Immune and autoimmune gluten-related phenomenon in systemic lupus erythematosus

Dima, Alina; Jurcuţ, Ciprian; Bălănescu, Eugenia; Badea, Camelia; Lacatus, N; Popp, Alina

doi:10.1177/0961203317700483

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…In support of the previously stated findings, another study carried out at Colentina Hospital and the Institute for Mother and Child Care, Bucharest, Romania, demonstrated the increase in the prevalence of gluten-induced autoimmunity among patients with SLE compared to the general population, identified for TGA-IgA, but not for EMA [12].…”

Section: Epidemiologysupporting

confidence: 69%

Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat

Lupu,

Jechel,

Mihai

et al. 2023

Nutrients

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Celiac disease (CD) and systemic lupus erythematosus (SLE) are two diseases intensively studied in all age groups, with an increasing incidence at the global level, possibly due to the increased awareness of the diseases and their accurate diagnosis and as a consequence of the new research and innovation technologies that have appeared in medicine. The first is a controllable condition found in approximately 1% of the entire population in the form of a reaction to environmental stimuli affecting individuals with genetic susceptibility, causing gluten intolerance, gastrointestinal and extradigestive symptoms, starting from subclinical stages and culminating in severe malabsorption. On the other hand, lupus is an autoimmune disease with chameleon-like symptoms and found mainly in the female sex, which leaves its clinical mark on most organs, from the skin, eyes, and kidneys to the cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. Current studies focus on the correlation between celiac disease and other autoimmune pathologies such as autoimmune thyroiditis (Hashimoto and Graves–Basedow), type I diabetes, and systemic lupus erythematosus. The current review aims to present a summary of the data from the specialized literature regarding the intercurrents between celiac disease and lupus by analyzing the most recent studies published on PubMed.

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Section: Epidemiologysupporting

confidence: 69%

Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat

Lupu,

Jechel,

Mihai

et al. 2023

Nutrients

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“…In some autoimmune diseases, such as SLE, there was supposed a relation with CD due to DGP positivity. The use of more specific antibodies (EMA, tTG) showed that this association is not frequent but more likely similar to general population [22]. Back pain and sacroiliitis in long-standing CD were also reported [23].…”

Section: Dear Editormentioning

confidence: 87%

Rheumatologic manifestations in celiac disease: what should we remember?

Dima

Jurcuţ²,

Jinga

2019

Romanian Journal of Internal Medicine

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“…On the other hand, earlier studies using gliadin-based serology have shown significant positivity of CD-related antibodies in SS: Teppo et al[ 31 ] found higher values of gliadin, gluten and reticulin antibodies in SS patients compared to rheumatoid arthritis or SLE. Significant false positivity of native AGA has also been reported also in other autoimmune diseases, such as SLE[ 32 , 33 ]. A study searching for immune and autoimmune gluten-related phenomenon in SLE patients found higher prevalence for tTG IgA and DGP (3.4% and 4.7%, respectively), but similar to general population prevalence for EMA (0.8%).…”

Section: Discussionmentioning

confidence: 99%

“…A study searching for immune and autoimmune gluten-related phenomenon in SLE patients found higher prevalence for tTG IgA and DGP (3.4% and 4.7%, respectively), but similar to general population prevalence for EMA (0.8%). Moreover, the tTG-IgA were found to be correlated with leucocytes, lymphocytes as well as with the complement levels[ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Celiac disease and Sjögren’s syndrome: A case report and review of literature

Balaban¹,

Mihai²,

Dima³

et al. 2020

WJCC

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BACKGROUND Celiac disease (CD) is a systemic, chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals, with a prevalence of 1% worldwide. Sjogren's syndrome (SS) is also a systemic autoimmune disease, mainly characterized by ocular and oral sicca symptoms and signs. Sharing a common genetic background, CD and SS are known associated autoimmune diseases, but currently available guidelines are not reporting it. CASE SUMMARY We report the case of a 39-year-old woman, who was in the care of her rheumatologist for 2 years with SS. On routine follow-up she was found to have iron deficiency, without anemia. She had no gastrointestinal complaints and denied any obvious source of blood loss. IgA tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy. A diagnosis of CD was set and gluten-free diet was recommended. CONCLUSION We present a review of existing data in the literature regarding the association of the two diseases, summarizing prevalence studies of CD in SS patients and the other way around. Screening recommendations and future research perspectives are also discussed, highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

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Immune and autoimmune gluten-related phenomenon in systemic lupus erythematosus

Cited by 5 publications

References 9 publications

Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat

Connection between Celiac Disease and Systemic Lupus Erythematosus in Children—A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat

Rheumatologic manifestations in celiac disease: what should we remember?

Celiac disease and Sjögren’s syndrome: A case report and review of literature

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