Immobilization of antibacterial metallic cations (Ga 3+ , Zn 2+ and Co 2+ ) in a polypyrrole coating formed on Nitinol

Saugo, Melisa; Brugnoni, Lorena Inés; Flamini, Daniel Omar; Saidman, S.B.

doi:10.1016/j.msec.2018.01.009

Cited by 20 publications

(12 citation statements)

References 31 publications

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“…In recent years, the development of antimicrobial coatings for Nitinol internal fixators has attracted increasing attention, and the introduction of antimicrobial coatings will further reduce the risk of infection in conjunction with traditional antibiotic treatment. [53][54][55] Regarding antibacterial strategies for orthopedic internal fixators, a common infection of fracture is a serious complication of internal fixation surgery. The incidence of infection after internal fixation can range from 1% of closed femoral fractures to 67% of open pilon fractures.…”

Section: Implantable Devicesmentioning

confidence: 99%

Nitinol: From historical milestones to functional properties and biomedical applications

Alipour

Taromian

Ghomi

et al. 2022

Proc Inst Mech Eng H

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Isoatomic NiTi alloy (Nitinol) has become an important biomaterial due to its unique characteristics, including shape memory effect, superelasticity, and high damping. Nitinol has been widely used in the biomedical field, including orthopedics, vascular stents, orthodontics, and other medical devices. However, there have been convicting views about the biocompatibility of Nitinol. Some studies have shown that Nitinol has extremely low cytotoxicity, indicating Nitinol has good biocompatibility. However, some studies have shown that the in-vivo corrosion resistance of Nitinol significantly decreases. This comprehensive paper discusses the historical developments of Nitinol, its biomedical applications, and its specific functional property. These render the suitability of Nitinol for such biomedical applications and provide insights into its in vivo and in vitro biocompatibility in the physiological environment and the antimicrobial strategies that can be applied to enhance its biocompatibility. Although 3D metal printing is still immature and Nitinol medical materials are difficult to be processed, Nitinol biomaterials have excellent potential and commercial value for 3D printing. However, there are still significant problems in the processing of Nitinol and improving its biocompatibility. With the deepening of research and continuous progress in surface modification and coating technology, a series of medical devices made from Nitinol are expected to be released soon.

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Section: Implantable Devicesmentioning

confidence: 99%

Nitinol: From historical milestones to functional properties and biomedical applications

Alipour

Taromian

Ghomi

et al. 2022

Proc Inst Mech Eng H

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“…[26] Among the many antibacterial ions available, gallium and cerium show interesting properties. [27][28][29][30][31][32][33][34] The antibacterial effect provided by gallium is called "the Trojan horse strategy" [35] as gallium is introduced easily into bacteria due to similarities with iron (Fe). This approach is a nonspecific and effective way of inducing metabolic distress in fast-growing cells such as bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Each year, the USA spends ≈$20 billion in treating infections caused by antibiotic‐resistant bacteria . Among the many antibacterial ions available, gallium and cerium show interesting properties . The antibacterial effect provided by gallium is called “the Trojan horse strategy” as gallium is introduced easily into bacteria due to similarities with iron (Fe).…”

Section: Introductionmentioning

confidence: 99%

Gallium‐ and Cerium‐Doped Phosphate Glasses with Antibacterial Properties for Medical Applications

et al. 2020

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Novel cerium‐ (Ce) and gallium (Ga)‐doped phosphate glasses (PGs) are successfully obtained by the peroxidation method. The new glasses are characterized using Fourier‐transform infrared spectroscopy (FTIR), Raman spectroscopy, X‐ray diffraction, inductively coupled plasma‐optical emission spectroscopy (ICP‐OES), and pH measurements. A strong correlation between glass properties and their composition is found. The incorporation of Ga/Ce in the glass structure is confirmed by peak shifts in Raman and FTIR spectra. Degradation tests conducted in water confirm the soluble character of the PGs and reveal the influence of Ga and Ce on the degradation rate. Ga‐doped glasses are found to be less soluble than Ce‐doped ones (43%, 33%, 21%, and 16% of dry mass remained after 7 weeks for 7Ga, 5Ga, 5Ce, and 7Ce, respectively). Biological evaluation using ST‐2 cells shows adequate cell response with a cell viability of 80% measured using the indirect contact method depending on the composition. The cell viability decreases with an increase in Ga content and increases with Ce content. The antibacterial character of Ga/Ce‐doped PGs is confirmed by turbidity measurements against Escherichia coli and Staphylococcus carnosus. The novel Ce/Ga‐doped PGs exhibiting antibacterial properties and biocompatibility reported here are interesting for tissue engineering and wound healing applications.

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“…Its biocompatibility results from the presence of a thin protective titanium dioxide surface layer that enhances the corrosion resistance and reduces the release of Ni 2+ ions,, which are cytotoxic and carcinogen ,,. A great deal of attention has been paid to the surface modification of NiTi in order to impart and/or improve surface properties such as biocompatibility,, bioactivity, and corrosion resistance ,,…”

Section: Introductionmentioning

confidence: 99%

“…Polypyrrole (PPy) has been reported to act as corrosion inhibitor, a biocompatible material with potential applications, such as in osteointegration stimulation, and growth of endothelial cells . Few works devoted to PPy on NiTi have been reported;,, this is probably due to limitations of the anodic electropolymerization on oxidisable metals and alloys which leads to nickel oxidation and dissolution affecting the film formation and/or its adhesion …”

Section: Introductionmentioning

confidence: 99%

Nitinol Modified by In Situ Generated Diazonium Salts as Adhesion Promoters for Photopolymerized Pyrrole

et al. 2018

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There is a growing demand for biomaterials, however their interaction with living tissues requires their modification by protective and biocompatible coatings. In this context, the present work investigates the electrografting of in situ generated aminophenyl diazonium (PD-NH 2 ) on Nitinol (NiTi). The PD-NH 2 grafting protects the TiO 2 surface layer of NiTi and enhances the blocking properties towards Ru(NH 3 ) 6 Cl 3 used as redox probe. Hypotheses on the interfacial bond between NiTi and the grafted PD-NH 2 layer are proposed. Post-modification is performed by photopolymerization of pyrrole using electrografted PD-NH 2 and PDÀ Py (4-pyrrolyphenyldiazonium) as adhesion promoters. These NiTi surface treatments lead to the formation of well adherent silver-polypyrrole (PPyÀ Ag) nanocomposite films.

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Immobilization of antibacterial metallic cations (Ga 3+ , Zn 2+ and Co 2+ ) in a polypyrrole coating formed on Nitinol

Cited by 20 publications

References 31 publications

Nitinol: From historical milestones to functional properties and biomedical applications

Nitinol: From historical milestones to functional properties and biomedical applications

Gallium‐ and Cerium‐Doped Phosphate Glasses with Antibacterial Properties for Medical Applications

Nitinol Modified by In Situ Generated Diazonium Salts as Adhesion Promoters for Photopolymerized Pyrrole

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