Immobilization and electrochemical behavior of gold nanoparticles modified leukemia K562 cells and application in drug sensitivity test

Gold nanoparticle-based electrochemical biosensors

“…Leukemia K562 cells were immobilized in a microporous cellulose membrane modified with colloidal gold nanoparticles. The electrochemical response from cells was used to evaluate the effectiveness of anti-tumor drug methotrexate [94].…”

Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid–gold nanoparticle conjugates in K562 cells via singlet oxygen generation

“…21 Accordingly, we chose cationic GNPs as carriers to deliver drugs to bind to leukemia K562 cells, which have a negative surface charge. 22 In addition, in recent demonstrations combining nanomaterials with PSs, GNPs not only facilitated delivery of PS to tumor cells but were also better for enhancing the singlet oxygen yield of PpIX.…”

A new disposable electrode for electrochemical study of leukemia K562 cells and anticancer drug sensitivity test

“…et al, 2009), implying that the origin of this irreversible anodic peak from some endogenous electroactive species commonly existing in the different cells. Ju et al proposed that the electroactive center of the cells was the guanine presented in the cytoplasm of the living cells, and the conversion of guanine to 8-oxo-guanine led to the irreversible electrochemical response Yan et al, 2007). During the electrochemical process, the guanine molecules within the cytoplasm of the cells were able to cross the cell membrane rapidly.…”