Immune cell death-related lncRNA signature as a predictive factor of clinical outcomes and immune checkpoints in gastric cancer

Abstract

Background: Immune cell death (ICD) is a type of tumor cell death that has recently been shown to activate and regulate tumor immunity. However, the role of ICD-related long non-coding RNAs (lncRNAs) in gastric cancer remains to be clarified.Methods: We obtained 375 tumor samples from the Cancer Genome Atlas (TCGA) database and randomly assigned them to training and verification groups. LASSO and Cox regression analysis were utilized to identify ICD-related lncRNAs and establish a risk model. The changes in the immune microenvironment of the two groups were compared by examining the tumor-infiltrating immune cells.Results: We established a tumor signature based on nine ICD-related lncRNAs. In light of the receiver operating characteristic and Kaplan–Meier curves, the prognostic values of this risk model were verified. Multivariate regression analysis showed that the risk score was an independent risk factor for the prognosis of patients in both the training cohort (HR 2.52; 95% CI: 1.65–3.87) and validation cohort (HR 2.70; 95% CI: 1.54–4.8). A nomogram was developed to predict the 1-, 3-, and 5-year survival of patients with gastric cancer, and the signature was linked to high levels of immunological checkpoint expression (B7-H3, VSIR).Conclusions: An ICD-related lncRNA signature could predict the immune response and prognosis of patients with gastric cancer. This prognostic signature could be employed to independently monitor the efficacy of immunotherapy for gastric cancer patients.

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“…For this reason, a bioinformatics analysis was carried out in this research in order to identify novel biomarkers that could contribute to early diagnosis. Tsvetkov et al recently revealed a brand-new mechanism of cell death (cuprotosis), which is completely different from the existing cell death mechanism, as well as has great application potential in tumor therapy [7,24,25]. LncRNAs were particularly attractive candidates, given their well-established role in cellular differentiation, growth and development, and their documented association with aberrant expression patterns in various diseases, including malignancies [26].…”

Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients

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Editorial: The roles of ion-induced cell death in cancer treatment: volume II

“…Long non-coding RNAs (lncRNAs) are a class of RNA molecules that, while not coding for proteins, have been increasingly recognized for their pivotal roles in regulating gene expression, cellular processes, and pathways ( Zhang et al, 2023 ). Aberrant expression of lncRNAs has been implicated in cancer initiation, progression, and metastasis, marking them as potential diagnostic markers and therapeutic targets ( Peng et al, 2023 ).…”