Immune Complexes in Cystic Fibrosis

Active Immunization with Lipopolysaccharide Pseudomonas Antigen for Chronic Pseudomonas Bronchopneumonia in Guinea Pigs

“…Thus, further elevations in humoral antibody, raised by active immunization, might not offer benefit. Third, circulating immune complexes are seen at increased frequency among infected CF patients (12)(13)(14)(15), and it is possible that these complexes result from the presence of Pseudomonas antigen with elevated titers of Pseudomonas antibodies. Such complexes, if deposited in lung tissues, might predispose to hypersensitivity lung disease (12,13), and further immune stimulation by vaccine would be contraindicated in that setting.…”

Circulating Immune Complexes in Cystic Fibrosis and Their Correlation to Clinical Parameters

“…It is well documented that CIC are elevated in 40 to 86% of patients with CF, depending on the investigation (1)(2)(3)(4)(5)(6). The initial intent of this investigation was to evaluate the use of CIC determinations as a clinical measure of CF exacerbation and response to antimicrobial therapy.…”

The Carbohydrate Convent of IgG from Patients with Cystic Fibrosis

“…Formation of antigen-antibody complexes uncovers the immunoglobulin oligosaccharides. Substantial amounts of circulating IgG in CF may be antigen bound (25). In this case, the terminal sugars may become susceptible to removal by circulating glycosidases.…”

“…Diminished glycosylation of the antennae may contribute to the elevated levels of IgG and of circulating antigen-antibody complexes (25) in older subjects with CF. Thornburg et a/.…”