Immune Attack against Breast Cancer Revealed in Patient Tumor Sections by Memristive Nanowire Sensors

Abstract

A foundational principle of tumor immunology is that cancer cells can be eliminated by host cytotoxic T lymphocytes. This T lymphocyte immune attack can be potentiated by novel treatment modalities called immunotherapies and, patient tumors with pre-existing immune attack are more responsive to immunotherapies. However, cancers often hijack immune attack and precision oncology seeks for decision-making tools that are able to identify immune attack in minute amounts of patient tumor biopsies. Silicon nanowire memristive sensors for biodetection are the latest generation of nanowire sensors. They have marked a new era with unprecedented detection of attomolar to femtomolar concentrations of biomolecules. Here, we have designed memristive nanowire sensors for the first ever detection of immune attack in a five micrometers section of breast cancer patient tumor biopsy. In the momentum of breast cancer immunotherapy, these sensors emerge as a technological breakthrough that has the potential to guide precision medicine in oncology.

Multisite Dopamine Sensing With Femtomolar Resolution Using a CMOS Enabled Aptasensor Chip

“…The demonstrated sensitivity in many cases has achieved the femtomolar (Puppo et al, 2013(Puppo et al, , 2014Shalev et al, 2013;Ibarlucea et al, 2018) or even attomolar levels (Patolsky et al, 2006b;Buitrago et al, 2014;Tzouvadaki et al, 2016), with an ultimate resolution of single-analyte binding events (Patolsky et al, 2004). The published works have shown that detection in hostile environments such as breast cancer tissue (Tuoheti et al, 2020), blood plasma (Nguyen-Le et al, 2022, or saliva (Klinghammer et al, 2020) is possible. The latter aimed at cortisol hormones as target, showing that such platforms hold great promise for monitoring DA in other body fluids.…”