Immobilized Ni on TMEDA@βSiO2@αSiO2@Fe3O4: as a novel magnetic nanocatalyst for preparation of pyrido[2,3-d:6,5-d′]dipyrimidines

Аlmajidi, Yasir Q.; Ubaidullah, Mohd; Pandit, Bidhan; Kareem, A K; Romero-Parra, Rosario Mireya; Bobirjon, Adizov; Kadhum, Wesam R.; AL-Erjan, Amran M.; Abosaooda, Munther; Mahmoud, Aisha Kamal

doi:10.1039/d3ra01720f

Cited by 10 publications

(2 citation statements)

References 53 publications

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“…Almajidi and his team (2023) [106] developed an efficient and reusable heterogeneous catalyst, Ni‐TMEDA@ β SiO 2 @aSiO 2 @Fe 3 O 4 , which they used effectively in the synthesis of pyrido[2,3‐ d :6,5‐ d ′] dipyrimidines 108 . This method offers suitable turnover frequency (TOF) and turnover number (TON) values for the synthesis of all derivatives.…”

Section: Synthetic Techniques For the Preparation Of Pyrido[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

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Due to their extensive applications in pharmaceuticals and natural substances, organic synthesis and heterocyclic compounds have been at the forefront of research for many years. Pyrimidine is one of the heterocyclic compounds that have various derivatives with promising biological and pharmacological properties. This review article covers the synthesis and biological effects of pyrimidine derivatives, such as pyrano[2,3‐d]pyrimidines, pyrido[2,3‐d]pyrimidines, and furo[2,3‐d]pyrimidines. The compounds discussed in this review have a wide range of biological activities. Recent advances in green chemistry have led to the development of eco‐friendly synthetic methods for producing these bioactive heterocycles. This review aims to present various synthetic methods and biological effects of these compounds and provide new opportunities for organic chemists to develop potent nitrogen‐ and oxygen‐containing heterocycles for future applications. The review highlights examples of successful syntheses and applications of pyrimidine derivatives in the fields of antibacterial, antifungal, anticancer, enzyme inhibition, and antiviral research.

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Section: Synthetic Techniques For the Preparation Of Pyrido[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

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“…Zeolites, activated carbon, metal–organic frameworks (MOFs), silica supports, alumina supports, and MCM-41 are examples of supports acting as protective matrices in catalysis. In these examples, the supports function as protective matrices by encapsulating, stabilizing, and preventing the aggregation or degradation of active metal species, ultimately contributing to the efficiency and durability of the catalyst system 17 – 23 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N,N′-alkylidene bisamides and Suzuki–Miyaura coupling reaction derivatives with Pd organometallic catalyst anchored to channels of mesoporous silica MCM-41

Ibraheem Shelash Al-Hawary,

Saleh,

AlBajalan

et al. 2024

Sci Rep

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At first, an organometallic catalyst namely, Pd-DPyE@MCM-41@MNP was prepared through magnetic (Fe3O4) nanoparticles-doped into channels of mesoporous silica MCM-41 and then, anchoring a novel complex composed of di(4-pyridyl)ethylene and palladium on the inner surface of the support. This immobilized catalyst was successfully identified via VSM, ICP-OES, TEM, FTIR, TGA, SEM, BET, XRD, EDX and elemental mapping analyses. After that, it was used as a versatile, heterogeneous, and magnetically reproducible catalyst in the generation of N,N′-alkylidene bisamides (1a-13a, 8–20 min, 90–98%, 50 °C, solvent-free) and Suzuki–Miyaura coupling (SMC) reaction derivatives (1b-26b, 10–140 min, 86–98%, 60 °C, PEG-400). The VSM plot of Pd-DPyE@MCM-41@MNP displays that this nanocatalyst can be easily recycled by applying an external magnetic field. In both synthetic paths, this nanocatalyst was reused at least seven times without palladium leaching and significantly reducing its catalytic performance. Also, stability and heterogeneous nature of catalyst were approved via ICP-OES technique and hot filtration test.

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Green Synthesis of Bimetallic Cu−Cd Nanoparticles and its Catalytic Activity in Pyrido [2,3‐d;6,5‐d] Dipyrimidine Derivatives

Kopperundevi,

Ashokkumar,

Gopalakrishnan

et al. 2024

ChemistrySelect

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Green synthesis nanoparticles have gained interest in recent years due to their environmental friendliness and sustainability. The current study focuses on the green synthesis of BMNP using spearmint leaves as a reducing and stabilizing agent. Because of their excellent catalytic characteristics, the synthesized bimetallic nanoparticles function as an effective catalyst in pyrido[2,3‐d:6,5‐d] pyrimidine derivatives. The synthesized nanoparticles are characterized using a variety of techniques, including FT‐IR analysis, SEM & EDX, XRD, and TEM. The FT‐IR study shows a reduction in functional groups in the leaf extract, confirming the metal nanoparticles’ stretching. SEM and EDX studies confirm the shape and elemental composition of bimetallic nanoparticles. XRD investigation showed that the synthesized NPs are crystalline, and the Scherrer equation was used to calculate the average crystallite size. The calculated size was 49 nm. TEM analysis confirms the core‐shell nature of BMNPs. The synthesized nanoparticles acted as a superior catalyst in pyrido[2,3‐d:6,5‐d] dipyrimidines derivatives. in the synthetic procedure, BMNPs enhanced the catalytic activity and reduced the reaction time with more yield, Compared to the previous study. and the synthesized compound [1–5] has been confirmed by FT‐IR, 1H‐NMR, and 13C‐NMR analysis. and it has given better results in in‐vivo anti‐diabetic activity by Streptozotocin nicotinamide. This induced model adult male albino Wistar derivatives show significant fasting blood glucose levels when compared to metformin hydrochloride. and its evaluated molecular docking study, exhibit excellent CDDOCKER energy.

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Immobilized Ni on TMEDA@βSiO₂@αSiO₂@Fe₃O₄: as a novel magnetic nanocatalyst for preparation of pyrido[2,3-d:6,5-d′]dipyrimidines

Abstract: In the current body of research, a very quick and effectual procedure for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines has been developed.

Cited by 10 publications

References 53 publications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Synthesis of N,N′-alkylidene bisamides and Suzuki–Miyaura coupling reaction derivatives with Pd organometallic catalyst anchored to channels of mesoporous silica MCM-41

Green Synthesis of Bimetallic Cu−Cd Nanoparticles and its Catalytic Activity in Pyrido [2,3‐d;6,5‐d] Dipyrimidine Derivatives

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