Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties

Abraham, Gustavo Abel; Queiroz, Álvaro Antônio Alencar de; Román, Julio San

doi:10.1016/s0142-9612(01)00289-7

Cited by 43 publications

(23 citation statements)

References 59 publications

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“…[32,33] Adsorption of fibrinogen from the blood is known to accelerate platelet adhesion and formation of thrombosis on foreign surfaces which show low binding amounts for fibrinogen are more biocompatible. [34][35][36] According to our results, the silicon wafer, the undoped, and the doped SiNWs have quite low fibrinogen adsorption values, demonstrating that they are quite heamocompatible. We note that on the fibrinogen column, first line is the amount of free fibrinogen in the plasma and others indicate the amount of adsorbed fibrinogen on the Si wafer, the undoped, and doped SiNW surfaces.…”

Section: Heamocompatibilitymentioning

confidence: 97%

In Vitro Biocompatibility of n‐Type and Undoped Silicon Nanowires

et al. 2010

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The biocompatibility of undoped and n‐type silicon nanowires (SiNWs), synthesized by metal‐catalyzed chemical vapor deposition, was investigated in vitro, and compared with that for SiO2‐coated silicon wafers. In cell interaction studies, L929 mouse fibroblast cells were used, in which MTT assay, AO/PI dye staining, cell proliferation/growth, and changes in cell adhesion/morphology on the surfaces were applied and investigated. Heamocompatibility of these materials were also tested. No significant cytotoxic effects were observed for either the undoped or for the n‐type phosphorus‐doped SiNWs. The cells on the nanowires exhibit high viability, normal nuclear, and morphological structure. They have shown no considerable negative blood response with respect to the control.

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Section: Heamocompatibilitymentioning

confidence: 97%

In Vitro Biocompatibility of n‐Type and Undoped Silicon Nanowires

et al. 2010

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“…Films were prepared by the solution casting from the solutions of the mixtures. The solvent was slowly evaporated at room temperature for 2 days in a desiccator cabinet followed by vacuum drying overnight at 60 o C. The crosslinking reaction was performed by heating the film in a vacuum oven at 120 o C for 3 h. 7 In the preliminary experiment, it was found that the viscosity of blends containing above 40 wt% of MPU was too high to control film thickness and smoothness. The simple blends films containing above 40 wt% of MPU were found to be dissolved completely in water at 37 o C within 48 h. The MPU content should be higher to improve the properties of blends.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6] Although many successful results have been obtained when using polyurethanes in different biomedical devices, such as vascular prostheses, heat valves, blood pumps and artificial hearts, the inherent thrombogenicity of segmented polyurethanes has been a problem. 7 Therefore, the development of non-thrombogenic biomaterials has remained one of the most elusive challenges in biomaterial field.…”

Section: Introductionmentioning

confidence: 99%

Properties of Blood Compatible Crosslinked Blends of Pellethene®/Multiblock polyurethanes containing phospholipid moiety/C-18 alkyl chain

Yoo

Kim

2008

Macromol. Res.

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To improve the mechanical properties, dimensional stability and blood compatibility, the biomedical material Pellethene ® was blended with multiblock polyurethane (MPU) containing phospopholipid /long alkyl chain (C-18) at the various MPU contents and crosslinked using dicumyl peroxide as a crosslinking agent. The maximum MPU content for stable Pellethene ® /MPU blended films was approximately 30 wt%. The optimum crosslinking agent content and crosslinking time with respect to the mechanical properties were 4 wt% and 3 h, respectively. The mechanical properties (tensile strength and elongation at break) and water absorption of the crosslinked blend film increased with increasing MPU content. The test of platelet adhesion on the surfaces of the crosslinked blend film showed a decrease in the level of platelet adhesion from 70% to 6% with increasing MPU content from 0 to 30 wt%. These results suggest that the crosslinked Pellethene ® /MPU-30 (MPU content: 30 wt%) sample has strong potential as a novel material for blood compatible material applications.

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“…Although many successful results have been obtained when using polyurethanes in different biomedical devices, such as vascular prostheses, heart valves, blood pumps, and artificial hearts, the inherent thrombogenicity of segmented polyurethanes has a problem [7]. Therefore, the development of non-thrombogenic biomaterials has remained one of the most elusive challenges in biomaterial science for decades.…”

Section: Introductionmentioning

confidence: 99%