Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

Hazrati, A.; Soudi, Sara; Malekpour, Kosar; Mahmoudi, Mohammad; Rahimi, Asgar Bradaran; Hashemi, Seyed Mahmoud; Varma, Rajender S.

doi:10.1186/s40364-022-00374-4

Cited by 75 publications

(49 citation statements)

References 206 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of mitochondrial, centrosomal, and ribosomal proteins on MVs suggests their roles in protein translation. In addition, microglial exosomes are involved in antigen presentation, such as the transfer of antigens, indicating a functional role in immune response and are essential for regulating the brain-immune system interaction ( Kalluri and LeBleu, 2020 ; Guo et al, 2021 ; Hazrati et al, 2022 ). Studies have revealed that neurodegenerative disease-related proteins are transported by microglial exosomes.…”

Section: Microglia and Its Interaction With Brain Cellsmentioning

confidence: 99%

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

Maurya

Gupta

Mishra

2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

The emerging role of microglia in brain homeostasis, neurodegeneration, and neurodevelopmental disorders has attracted considerable interest. In addition, recent developments in microglial functions and associated pathways have shed new light on their fundamental role in the immunological surveillance of the brain. Understanding the interconnections between microglia, neurons, and non-neuronal cells have opened up additional avenues for research in this evolving field. Furthermore, the study of microglia at the transcriptional and epigenetic levels has enhanced our knowledge of these native brain immune cells. Moreover, exploring various facets of microglia biology will facilitate the early detection, treatment, and management of neurological disorders. Consequently, the present review aimed to provide comprehensive insight on microglia biology and its influence on brain development, homeostasis, management of disease, and highlights microglia as potential therapeutic targets in neurodegenerative and neurodevelopmental diseases.

show abstract

Section: Microglia and Its Interaction With Brain Cellsmentioning

confidence: 99%

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

Maurya

Gupta

Mishra

2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…In this study, it is shown that PBMCs that were infected and uninfected with H. pylori secrete exosomes, however, the methods that were used make it impossible to demonstrate whether there are differences in the number of exosomes that are secreted. PBMCs including NK cells, dendritic cells, macrophages, mast cells, B lymphocytes, and T lymphocytes can secrete exosomes [ 50 , 51 , 52 , 53 , 54 ]. Previous studies show that exosomes are related to the development of gastrointestinal diseases such as chronic gastritis and gastric cancer, and also to the progression to extra-gastrointestinal diseases, including atherosclerosis [ 17 , 18 , 19 , 20 , 21 , 49 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

In Peripheral Blood Mononuclear Cells Helicobacter pylori Induces the Secretion of Soluble and Exosomal Cytokines Related to Carcinogenesis

Atrisco-Morales

Ramı́rez

Castañón-Sánchez³

et al. 2022

IJMS

View full text Add to dashboard Cite

Helicobacter pylori promotes the secretion of cytokines that regulate inflammation and carcinogenesis. Immune cells secrete cytokines into the extracellular medium or packaged in exosomes. The objective of this study was to analyze the profile of soluble and exosomal cytokines that were secreted by human peripheral blood mononuclear cells (PBMCs) that were infected with H. pylori and to build a network of interaction between cytokines and cellular proteins. PBMCs were obtained by density gradient centrifugation and infected with H. pylori for 24 h. The infection was verified by immunofluorescence and Western blot for CagA. The exosomes were obtained from culture supernatant by ultracentrifugation and characterized by transmission electron microscopy, particle size analysis, and Western blot for CD9 and CD81. Cytokines were quantified using a multiplex immunoassay in the culture supernatant, intact exosomes, and lysed exosomes. H. pylori adheres to lymphocytes and translocates CagA. In PBMCs, H. pylori induces an increase in the soluble and exosomal IL-1β, IL-6, TNF-α, IL-10, IL-17A, IL-21, and IL-22. The protein–protein interaction (PPI) network shows that soluble and exosomal cytokines interact with proteins that participate in signaling pathways such as NF-κB, MAPK, PI3K-Akt, Jak-STAT, FoxO, and mTOR, that are related to carcinogenesis; moreover, TNF-α had the highest number of interactions. Cytokine-loaded exosomes represent another means of intercellular communication that is activated by H. pylori to stimulate inflammation, carcinogenesis, or cancer progression. Cytokine-loaded exosomes are likely to be associated with extragastrointestinal diseases of inflammatory origin.

show abstract

“…responses (20). Therefore, a large number of researches have used immune cells-derived Exos as drug carriers for cancer immunotherapy.…”

Section: Immune Cells-derived Exosmentioning

confidence: 99%

Exosomes as smart drug delivery vehicles for cancer immunotherapy

et al. 2023

View full text Add to dashboard Cite

Exosomes (Exos) as drug delivery vehicles have been widely used for cancer immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity. Some Exos-based cancer immunotherapy strategies such as tuning of immunosuppressive tumor microenvironment, immune checkpoint blockades, and cancer vaccines have also been investigated in recent years, which all showed excellent therapeutic effects for malignant tumor. Furthermore, some Exos-based drug delivery systems (DDSs) for cancer immunotherapy have also undergone clinic trails, indicating that Exos are a promising drug delivery carrier. In this review, in order to promote the development of Exos-based DDSs in cancer immunotherapy, the biogenesis and composition of Exos, and Exos as drug delivery vehicles for cancer immunotherapy are summarized. Meanwhile, their clinical translation and challenges are also discussed. We hope this review will provide a good guidance for Exos as drug delivery vehicles for cancer immunotherapy.

show abstract

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

Cited by 75 publications

References 206 publications

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

In Peripheral Blood Mononuclear Cells Helicobacter pylori Induces the Secretion of Soluble and Exosomal Cytokines Related to Carcinogenesis

Exosomes as smart drug delivery vehicles for cancer immunotherapy

Contact Info

Product

Resources

About