Immobilization of chlorophyll by using layer-by-layer technique for controlled release systems and photodynamic inactivation

Gorza, Filipe D.S.; Silva, Romário J. da; Trescher, Tarquin F.; Pedro, Graciela C.; Sousa, Maria A. Oliveira de; Souto, Paula C. S.; Silva, Josmary R.; Souza, Nara C. de

doi:10.1016/j.pdpdt.2016.06.010

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Thus, in order to preserve the monomeric state of the PS, to protect it from aqueous environment, and to increase the efficacy of photodynamic treatment, several transporters and delivery systems, such as liposomes, have also been developed in the last few years. Liposomes became known due to their high loading capacity, biodegradability, biocompatibility, and size [ 153 ]. In fact, these liposomal vesicles with one or more concentric phospholipid bilayer(s) have two main advantages in PDI ( Figure 31 ).…”

Section: Liposomesmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Liposomesmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…The relation between α and df of a surface can be obtained by: df = D-α, where D is the dimension of the space observed [39]. The interface-forming process that determines the surface morphology can be investigated using fractal concepts and dynamic-scale laws [39,40], which can be done by analyzing the log-log dependency of W as a function of the scan window length (L). In the linear region, wherein the laws of scale are satisfied, the value of the angular coefficient gives α [39].…”

Section: Discussionmentioning

confidence: 99%

Latex membranes with methylene blue dye for antimicrobial photodynamic therapy

Sousa

Faria

Ribeiro

et al. 2021

Photochem Photobiol Sci

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The search for new materials that can be applied in the treatment of injured human tissues has led to the development of new dressings. Membranes have potential as dressing materials because they can be fitted to and interact with the tissue surface. In this study, we analyze the morphological properties and wettability of latex membranes, along with the incorporation of the photosensitizer methylene blue, in the context of the utility of the membranes in curative applications involving photodynamic therapy (PDT). It was observed that deposition of the photosensitizer into latex membranes increased both the surface roughness and wettability. Antifungal testing indicated that antimicrobial PDT assisted by the latex membranes incorporating methylene blue effectively inactivated Candida albicans.

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“…The low concentration of PS ensures that it is possible to observe colony growth after PDI, as indicated by Freire et al [11] who observed that higher concentrations of eosin lead to cell death. To prepare fungal dispersions, one isolated colony was seeded from the original culture onto a Sabouraud agar plate and incubated at 37 °C for 24 h. Subsequently, 9.0 mg of the resulting culture was dispersed in 10 mL of physiological solution or in 10 mL of eosin solution (for inactivation experiments) [12][13][14].…”

Section: Methodsmentioning

confidence: 99%

Growth models of fractal interfaces in the description of microorganism colony growth: effect of photodynamic inactivation

Trescher

Silva

Souto

et al. 2022

Photochem Photobiol Sci

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Candida albicans is responsible for most of the nosocomial infections that affect immunocompromised individuals. We investigated the application of eosin in photodynamic inactivation as a strategy in the inhibition of the growth of C. albicans and the morphological variation and growth dynamics in light of fractal theory. The damage caused to fungal structures alters the roughness of the colony, and these changes were described by parameters that were defined by mathematical models. Proliferation of the fungi should be inhibited in the center of the colonies and the analysis of the edges gives an indication about the dynamics of growth and cell reproduction.

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Immobilization of chlorophyll by using layer-by-layer technique for controlled release systems and photodynamic inactivation

Cited by 7 publications

References 34 publications

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Latex membranes with methylene blue dye for antimicrobial photodynamic therapy

Growth models of fractal interfaces in the description of microorganism colony growth: effect of photodynamic inactivation

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