Immune activity of fullerene C60 amino acid and protein derivatives

Self-Assembly of Well-Defined Mono and Dual End-Capped C60 Containing Polyacrylic Acids in Aqueous Solution

“…7,8 However, its applications are hindered by its lack of solubility in common organic and polar solvents. To modify its solubility, several methods have been adopted, such as (1) the formation of complexes with surfactants or cyclodextrins through solubilization or encapsulation, 9,10 (2) the formation of chargetransfer complexes with organic compounds bearing electrondonating groups through electron donor and acceptor interaction, 11 and (3) conjugating polar functional groups such as carboxylic acids, 12 amino acids, 13 amine derivatives, 14,15 and alcohols 16 onto C 60 molecules. Conjugating well-defined polymeric chain to C 60 not only increases the solubility of C 60 but also retains most of its unique properties, which are more amenable to different enduse applications.…”

“…Because of the promising end-use applications of fullerene (C 60 ) , resulting from its outstanding properties, such as electronic, conducting, magnetic, and high cohesive forces between C 60 molecules, the ability to accept and release electrons, and relatively high reactivity that allows for the tailoring of C 60 -based derivatives, interest in C 60 has recently increased. , However, its applications are hindered by its lack of solubility in common organic and polar solvents. To modify its solubility, several methods have been adopted, such as (1) the formation of complexes with surfactants or cyclodextrins through solubilization or encapsulation, , (2) the formation of charge-transfer complexes with organic compounds bearing electron-donating groups through electron donor and acceptor interaction, and (3) conjugating polar functional groups such as carboxylic acids, amino acids, amine derivatives, , and alcohols onto C 60 molecules. Conjugating well-defined polymeric chain to C 60 not only increases the solubility of C 60 but also retains most of its unique properties, which are more amenable to different end-use applications.…”

Synthesis of a Water Soluble, Monosubstituted C60 Polymeric Derivative and Its Photoconductive Properties

“…But a wider application of fullerenes is heavily limited by their poor solubility in aqueous media, especially for biological applications. Now, several approaches have been explored for preparation of water-soluble C 60 derivatives, − such as water-soluble fullerene carboxylic acid derivatives, , fullerene amino acid derivatives, , and peptide-functionalized C 60 derivatives . Bonding of C 60 into water-soluble polymers is another important approach for preparation of water-soluble C 60 derivatives. ,, …”