2024
DOI: 10.1038/s41598-024-67213-4
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Immune cell landscapes are associated with high-grade serous ovarian cancer survival

Guoan Zhang,
Yan Zhang,
Jingjing Zhang
et al.

Abstract: High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy resistance in HGSOC. Transcriptome deconvolution was performed to address cellular heterogeneity. Kaplan–Meier survival curves were plotted to illustrate the outcomes of patients with varying cellular abundances. The association between gene expression and chemotherapy response was tested.… Show more

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