Immortalization of epithelial progenitor cells mediated by resveratrol

Pearce, Virginia; Sherrell, J; Lou, Zhenjun; Kopelovich, L; Wright, Woodring E.; Shay, Jerry W.

doi:10.1038/sj.onc.1210886

Cited by 32 publications

(27 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to its lipophilic character, tissue levels of resveratrol may be higher than those found in plasma (Timmers et al, 2012). Nonetheless, some of the biological effects of resveratrol are observed at very low concentrations (Waite et al, 2005;Pearce et al, 2008), bringing forward the idea that resveratrol exerts its major effects on intestinal tissue, affecting the rest of the body through secondary effects that are independent of the plasma levels reached by the compound . In rodent models, the doses employed normally range from as low as 0.1 mg/kg BW to up to 1000 mg/kg BW, with even higher or lower doses occasionally being used .…”

Section: Bioavailability Of Resveratrol and Plasma Levelsmentioning

confidence: 99%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

View full text Add to dashboard Cite

a b s t r a c tResveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and healthrelated use.

show abstract

Section: Bioavailability Of Resveratrol and Plasma Levelsmentioning

confidence: 99%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

View full text Add to dashboard Cite

show abstract

“…However, this drug is poorly tolerated in many patients, with liver adverse effects and increased risk of venous thrombosis. Drugs targeting telomere homeostasis, such as fluoxetine, cycloastragenol, resveratrol, N-acetylcarnosine or AGS-499, are being evaluated [51][52][53][54][55][56][57].…”

Section: Pulmonary Involvementmentioning

confidence: 99%

Management of suspected monogenic lung fibrosis in a specialised centre

et al. 2017

View full text Add to dashboard Cite

At least 10% of patients with interstitial lung disease present monogenic lung fibrosis suspected on familial aggregation of pulmonary fibrosis, specific syndromes or early age of diagnosis. Approximately 25% of families have an identified mutation in genes mostly involved in telomere homeostasis, and more rarely in surfactant homeostasis.Beyond pathophysiological knowledge, detection of these mutations has practical consequence for patients. For instance, mutations involved in telomere homeostasis are associated with haematological complications after lung transplantation and may require adapted immunosuppression. Moreover, relatives may benefit from a clinical and genetic evaluation that should be specifically managed.The field of genetics of pulmonary fibrosis has made great progress in the last 10 years, raising specific problems that should be addressed by a specialised team.

show abstract

“…With the recent linking of the genes, Forkhead [64], SIRT1 [65], and caloric restriction and extended life span of several organisms, the subsequent demonstration that resveratrol, an anti-oxidant, polyphenol in grapes and red wine, could affect the immortalization of epithelial progenitor cells with a mutated p53 seems to open up another link with adult stem cells, aging and diseases of aging [66]. The amazing observation that resveratrol could improve health and survival of mice on a high-caloric diet, without reducing the weight of the mice [53].…”

Section: Nature and Nurture Of Aging: Interaction Of "Aging Genes" And mentioning

confidence: 97%

Role of Diet and Nutrition on the Alteration of the Quality and Quantity of Stem Cells in Human Aging and the Diseases of Aging

Je¹

2008

CPD

View full text Add to dashboard Cite

An integrative synthesis of concepts and an explosion of experimental and epidemiological findings allow new insights as to how the interactions of genetic, environmental, dietary, cultural (social, psychological, economic) factors can influence the aging and diseases of aging processes. Although the net effect of the best dietary maintenance of homeostatic control of cell proliferation, cell differentiation and apoptosis, systems breakdown of the human being and death will inevitably be the ultimate end result. Reduction of the quantity of the stem cell pool in any tissue will affect the "aging" of that organ. This, in turn, will affect the homeostatic maintenance of the organ systems of the human. Clearly, not all organs of the body age uniformly. The quality of the stem cells in any organ, depending on circumstances, can contribute to various disease pathogeneses. In the case where the quality of the stem cells is altered in utero or early postnatal development by some mutagenic mechanism that could lead to the initiation step of carcinogenesis, then the individual can, to some degree, control the fate of those prenatally and early postnatally-derived initiated stem cells by choosing those environmentally and dietary factors that either enhance or prevent the clonal expansion of these initiated stem cells during the promotion phase of carcinogenesis. This might explain the Barker hypothesis which suggests that prenatal and early postnatal exposures to toxic agents can lead to diseases later in life.

show abstract

Immortalization of epithelial progenitor cells mediated by resveratrol

Cited by 32 publications

References 46 publications

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Management of suspected monogenic lung fibrosis in a specialised centre

Role of Diet and Nutrition on the Alteration of the Quality and Quantity of Stem Cells in Human Aging and the Diseases of Aging

Contact Info

Product

Resources

About