Immune Cell Metabolism in Tumor Microenvironment

Li, Yongsheng; Wan, Yisong Y.; Zhu, Bo

doi:10.1007/978-94-024-1170-6_5

Cited by 28 publications

(22 citation statements)

References 256 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differentiation and activation of pro-tumor immune cells, including myeloid-derived suppressor cells (MDSCs), M2 macrophages, regulatory T cells, and suppressing antitumor immune cells (CD8+ T cells, M1 macrophages, and N1 neutrophils) are promoted by the deprivation of nutrients [42]. Tumor-associated immune cells regulate their metabolism for survival, differentiation, and pro/antitumor functions by modulating several signaling pathways, such as PI3K-Akt, mTOR, HIF-1, and c-Myc [42]. Glycolytic metabolism activated by inflammation may be upregulated during the tumor-initiation process by HIF-1 activation in both cancer and immune cells.…”

Section: Metabolic Relationship Between Cancer Cells and Tumor-associmentioning

confidence: 99%

“…Glycolytic metabolism activated by inflammation may be upregulated during the tumor-initiation process by HIF-1 activation in both cancer and immune cells. Particularly, during tumor progression, HIF-1 up-regulation in tumor-associated macrophages (TAMs), tumor-associated dendritic cells (TADCs), MDSCs, and Tregs contributes to immune suppression and angiogenesis by PD-L1 expression, adenosine-adenosine receptor interaction, and lactate release that facilitate tumor growth [42].…”

Section: Metabolic Relationship Between Cancer Cells and Tumor-associmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

Lucchetti

Tenore

Colella

et al. 2020

Cancers

View full text Add to dashboard Cite

A better understanding of the mechanisms of cell communication between cancer cells and the tumor microenvironment is crucial to develop personalized therapies. It has been known for a while that cancer cells are metabolically distinct from other non-transformed cells. This metabolic phenotype is not peculiar to cancer cells but reflects the characteristics of the tumor microenvironment. Recently, it has been shown that extracellular vesicles are involved in the metabolic switch occurring in cancer and tumor-stroma cells. Moreover, in an immune system, the metabolic programs of different cell subsets are distinctly associated with their immunological function, and extracellular vesicles could be a key factor in the shift of cell fate modulating cancer immunity. Indeed, during tumor progression, tumor-associated immune cells and fibroblasts acquire a tumor-supportive and anti-inflammatory phenotype due to their interaction with tumor cells and several findings suggest a role of extracellular vesicles in this phenomenon. This review aims to collect all the available evidence so far obtained on the role of extracellular vesicles in the modulation of cell metabolism and immunity. Moreover, we discuss the possibility for extracellular vesicles of being involved in drug resistance mechanisms, cancer progression and metastasis by inducing immune-metabolic effects on surrounding cells.

show abstract

Section: Metabolic Relationship Between Cancer Cells and Tumor-associmentioning

confidence: 99%

Section: Metabolic Relationship Between Cancer Cells and Tumor-associmentioning

confidence: 99%

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

Lucchetti

Tenore

Colella

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…While some investigators have reported that mitochondrial ROS (mROS) stimulate macrophage expression of pro-inflammatory cytokines, other researchers have instead observed the induction of an anti-inflammatory phenotype; hence, further study is required to fully understand these events [99][100][101][102]. The glycolytic reprogramming of TAM is regulated by oxygen sensors including prolyl-hydroxylases (PHDs) and is accompanied by proton pumping and acidification of M2 macrophages that subsequently impair antitumor responses [103]. Similarly, while resting NK cells typically utilize OXPHOS, exposure to high doses of tissue damage-associated cytokine IL-15 stimulates conversion to glycolytic activity [104].…”

Section: Hypoxia Modifies the Resting Metabolic Status Of Immune Cellsmentioning

confidence: 99%

Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers

Chaudhary

Bag

Arora

et al. 2020

Front. Oral. Health

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) includes tumors of the lips, tongue, gingivobuccal complex, and floor of the mouth. Prognosis for OSCC is highly heterogeneous, with overall 5-year survival of ~50%, but median survival of just 8–10 months for patients with locoregional recurrence or metastatic disease. A key feature of OSCC is microenvironmental oxygen depletion due to rapid growth of constituent tumor cells, which triggers hypoxia-associated signaling events and metabolic adaptations that influence subsequent tumor progression. Better understanding of leukocyte responses to tissue hypoxia and onco-metabolite expression under low-oxygen conditions will therefore be essential to develop more effective methods of diagnosing and treating patients with OSCC. This review assesses recent literature on metabolic reprogramming, redox homeostasis, and associated signaling pathways that mediate crosstalk of OSCC with immune cells in the hypoxic tumor microenvironment. The likely functional consequences of this metabolic interface between oxygen-starved OSCC and infiltrating leukocytes are also discussed. The hypoxic microenvironment of OSCC modifies redox signaling and alters the metabolic profile of tumor-infiltrating immune cells. Improved understanding of heterotypic interactions between host leukocytes, tumor cells, and hypoxia-induced onco-metabolites will inform the development of novel theranostic strategies for OSCC.

show abstract

“…On the other hand, TME can reprogram the metabolism of an immune cell ( 16 ), reducing immune activation signals, downregulating antigen recognition and presentation, and making tumor cells escape from host immune surveillance ( 17 ), thus causing tumor immune escape. Early invasion of immune cells, such as macrophages, lymphocytes, natural killer (NK) cells, and DCs, is essential for anti-tumor immunity.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

Peng

Huang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Dendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on capturing antigens coming from pathogens or tumors and presenting to T cells for immune response. The metabolism of DCs controls its development, polarization, and maturation processes and provides energy support for its functions. However, the immune activity of DCs in tumor microenvironment (TME) is inhibited generally. Abnormal metabolism of tumor cells causes metabolic changes in TME, such as hyperglycolysis, lactate and lipid accumulation, acidification, tryptophan deprivation, which limit the function of DCs and lead to the occurrence of tumor immune escape. Combined metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in oncology therapy. Therefore, we reviewed the glucose, lipid, and amino acid metabolism of DCs, as well as the metabolic changes after being affected by TME. Together with the potential metabolic targets of DCs, possible anti-tumor therapeutic pathways were summarized.

show abstract

Immune Cell Metabolism in Tumor Microenvironment

Cited by 28 publications

References 256 publications

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

Contact Info

Product

Resources

About