Immobilizing yeast β-glucan on zinc-layered hydroxide nanoparticle improves innate immune response in fish leukocytes

Velázquez-Carriles, Carlos Arnulfo; Macías-Rodríguez, María Esther; Arízaga, Gregório Guadalupe Carbajal; Silva-Jara, Jorge Manuel; Angulo, Carlos; Reyes‐Becerril, Martha

doi:10.1016/j.fsi.2018.08.055

Cited by 23 publications

(6 citation statements)

References 49 publications

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“…Thermograms of ZnHSL and thymol–ZnHSL are depicted in Figure 6 . For layered hydroxide, similar behaviors have been previously reported [ 16 , 19 ]. On the other hand, thymol–ZnHSL exhibits a first event around 150 °C, where a 10% mass is lost, and that could be related to the thymol surrounding the hydroxide, since this terpene has been reported to reduce its mass drastically between 150 and 200 °C [ 38 ].…”

Section: Resultssupporting

confidence: 88%

“…An example of LM is zinc hydroxide chloride, also known as Simonkolleite, a mineral found in galvanized steel that displays a layered structure that is brucite-like. In this structure, empty spaces are located below and above coordinated Zn, where counter-anions can be intercalated [ 17 ] such as cinnamate [ 18 ] or β-glucan [ 19 ]. Combining these LMs with bioactive compounds may exhibit equal or higher activities of the biomolecule, thus reducing toxicity due to smaller concentrations and production costs [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Nanohybrid of Thymol and 2D Simonkolleite Enhances Inhibition of Bacterial Growth, Biofilm Formation, and Free Radicals

et al. 2022

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Due to the current concerns against opportunistic pathogens and the challenge of antimicrobial resistance worldwide, alternatives to control pathogen growth are required. In this sense, this work offers a new nanohybrid composed of zinc-layered hydroxide salt (Simonkolleite) and thymol for preventing bacterial growth. Materials were characterized with XRD diffraction, FTIR and UV–Vis spectra, SEM microscopy, and dynamic light scattering. It was confirmed that the Simonkolleite structure was obtained, and thymol was adsorbed on the hydroxide in a web-like manner, with a concentration of 0.863 mg thymol/mg of ZnLHS. Absorption kinetics was described with non-linear models, and a pseudo-second-order equation was the best fit. The antibacterial test was conducted against Escherichia coli O157:H7 and Staphylococcus aureus strains, producing inhibition halos of 21 and 24 mm, respectively, with a 10 mg/mL solution of thymol–ZnLHS. Moreover, biofilm formation of Pseudomonas aeruginosa inhibition was tested, with over 90% inhibition. Nanohybrids exhibited antioxidant activity with ABTS and DPPH evaluations, confirming the presence of the biomolecule in the inorganic matrix. These results can be used to develop a thymol protection vehicle for applications in food, pharmaceutics, odontology, or biomedical industries.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Nanohybrid of Thymol and 2D Simonkolleite Enhances Inhibition of Bacterial Growth, Biofilm Formation, and Free Radicals

et al. 2022

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“…The gene expression of MIF in the intestine and spleen was decreased due to β-glucan intake in brackish water. β-glucan has a dual function of both pro-inflammatory mediator production and anti-inflammatory properties [57,58]. In the present study, the enhanced immune response in the spleen induced by environmental salinity could be significantly relieved by dietary β-glucan.…”

Section: Discussionmentioning

confidence: 53%

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

Suo

Wang

et al. 2020

Animals

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Long-term exposure to hyperosmotic environments can induce severe immune damage and increase risk in tilapia breeding. As an effective immunoregulator, β-glucan has attracted extensive attention in nutritional research and given rise to high expectations of improving health status and alleviating organismal damage in tilapia, Oreochromis niloticus, in brackish water. In this study, an 8-week cultivation experiment was conducted on tilapia fed a basal diet or diets with β-glucan supplementation in freshwater (control) and brackish water. Growth performance, hematological aspects, immune cytokine expression, and the intestinal microbiota of tilapia were analyzed. The results indicated that supplementation with β-glucan significantly reduced the enlarged spleen of tilapia resulting from hypersaline stress. Tilapia fed β-glucan showed significantly-greater decreases in the red blood cell count, hematocrit, red cell distribution width, platelet count, and plateletcrit than those fed the basal diet. β-glucan significantly decreased the high expression of immune-related genes in the spleen induced by hyperosmotic stress. In the intestine, the high migration inhibitory factor-2 (MIF-2) and IL-1β gene expression induced by hypersaline stress was significantly reduced. β-glucan supplementation also significantly increased the abundance of beneficial microbiota such as Lactobacillus, Phycicoccus, and Rikenellaceae. Therefore, dietary β-glucan supplementation can significantly reduce spleen enlargement and improve immune function in tilapia in brackish water. β-glucan intake can also optimize the intestinal microbiota of tilapia in brackish water and improve fish health.

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“…Of course, besides production performance, there is also a need to focus on disease control and immunity of livestock in the process of raising livestock. A study has reported that a nanoparticle consisting of laminated hydroxyzine chloride and Fermentum β-polysaccharide, synthesized by ion exchange, stimulated splenic leukocytes of the Lutjanus Peru with a survival rate of more than 80% and that the nanoparticle stimulated the production of pro-inflammatory cytokines better than other drugs, resulting in better immune activity ( Velazquez-Carriles et al, 2018 ). Another study showed that Fermentum β-polysaccharide as a drug could increase specific beneficial colonic microbial communities and improve the intestinal health of weaned piglets, thereby enhancing their immunity ( Leonard et al, 2012 , Venardou et al, 2021 ).…”

Section: Applicationsmentioning

confidence: 99%

An important polysaccharide from fermentum

Lin

Huang²

2022

Food Chemistry: X

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Immobilizing yeast β-glucan on zinc-layered hydroxide nanoparticle improves innate immune response in fish leukocytes

Cited by 23 publications

References 49 publications

Nanohybrid of Thymol and 2D Simonkolleite Enhances Inhibition of Bacterial Growth, Biofilm Formation, and Free Radicals

Nanohybrid of Thymol and 2D Simonkolleite Enhances Inhibition of Bacterial Growth, Biofilm Formation, and Free Radicals

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

An important polysaccharide from fermentum

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