Immersion vaccines against <i>Yersinia ruckeri</i> infection in rainbow trout: Comparative effects of strain differences

He, Yanan; Ding, Zhujin; Marana, Moonika Haahr; Dalsgaard, Inger; Jaafar, Rzgar M.; Mathiessen, Heidi; Asma, Karami M.; Kania, Per W.; Buchmann, Kurt

doi:10.1111/jfd.13507

Cited by 25 publications

(11 citation statements)

References 72 publications

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“…A recent study reported the effect of ERM immersion vaccines against the pathogen Yersinia ruckeri in the rainbow trout, Oncorhynchus , mykiss based on both biotypes 1 and 2 with serotype O1 (Yang et al 2021 ). They showed that both vaccine biotypes 1 and 2 can protect the fish against the infection.…”

Section: Current Status Of Fish Vaccines and Its Applications-mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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Globally, aquaculture has faced serious economic problems due to bacterial, viral, and various other infectious diseases of different origins. Even though such diseases are being detected and simultaneously treated with several therapeutic and prophylactic methods, the broad-spectrum activity of vaccines plays a vital role as a preventive measure in aquaculture. However, treatments like use of antibiotics and probiotics seem to be less effective when new mutant strains develop and disease causing pathogens become resistant to commonly used antibiotics. Therefore, vaccines developed by using recent advanced molecular techniques can be considered as an effective way of treating disease causing pathogens in aquatic organisms. The present review emphasizes on the current advances in technology and future outlook with reference to different types of vaccines used in the aquaculture industries. Beginning with traditional killed/inactivated and live attenuated vaccines, this work culminates in the review of modern new generation ones including recombinant, synthetic peptides, mucosal and DNA, subunit, nanoparticle-based and plant-based edible vaccines, reverse vaccinology, and monovalent and polyvalent vaccines.

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Section: Current Status Of Fish Vaccines and Its Applications-mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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“…The earliest response of IgM gene was recorded at 72 h after exposure to betanodavirus in European seabass [ 32 ]. Similarly, Yang et al [ 50 ] reported an increase in CD8-α gene expression in rainbow trout at 5 days post-challenge with Yersinia ruckeri . Although the detection of the expression of adaptive immune gene was unsuccessful in our study, evidence of an adaptive immune response was demonstrated with outstanding ELISA antibody titer detected from the challenged vaccinated fish.…”

Section: Discussionmentioning

confidence: 87%

Immune Activation Following Vaccination of Streptococcus iniae Bacterin in Asian Seabass (Lates calcarifer, Bloch 1790)

Tanpichai

Chaweepack²,

Senapin

et al. 2023

Vaccines

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Juvenile Asian seabass (Lates calcarifer) (body weight 10 ± 0.7 g) were intraperitoneally injected with 1012 CFU fish−1 of formalin-killed Streptococcus iniae. The protective efficacy of the vaccine on survival and infection rate was assessed upon challenge at 4, 8, 12, 20, and 28 weeks post-vaccination. The results revealed that the challenged vaccinated fish showed no mortality at all time points, and the control fish presented 10–43.33% mortality. The infection rate at 2 weeks post-challenge was 0–13.33% in the vaccinated fish and 30–82.35% in the control group. At 8 weeks post-vaccination, the vaccinated fish showed comparable ELISA antibody levels with the control; however, the antibody levels of the vaccinated fish increased significantly after the challenge (p < 0.05), suggesting the presence of an adaptive response. Innate immune genes, including MHC I, MHC II, IL-1β, IL-4/13B, and IL-10, were significantly upregulated at 12 h post-challenge in the vaccinated fish but not in the control. In summary, vaccination with S. iniae bacterin provided substantial protection by stimulating the innate and specific immune responses of Asian seabass against S. iniae infection.

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“…Because both the infection dose and the exposure time were well within the ranges where Y. ruckeri can cause mortalities in O. mykiss [ 78 , 79 ], it is likely that the bacterial isolate ( Y. ruckeri O1 biotype 2 100415-1/4) was of low virulence. Indeed, other studies using the same isolate did not result in mortalities [ 80 ]. The only recorded mortalities occurred in the fish that had received the diet supplemented with the highest doses of β-glucan, although this difference was probably not meaningful.…”

Section: Discussionmentioning

confidence: 95%

Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)

et al. 2022

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Background Prebiotics are known to have a positive impact on fish health and growth rate, and β-glucans are among the most used prebiotics on the market. In this study, rainbow trout (Oncorhynchus mykiss) were treated with a β-1,3;1,6-glucan dietary supplement (at a dose of 0 g, 1 g, 10 g, and 50 g β-glucan per kg of feed). After 6 weeks, the effect of the β-glucan was evaluated by determining the changes in the microbiota and the blood serum metabolites in the fish. The impact of β-glucan on the immune system was evaluated through a challenge experiment with the bacterial fish pathogen Yersinia ruckeri. Results The microbiota showed a significant change in terms of composition following β-glucan treatment, notably an increase in the relative abundance of members of the genus Aurantimicrobium, associated with a decreased abundance of the genera Carnobacterium and Deefgea. Furthermore, analysis of more than 200 metabolites revealed that the relative levels of 53 metabolites, in particular compounds related to phosphatidylcholines, were up- or downregulated in response to the dietary supplementation, this included the amino acid alanine that was significantly upregulated in the fish that had received the highest dose of β-glucan. Meanwhile, no strong effect could be detected on the resistance of the fish to the bacterial infection. Conclusions The present study illustrates the ability of β-glucans to modify the gut microbiota of fish, resulting in alteration of the metabolome and affecting fish health through the lipidome of rainbow trout.

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Immersion vaccines against Yersinia ruckeri infection in rainbow trout: Comparative effects of strain differences

Cited by 25 publications

References 72 publications

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

Immune Activation Following Vaccination of Streptococcus iniae Bacterin in Asian Seabass (Lates calcarifer, Bloch 1790)

Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)

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