Immune biomarkers for chronic inflammation related complications in non-cancerous and cancerous diseases

Meirow, Yaron; Baniyash, Michal

doi:10.1007/s00262-017-2035-6

Cited by 43 publications

(30 citation statements)

References 75 publications

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“…The immunomodulatory and anti-inflammatory effects of H. aurantium tunic fatty acids on RAW264.7 cells, were evaluated by the production of PGE 2 , one of the critical immune biomarkers [ 21 ]. Figure 5 A shows that the production of PGE 2 was dose-dependently increased according to the concentration of H. aurantium tunic fatty acids.…”

Section: Resultsmentioning

confidence: 99%

Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells

Monmai

Shin

et al. 2018

Marine Drugs

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Halocynthia aurantium, an edible ascidian species, has not been studied scientifically, even though tunicates and ascidians are well-known to contain several unique and biologically active materials. The current study investigated the fatty acid profiles of the H. aurantium tunic and its immune-regulatory effects on RAW264.7 macrophage cells. Results of the fatty acid profile analysis showed a difference in ratios, depending on the fatty acids being analysed, including those of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA). In particular, omega-3 fatty acids, such as eicosatrienoic acid n-3 (ETA n-3), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), were much higher than omega-6 fatty acids. Moreover, the H. aurantium tunic fatty acids, significantly and dose-dependently, increased the NO and prostaglandin E2 (PGE2) production in RAW264.7 cells, for immune-enhancement without cytotoxicity. In addition, these fatty acids regulated the transcription of immune-associated genes, including iNOS, IL-1β, IL-6, COX-2, and TNF-α. These actions were activated and deactivated via Mitogen-activated protein kinase (MAPK)and NF-κB signaling, to regulate the immune responses. Conversely, the H. aurantium tunic fatty acids effectively suppressed the inflammatory cytokine expressions, including iNOS, IL-1β, IL-6, COX-2, and TNF-α, in LPS-stimulated RAW264.7 cells. Productions of COX-2 and PGE2, which are key biomarkers for inflammation, were also significantly reduced. These results elucidated the immune-enhancement and anti-inflammatory mechanisms of the H. aurantium tunic fatty acids in macrophage cells. Moreover, the H. aurantium tunic might be a potential fatty acid source for immune-modulation.

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Section: Resultsmentioning

confidence: 99%

Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells

Monmai

Shin

et al. 2018

Marine Drugs

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“…Importantly, many therapeutic treatments employed up to date have failed to produce a desirable effect, since a permissive immune environment is a prerequisite for their proper function. Nowadays, there is no doubt that chronic inflammation and associated immunosuppression pose a serious obstacle in the prognostic and the therapeutic area, as they both develop with no palpable clinical signs, often leading to unforeseeable complications and possible unresponsiveness to various therapies [ 42 ]. Apart from therapeutic interventions, long-term lifestyle measures such as healthy nutrition and exercise may provide preventive results or countermeasures towards inflammatory manifestations.…”

Section: Introductionmentioning

confidence: 99%

Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties

2017

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In this review paper, the latest literature on the functional properties of phospholipids in relation to inflammation and inflammation-related disorders has been critically appraised and evaluated. The paper is divided into three sections: Section 1 presents an overview of the relationship between structures and biological activities (pro-inflammatory or anti-inflammatory) of several phospholipids with respect to inflammation. Section 2 and Section 3 are dedicated to the structures, functions, compositions and anti-inflammatory properties of dietary phospholipids from animal and marine sources. Most of the dietary phospholipids of animal origin come from meat, egg and dairy products. To date, there is very limited work published on meat phospholipids, undoubtedly due to the negative perception that meat consumption is an unhealthy option because of its putative associations with several chronic diseases. These assumptions are addressed with respect to the phospholipid composition of meat products. Recent research trends indicate that dairy phospholipids possess anti-inflammatory properties, which has led to an increased interest into their molecular structures and reputed health benefits. Finally, the structural composition of phospholipids of marine origin is discussed. Extensive research has been published in relation to ω-3 polyunsaturated fatty acids (PUFAs) and inflammation, however this research has recently come under scrutiny and has proved to be unreliable and controversial in terms of the therapeutic effects of ω-3 PUFA, which are generally in the form of triglycerides and esters. Therefore, this review focuses on recent publications concerning marine phospholipids and their structural composition and related health benefits. Finally, the strong nutritional value of dietary phospholipids are highlighted with respect to marine and animal origin and avenues for future research are discussed.

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“…Inflammation is a vital protective response of the body characterised by the synthesis and release of pro-inflammatory cytokines, such as tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6), upregulation of enzymes (e.g., cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)), and stimulation of intracellular signalling pathways, particularly those activating nuclear factor kappa-B (NF-κB), a transcription factor that orchestrates inflammatory responses in many tissues [1][2][3]. A long-term, uncontrolled, low-grade inflammatory response is involved in many chronic conditions, such as obesity, diabetes, bronchitis, pancreatitis, colitis, and cardiovascular disease, as well as some types of cancer [2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells

et al. 2020

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The anti-inflammatory effects of curcumin are well documented. However, the bioavailability of curcumin is a major barrier to its biological efficacy. Low-dose combination of complimentary bioactives appears to be an attractive strategy for limiting barriers to efficacy of bioactive compounds. In this study, the anti-inflammatory potential of curcumin in combination with chlorogenic acid (CGA), was investigated using human THP-1 macrophages stimulated with lipopolysaccharide (LPS). Curcumin alone suppressed TNF-α production in a dose-dependent manner with a decrease in cell viability at higher doses. Although treatment with CGA alone had no effect on TNF-α production, it however enhanced cell viability and co-administration with curcumin at a 1:1 ratio caused a synergistic reduction in TNF-α production with no impact on cell viability. Furthermore, an qRT-PCR analysis of NF-κB pathway components and inflammatory biomarkers indicated that CGA alone was not effective in reducing the mRNA expression of any of the tested inflammatory marker genes, except TLR-4. However, co-administration of CGA with curcumin, potentiated the anti-inflammatory effects of curcumin. Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-α (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-κB (~78%), IκB-β-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level. Overall, co-administration with CGA improved the inflammation-lowering effects of curcumin in THP-1 cells.

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Immune biomarkers for chronic inflammation related complications in non-cancerous and cancerous diseases

Cited by 43 publications

References 75 publications

Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells

Immune-Enhancement and Anti-Inflammatory Activities of Fatty Acids Extracted from Halocynthia aurantium Tunic in RAW264.7 Cells

Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties

Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells

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