where only enough vaccine must be delivered to trigger the immune response, drugs with a narrow therapeutic window will require a specific dose to be delivered transdermally. The IRMNs in this study delivered almost all of the coated [197]. b SEM images of an a single-walled stand (left), and an insertion-responsive MN with a single-walled stand (right).…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 90%

“…Pedestal-based MNs (also known as pillar integrated MNs) have an extended length to counteract the elasticity of the skin and provide additional mechanical strength to aid in successful penetration/insertion [193][194][195][196][197]. Taking this into account, pillars could be fabricated by a dissolvable polymer, e.g., PVP or PVA, which dissolve immediately https://doi.org/10.1007/s40820-021-00611-9 © The authors after insertion of MNs into the skin.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

“…One study investigated the effect of base geometry (with or without a walled square pyramid stand) on the mechanical behavior of IRMNs (Fig. 15 ) [ 197 ]. Pyramidal and square hyaluronic acid MN tips with a polycaprolactone base were manufactured.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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Section: Strategies To Enhance Mn Insertionmentioning

confidence: 90%

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…In addition, the microneedle tip was separated within 2 min from the base substrate, which was composed of a foamable material (Li et al 2019b ). Jun et al developed insertion-responsive microneedles for immediate separation of the microneedle after skin application (Jun et al 2018 ). A small single wall was designed on the side of the microneedle base; the structure enabled rapid mechanical separation of the tip from base.…”

Section: Introductionmentioning

confidence: 99%

Microneedle for transdermal drug delivery: current trends and fabrication

Jung

Jin

2021

J. Pharm. Investig.

224

127

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Background Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. Area covered The dose, delivery rate, and efficacy of the drugs can be controlled by the microneedle design and drug formulations. This review introduces the types of microneedles and their design, materials used for fabrication, and manufacturing methods. Additionally, recent biological applications and clinical trials are introduced. Expert opinion With advancements made in formulation technologies, the drug-loading capability of microneedles can be improved. 3D printing and digital technology contribute to the improvement of microneedle fabrication technology. However, regulations regarding the manufacture of microneedle products should be established as soon as possible to promote commercialization.

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“…With the help of the beveled-tip needle, percutaneous interventions and therapies have been widely involved in current clinical procedures, such as brachytherapy [1,2], tissue biopsy [3,4], and drug delivery [5,6]. In intervention procedures, less needle misplacement will lead to a more reliable treatment and a more accurate medical practice.…”

Section: Introductionmentioning

confidence: 99%

Tip Estimation Method in Phantoms for Curved Needle Using 2D Transverse Ultrasound Images

Song

Liu

et al. 2019

Applied Sciences

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Flexible needles have been widely used in minimally invasive surgeries, especially in percutaneous interventions. Among the interventions, tip position of the curved needle is very important, since it directly affects the success of the surgeries. In this paper, we present a method to estimate the tip position of a long-curved needle by using 2D transverse ultrasound images from a robotic ultrasound system. Ultrasound is first used to detect the cross section of long-flexible needle. A new imaging approach is proposed based on the selection of numbers of pixels with a higher gray level, which can directly remove the lower gray level to highlight the needle. After that, the needle shape tracking method is proposed by combining the image processing with the Kalman filter by using 3D needle positions, which develop a robust needle tracking procedure from 1 mm to 8 mm scan intervals. Shape reconstruction is then achieved using the curve fitting method. Finally, the needle tip position is estimated based on the curve fitting result. Experimental results showed that the estimation error of tip position is less than 1 mm within 4 mm scan intervals. The advantage of the proposed method is that the shape and tip position can be estimated through scanning the needle’s cross sections at intervals along the direction of needle insertion without detecting the tip.

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Immediate separation of microneedle tips from base array during skin insertion for instantaneous drug delivery

Abstract: Insertion-responsive microneedles (IRMNs) have been developed that can enable instantaneous drug delivery without applying patches through immediate tip separation upon insertion.

Cited by 40 publications

References 26 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Microneedle for transdermal drug delivery: current trends and fabrication

Tip Estimation Method in Phantoms for Curved Needle Using 2D Transverse Ultrasound Images

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