Immobilized [Cu(cdsalMeen)] on silica gel: a highly efficient heterogeneous catalyst for ‘Click’ [3 + 2] Huisgen cycloaddition

Zarenezhad, Elham; Rad, Mohammad Navid Soltani; Behrouz, Somayeh; Esmaielzadeh, Sheida; Farjam, Mojtaba

doi:10.1007/s13738-016-0999-3

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…In continuation of our interests and also ongoing researches in the field of copper heterogeneous nano-catalysts and also design and synthesis of new 1,2,3-triazolyl conjugate compounds [26][27][28][29][30], hereby, we would like to report the synthesis and characterization of hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for the synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents 11 (Fig. 2).…”

Section: Introductionmentioning

confidence: 73%

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

et al. 2021

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The preparation, characterization and application of hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as promising antifungal agents have been described. HASPBAEECC is fully characterized by different microscopic, spectroscopic and physical techniques, including scanning electron microscopy (SEM), transmission, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA) and FT-IR. The ʻClick̕ Huisgen cycloaddition reaction of N-propargyl benzimidazole with diverse azidoalkyls in a THF-water media at ambient temperature provides the products in good-to-excellent yields using HASPBAEECC. HASPBAEECC is proved to be a stable, low cost, reusable and environmentally benign nanohybrid catalyst. The target compounds were screened against some pathogenic fungal comprising Candida albicans, Candida krusei, Candida parapsilosis, Aspergillus fumigatus and Aspergillus flavus in which it was determined that compounds 11f and 11 h have displayed promising antifungal activity similar to fluconazole as a reference drug.

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Section: Introductionmentioning

confidence: 73%

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

et al. 2021

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“…Since the considerable therapeutic activities of N-heterocyclic compounds 70 were demonstrated and also in continuation of our interest in discovering copper(II) Schiff base complexes [71][72] and the new N-heterocyclic bioactive compounds, [73][74][75][76][77][78][79] herein we report the application of a suitable and reusable Cu(II)-curcumin complex supported on silica gel and ascorbic acid as the reducing agent. This heterogeneous catalyst system exhibits a potent catalytic activity for the synthesis of some 5-substituated-1H-tetrazole derivatives tethered to bioactive N-heterocyclic cores.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antifungal Evaluation and Molecular Docking Studies of Some Tetrazole Derivatives

Afsarian

Farjam

Zarenezhad

et al. 2019

ACSi

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“…Heterocyclic organic chemistry is a main field in organic and medicinal chemistry [ 1 – 4 ]. Azoles are nitrogen- containing five-membered heterocyclic compounds [ 5 , 6 ]. The presence of nitrogen in heterocycles has a major effect on biological activity.…”

Section: Introductionmentioning

confidence: 99%

Novel 1, 2, 4-Triazoles as Antifungal Agents

Kazeminejad

Marzi

Shiroudi

et al. 2022

BioMed Research International

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The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity.

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Immobilized [Cu(cdsalMeen)] on silica gel: a highly efficient heterogeneous catalyst for ‘Click’ [3 + 2] Huisgen cycloaddition

Cited by 17 publications

References 33 publications

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

Synthesis, Antifungal Evaluation and Molecular Docking Studies of Some Tetrazole Derivatives

Novel 1, 2, 4-Triazoles as Antifungal Agents

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