Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications

Sotiri, Irini; Overton, Jonathan C.; Waterhouse, Anna; Howell, Caitlin

doi:10.1177/1535370216640942

Cited by 91 publications

(101 citation statements)

References 67 publications

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“…The same authors also demonstrated higher number of adhered bacteria cultured under dynamic conditions in comparison to the static conditions. [98] An excellent review about antiadhesion properties of SLIPS for medical applications including antibacterial and antithrombogenic uses of SLIPS has been recently published by Sotiri et al [15] SLIPS based on medically relevant materials (such as expanded polytetrafluoroethylene and perfluoroperhydrophenanthrene) was prepared, coated onto the implant surface, and then studied in a rat model. [95] The prepared SLIPS showed good in vivo stability and could enable bacterial elimination at the implant surface, while showing low innate immune response as well as reduced inflammatory capsule formation.…”

Section: Cell-repellent and Antibiofouling Slipsmentioning

confidence: 99%

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Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

192

138

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Bioinspired lubricant-infused surfaces exhibit various unique properties attributed to their liquid-like and molecularly smooth nature. Excellent liquid repellency and "slippery" properties, self-healing, antiicing, anticorrosion characteristics, enhanced heat transfer, antibiofouling, and cell-repellent properties have been already demonstrated. This progress report highlights some of the recent developments in this rapidly growing area, focusing on properties of lubricant-infused surfaces, and their emerging applications as well as some future challenges.coatings. [8] In order to solve the abovementioned limitations of traditional superhydrophobic and superoleophobic surfaces, Quéré, Aizenberg, and Varanasi proposed bioinspired slippery liquidinfused porous surface (SLIPS) or lubricant-impregnated surfaces combining the mechanical stability of a solid substrate with the liquid-like properties and molecularly smoothness of the lubricant interface. [9a-d] It should be noted that stabilization of a lubricant layer on solid surfaces by forming a thin polymer film that can be swollen in the lubricant was introduced in 1988 by Karakelle and Zdrahala from Bekton, Dickinson and Company.[9e] They also demonstrated excellent long-term stability, liquid repellency, and proposed various medical applications of lubricant-impregnated surfaces. SLIPSs mimic the Nepenthes pitcher plant surface, [10] which is textured and can be lubricated with an aqueous solution. [11] The unique slippery character of the [9a] Nepenthes pitcher plant's surface resulting from water lubrication helps it capture insects sliding into its interior. To mimic the Nepenthes pitcher plant surface, a lubricating hydrophobic liquid can be infused into different hydrophobic porous or rough substrates to form SLIPS. [9] By matching the surface energy of the underlying porous substrate and the hydrophobic lubricant, the liquid can be stabilized on the surface of the substrate to form SLIPS. [9a] Depending on the impregnated lubricant, SLIPSs possess excellent repellency and drop mobility to a broad range of liquids including low surface tension liquids, and complex fluids such as blood or cell medium. [9a] This liquid repellency as well as SLIPS′ self-healing properties are due to the mobility of the lubricant trapped inside the porous surface structures. [12] Lubricant-infused surfaces demonstrated icephobic, stainresistant, biofilm-or cell-repellent or marine antibiofouling properties as well as tolerance to high pressure and transparency. [9,13] All of these unique properties make SLIPS interesting for the development of novel functional materials and various practical applications.The goal of this progress report is not to comprehensively review this broad and dynamic research field but rather highlight selected important aspects that have been less reviewed so far despite their potential. Some important and related papers could not be cited due to the length limitations. We also refer readers to several excellent reviews covering applications of ...

