Immune complex formation in mice after ultraviolet radiation

Photosensitivity in cutaneous lupus erythematosus: lessons from mice and men

“…In NZB mice, the relationships between autoimmunity, chromosomal abnormalities and clastogenic factors were examined [15], and the UV sensitivity of NZB cell lines was also reported [16]. B/W F1 mice, which have manifestations more similar to human SLE than NZB mice, produced high serum titers of ANA and anti-DNA antibodies following whole body irradiation with UVC light [17]. Broad-spectrum UV-irradiation increases mortality in BXSB male mice, and accelerates autoimmune traits including anti-DNA antibody production, splenic polyclonal B cell activity and glomerulonephritis [18].…”