Immune cell-mediated liver injury

Corazza, Nadia; Badmann, Anastasia; Lauer, Christoph

doi:10.1007/s00281-009-0168-1

Cited by 23 publications

(17 citation statements)

References 97 publications

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“…However, studies with an increased number of patients should be completed to evaluate this hypothesis. In addition, findings demonstrating that a strong and sustained CD4 + T cell-specific Th1 response during hepatotropic virus infections can result in clearance of viral infection (Corazza et al 2009) are consistent with our observation of IFN-γ over expression patients who resolved HBV infection (Fig. 4C).…”

Section: Discussionsupporting

confidence: 79%

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Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Fierro¹,

Román²,

Realpe³

et al. 2011

Mem. Inst. Oswaldo Cruz

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A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected patients has been poorly evaluated in vivo. Therefore, we assessed the expression profiles of 23 cytokines in OHB genotype H-infected Nahua patients. A total of 41 sera samples from natives of the Nahua community were retrospectively analysed. Based on their HBV antibody profiles, patients were stratified into two groups: OHB patients (n = 21) and patients that had recovered from HBV infection (n = 20). Herein, we report distinctive cytokines profiles in OHB-infected individuals. Compared to healthy controls (n = 20) and patients who resolved HBV infection, OHB-infected patients displayed an increase in interleukin (IL)-2 secretion in addition to a characteristic inflammation profile (decrease in IL-8 and tumour necrosis factor-alpha levels and increased levels of tumour growth factor-beta). IL-15 and interferon-gamma levels were reduced in OHB-infected individuals when compared to those patients who resolved HBV infection. In contrast, OHB patients showed an increase in monocyte chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls and patients who resolved HBV infection. These findings suggest that cytokine expression can influence the severity of OHB disease and could lead to new investigation into the treatment of liver and other infectious diseases

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Section: Discussionsupporting

confidence: 79%

“…Additionally, it is accepted that liver damage is likely a result of the immune response to HBV infection (Racanelli & Rehermann 2006, Corazza et al 2009, Wang & Zhang 2009 OHB-infected Nahua natives to determine if cytokine expression levels distinguish OHB, genotype H-infected patients as a result of a coordinated immune response.…”

mentioning

confidence: 99%

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Fierro¹,

Román²,

Realpe³

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Activation of the pro-inflammatory cytokine cascade such as TNFα is considered to play an important role in the pathophysiology and clinical outcome of severe liver injury [24], which has been confirmed with TNFα knockout or TNFα receptor p55 knockout mice [25,16]. This model was also studied for potential protection by sTNFRII-Fc and the two DNTNF biologics XENP1595 and XENP345 [26,27]. Most recently, TNFα-induced apoptosis was reported to be associated with Fas and FasL up-regulation.…”

Section: Discussionmentioning

confidence: 91%

Protective effects of a novel trimerized sTNFRII on acute liver injury

Luo¹,

Liu²,

Zhang³

et al. 2012

International Immunopharmacology

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“…Amounts of serum-soluble TNFR1 and TNFR2 were also found to be higher 8 h after BCG/LPS (sTNFR1: 5.5-fold, sTNFR2: 2-fold) than after D-GALN/LPS. These data reflect a different regulation and cell origin of solTNF and sTNFRs, which can be produced and released by many immune cells in the BCG/LPS mouse model, whereas in D-GALN/LPS-induced hepatitis, solTNF is predominantly secreted by Kupffer cells [37].…”

Section: Serum Levels Of Soltnf and Soluble Tnfr1 And Tnfr2 In Bcg/lpmentioning

confidence: 98%