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Section: Cell-repellent and Antibiofouling Slipsmentioning

confidence: 99%

“…Some important and related papers could not be cited due to the length limitations. We also refer readers to several excellent reviews covering applications of SLIPS for heat transfer and condensation, [14] antibiofouling properties, [15] antiicing properties [16] as well as medically relevant applications. [17]…”

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confidence: 99%

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

192

138

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“…[2] Slippery liquid-infused porous surfaces (SLIPS), inspired by the carnivorous Nepenthes pitcher plant, were recently introduced as a new approach to prevent bacterial biofouling in both industrial and medical applications without the need for administering antibiotics. [3][4][5] This approach represents a paradigm shift in materials science, where instead of a solid surface, bacteria are presented with an inherently dynamic and self-healing immobilized liquid (IL) layer that is held in place by a chemically matched substrate. [3,6,7] Epstein et al were the first to demonstrate that the presence of an IL layer of fluorinated oil on ePTFE significantly reduced biofilm coverage of S. aureus and E. coli (by 97.2% and 96%, respectively) after 48 hours of growth under static conditions, compared to ePTFE without an IL layer.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Interactions with Immobilized Liquid Layers

Kovalenko

Sotiri

Timonen

et al. 2016

Adv Healthcare Materials

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Bacterial interactions with surfaces are at the heart of many infection-related problems in healthcare. In this work, the interactions of clinically relevant bacteria with immobilized liquid (IL) layers on oil-infused polymers are investigated. Although oil-infused polymers reduce bacterial adhesion in all cases, complex interactions of the bacteria and liquid layer under orbital flow conditions are uncovered. The number of adherent Escherichia coli cells over multiple removal cycles increases in flow compared to static growth conditions, likely due to a disruption of the liquid layer continuity. Surprisingly, however, biofilm formation appears to remain low regardless of growth conditions. No incorporation of the bacteria into the layer is observed. Bacterial type is also found to affect the number of adherent cells, with more E. coli remaining attached under dynamic orbital flow than Staphylococcus aureus, Pseudomonas aeruginosa under identical conditions. Tests with mutant E. coli lacking flagella confirm that flagella play an important role in adhesion to these surfaces. The results presented here shed new light on the interaction of bacteria with IL layers, highlighting the fundamental differences between oil-infused and traditional solid interfaces, as well as providing important information for their eventual translation into materials that reduce bacterial adhesion in medical applications.

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“…Currently, various polymeric materials have been investigated and tested as potential anti-adhesion barrier films, including nanosheets, 11 polyvinyl alcohol (PVA)/gelatin membranes, 12 polycaprolactone film, 13 photocrosslinkable gellan gum film, 14 silver nanoparticles-loaded poly(l-lactide) fibrous membranes, 15 chitosan-polyvinyl pyrrolidone film, 16 and immobilized liquid layers. 17 Despite these efforts, the development of drug-loaded anti-adhesion film has been limited. Chen et al 18 were the only research team to propose a silver nanoparticle/ ibuprofen-loaded poly(l-lactide) fibrous membrane and evaluate its anti-infection and anti-adhesion effects.…”

Section: Introductionmentioning

confidence: 99%

Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds

Kao¹,

Lee²,

Wu³

et al. 2017

IJN

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The aim of this study was to develop and evaluate the effectiveness of biodegradable nanofibrous lidocaine/ketorolac-loaded anti-adhesion membranes to sustainably release analgesics on abdominal surgical wounds. The analgesic-eluting membranes with two polymer-to-drug ratios (6:1 and 4:1) were produced via an electrospinning technique. A high-performance liquid chromatography (HPLC) assay was employed to characterize the in vivo and in vitro release behaviors of the pharmaceuticals from the membranes. It was found that all biodegradable anti-adhesion nanofibers released effective concentrations of lidocaine and ketorolac for over 20 days post surgery. In addition, a transverse laparotomy was setup in a rat model for an in vivo assessment of activity of postoperative recovery. No tissue adhesion was observed at 2 weeks post surgery, demonstrating the potential anti-adhesion capability of the drug-eluting nanofibrous membrane. The postoperative activities were recorded for two groups of rats as follows: rats that did not have any membrane implanted (group A) and rats that had the analgesic-eluting membrane implanted (group B). Rats in group B exhibited faster recovery times than those in group A with regard to postoperative activities, confirming the pain relief effectiveness of the lidocaine- and ketorolac-loaded nanofibrous membranes. The experimental results suggested that the anti-adhesion nanofibrous membranes with sustainable elution of lidocaine and ketorolac are adequately effective and durable for the purposes of postoperative pain relief in rats.

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Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications

Cited by 91 publications

References 67 publications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Bacterial Interactions with Immobilized Liquid Layers

Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds

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