2024
DOI: 10.1136/jitc-2024-009550
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Immune cell topography of head and neck cancer

Tara Muijlwijk,
Dennis N L M Nijenhuis,
Sonja H Ganzevles
et al.

Abstract: BackgroundApproximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. Immune checkpoint inhibitors are treatment options for recurrent/metastatic HNSCC; however, less than 20% of patients respond. To increase this response rate, it is fundamental to increase our understanding of the spatial tumor immune microenvironment (TIME).MethodsIn total, 53 HNSCC specimens were included. Using a seven-color multiplex immunohistochemistry panel we identified tumor cells,… Show more

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