Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration

Zhao, Xueying; Deng, Hui; Feng, Yuan; Wang, Yuehan; Yao, Xiaomin; Ma, Yuyang; Zhang, Luzhong; Jie, Jing; Yang, Pengxiang; Yang, Yumin

doi:10.1039/d3tb02557h

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02557h

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Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration

Xueying Zhao,

Hui Deng,

Yuan Feng

et al.

Abstract: During the process of peripheral nerve repair there involve many complexes pathological and physiological changes including multi-cellular responses and various signaling molecules, all those events establish a dynamic microenvironment for...

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Cited by 3 publications

References 172 publications

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Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Li,

Wu,

Cheng

et al. 2024

Small

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Critical‐sized bone defects represent an urgent clinical problem, necessitating innovative treatment approaches. Gene‐activated grafts for bone tissue engineering have emerged as a promising solution. However, traditional gene delivery methods are constrained by limited osteogenic efficacy and safety concerns. Recently, organic and inorganic nanoparticle (NP) vectors have attracted significant attention in bone tissue engineering for their safe, stable, and controllable gene delivery. Targeted gene delivery guided by insights into bone healing mechanisms, coupled with the multifunctional design of NPs, is crucial for enhancing therapeutic outcomes. Here, the theoretical foundations underlying NP‐mediated gene therapy for enhancing bone healing across different histological stages are elucidated. Furthermore, the distinct attributes of functionalized NP vectors are discussed, and cutting‐edge strategies aimed at optimizing gene delivery efficiency throughout the therapeutic process are highlighted. Additionally, the review addresses the unresolved challenges and prospects of this technology. This review may contribute to the continued development and clinical application of NP‐mediated gene delivery for treating critical‐sized bone defects.

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Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Li,

Wu,

Cheng

et al. 2024

Small

View full text Add to dashboard Cite

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Reprogramming metabolic microenvironment for nerve regeneration via waterborne polylactic acid-polyurethane copolymer scaffolds

Feng,

Chen,

Wang

et al. 2025

Biomaterials

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Molecular characterization of PANoptosis-related genes as novel signatures for peripheral nerve injury based on time-series transcriptome sequencing

Dai,

Shao,

et al. 2025

Gene

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Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration

Abstract: During the process of peripheral nerve repair there involve many complexes pathological and physiological changes including multi-cellular responses and various signaling molecules, all those events establish a dynamic microenvironment for...

Cited by 3 publications

References 172 publications

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Reprogramming metabolic microenvironment for nerve regeneration via waterborne polylactic acid-polyurethane copolymer scaffolds

Molecular characterization of PANoptosis-related genes as novel signatures for peripheral nerve injury based on time-series transcriptome sequencing

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