Immnunohistochemical detection of phthalate esters in the alimentary canal of Tilapia spp.

Abstract

An examination of the occurrence and distribution of phthalate esters in the alimentary canal of a polyhybrid of Tilapia gave evidence of different and selective patterns of distribution in the organ tissues: the phthalate esters were shown to be concentrated in the stomach and anterior intestine. The restricted distribution of phthalate esters can have implications for the physiology of the digestive system. The phthalates, stored in the oxyntic cells of the gastric tubular glands, probably interfere with the digestive process. The strategic location of the enterocytes in the anterior intestine implies that they can hamper the reabsorption of digestion products. The endocrine disrupting effects known for these chemicals are probably related to the absorption of them via the alimentary canal.

Toxic Effects on the Nonspecific Immune System of the Rock Bream Oplegnathus fasciatus upon Exposure to Di-2-ethylhexyl Phthalate

“…The high GOT and GPT activity in rock bream treated with 800-mg DEHP/kg BW indicated a greater degree of hepatic dysfunction in immunosuppressed fish. The different responses of the immune system in spleen and head kidney leukocytes might have resulted from differences in the toxicity and distribution pattern of PEs in the organs of fish, as suggested by Menghi et al (2002). Furthermore, the lack of significant changes in GOT and GPT activity also suggested normal hepatic function in fish treated with low DHEP concentrations.…”